| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 4,957,252 | 4,994,728 | +37,476 | 1.62 | 2.38 | +0.76 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,313,920 | 4,313,920 | 0 | 0.48 | 0.68 | +0.20 | hold |
| Sands Capital Alternatives, LLC | 3,570,113 | 3,570,113 | 0 | 15.54 | 20.98 | +5.44 | hold |
| MORGAN STANLEY | 3,761,583 | 3,459,453 | -302,130 | 0.00 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 2,781,331 | 2,913,920 | +132,589 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 3,870,158 | 2,534,565 | -1,335,593 | 4.11 | 3.28 | -0.83 | sell |
| RTW INVESTMENTS, LP | 3,299,191 | 2,500,000 | -799,191 | 0.81 | 0.76 | -0.04 | sell |
| VANGUARD GROUP INC | 2,216,185 | 2,218,238 | +2,053 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 1,327,100 | +1,327,100 | 0.00 | 0.07 | +0.07 | buy |
| Omega Fund Management, LLC | 1,920,125 | 1,316,183 | -603,942 | 17.16 | 14.00 | -3.16 | sell |
| Point72 Asset Management, L.P. | 0 | 987,351 | +987,351 | 0.00 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,058,975 | 956,784 | -102,191 | 0.15 | 0.20 | +0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 796,964 | 945,461 | +148,497 | 0.01 | 0.02 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,168,415 | 938,308 | -230,107 | 0.36 | 0.37 | +0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 917,553 | 921,464 | +3,911 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 826,302 | 863,133 | +36,831 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 678,262 | +678,262 | 0.00 | 1.16 | +1.16 | buy |
| Walleye Capital LLC | 591,187 | 646,539 | +55,352 | 0.10 | 0.11 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 277,944 | 602,944 | +325,000 | 0.16 | 0.34 | +0.18 | buy |
| Vestal Point Capital, LP | 600,000 | 600,000 | 0 | 0.54 | 0.67 | +0.13 | hold |
| 12 West Capital Management LP | 0 | 575,000 | +575,000 | 0.00 | 2.09 | +2.09 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 487,658 | 532,749 | +45,091 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 197,707 | 432,340 | +234,633 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 364,448 | 430,403 | +65,955 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,764 | 410,603 | +246,839 | 0.00 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 399,253 | 405,408 | +6,155 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 205,955 | 348,671 | +142,716 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 339,300 | +339,300 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 330,692 | 331,623 | +931 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 320,880 | +320,880 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 298,060 | 284,453 | -13,607 | 0.00 | 0.00 | +0.00 | sell |
| PURA VIDA INVESTMENTS, LLC | 281,250 | 281,250 | 0 | 34.05 | 32.03 | -2.02 | hold |
| TUDOR INVESTMENT CORP ET AL | 38,593 | 259,632 | +221,039 | 0.00 | 0.04 | +0.04 | buy |
| First Eagle Investment Management, LLC | 233,202 | 253,702 | +20,500 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 127,905 | 251,438 | +123,533 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 594,902 | 227,956 | -366,946 | 0.01 | 0.01 | -0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 222,615 | 217,796 | -4,819 | 0.68 | 1.01 | +0.33 | sell |
| Russell Investments Group, Ltd. | 94,227 | 205,837 | +111,610 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,815 | 201,892 | +194,077 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 204,292 | 197,939 | -6,353 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 23,346 | 151,647 | +128,301 | 0.00 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 150,277 | +150,277 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 34,614 | 140,592 | +105,978 | 0.00 | 0.01 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 138,138 | +138,138 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 30,200 | 137,200 | +107,000 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 85,741 | 121,246 | +35,505 | 0.07 | 0.16 | +0.09 | buy |
| Invesco Ltd. | 48,720 | 117,360 | +68,640 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 115,761 | +115,761 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 90,118 | 99,783 | +9,665 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 14,394 | 89,405 | +75,011 | 0.01 | 0.09 | +0.08 | buy |
| Jump Financial, LLC | 0 | 86,504 | +86,504 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 53,490 | 85,379 | +31,889 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,515 | 84,973 | +82,458 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 83,421 | +83,421 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 47,299 | 82,862 | +35,563 | 0.01 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 64,283 | 72,285 | +8,002 | 0.03 | 0.04 | +0.02 | buy |
| Holocene Advisors, LP | 0 | 71,777 | +71,777 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 60,076 | 65,876 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 54,414 | 60,664 | +6,250 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 55,266 | 54,541 | -725 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 51,400 | +51,400 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 52,010 | 50,405 | -1,605 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 31,954 | 50,312 | +18,358 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 48,100 | +48,100 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 48,074 | +48,074 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,404 | 46,439 | +4,035 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 43,990 | +43,990 | 0.00 | 0.04 | +0.04 | buy |
| Lisanti Capital Growth, LLC | 0 | 42,985 | +42,985 | 0.00 | 0.31 | +0.31 | buy |
| RHUMBLINE ADVISERS | 47,117 | 42,858 | -4,259 | 0.00 | 0.00 | +0.00 | sell |
| Divisadero Street Capital Management, LP | 0 | 39,606 | +39,606 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 38,004 | 39,300 | +1,296 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 38,991 | 37,374 | -1,617 | 0.00 | 0.00 | +0.00 | sell |
| Calamos Advisors LLC | 32,302 | 36,091 | +3,789 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,500 | 35,400 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 40,465 | 35,191 | -5,274 | 0.43 | 0.56 | +0.13 | sell |
| Lighthouse Investment Partners, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.04 | +0.04 | buy |
| Numerai GP LLC | 0 | 34,285 | +34,285 | 0.00 | 0.13 | +0.13 | buy |
| AMERIPRISE FINANCIAL INC | 35,490 | 32,409 | -3,081 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 26,610 | 31,883 | +5,273 | 0.00 | 0.00 | +0.00 | buy |
| Evanson Asset Management, LLC | 33,772 | 31,272 | -2,500 | 0.04 | 0.05 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 30,366 | +30,366 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 24,152 | +24,152 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,720 | 22,720 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 56,259 | 20,906 | -35,353 | 0.03 | 0.03 | -0.00 | sell |
| Mariner, LLC | 21,388 | 20,671 | -717 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 14,856 | 18,744 | +3,888 | 0.02 | 0.05 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 17,378 | +17,378 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 16,810 | 17,111 | +301 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 14,833 | +14,833 | 0.00 | 0.00 | +0.00 | buy |
| Gladstone Institutional Advisory LLC | 14,200 | 14,200 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Sigma Planning Corp | 0 | 13,500 | +13,500 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 13,142 | +13,142 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,891 | +12,891 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 10,225 | 12,861 | +2,636 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,200 | 12,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,024 | +12,024 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 11,946 | 11,946 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Man Group plc | 0 | 11,321 | +11,321 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,203 | +11,203 | 0.00 | 0.01 | +0.01 | buy |
| Baader Bank Aktiengesellschaft | 0 | 11,000 | +11,000 | 0.00 | 0.03 | +0.03 | buy |