| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 277,944 | 602,944 | +325,000 | 0.16 | 0.33 | +0.17 | buy |
| LORD, ABBETT & CO. LLC | 364,448 | 430,403 | +65,955 | 0.02 | 0.04 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 4,957,252 | 4,994,728 | +37,476 | 1.62 | 2.38 | +0.76 | buy |
| Granahan Investment Management, LLC | 85,741 | 121,246 | +35,505 | 0.07 | 0.16 | +0.09 | buy |
| First Eagle Investment Management, LLC | 233,202 | 253,702 | +20,500 | 0.01 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 64,283 | 72,285 | +8,002 | 0.03 | 0.04 | +0.02 | buy |
| Calamos Advisors LLC | 32,302 | 36,091 | +3,789 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 38,991 | 37,374 | -1,617 | 0.00 | 0.00 | +0.00 | sell |
| Evanson Asset Management, LLC | 33,772 | 31,272 | -2,500 | 0.04 | 0.05 | +0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 222,615 | 217,796 | -4,819 | 0.68 | 1.01 | +0.33 | sell |
| Values First Advisors, Inc. | 40,465 | 35,191 | -5,274 | 0.43 | 0.56 | +0.13 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 56,259 | 20,906 | -35,353 | 0.04 | 0.03 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,058,975 | 956,784 | -102,191 | 0.15 | 0.20 | +0.05 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,168,415 | 938,308 | -230,107 | 0.35 | 0.37 | +0.01 | sell |
| Omega Fund Management, LLC | 1,920,125 | 1,316,183 | -603,942 | 17.16 | 14.00 | -3.16 | sell |
| RTW INVESTMENTS, LP | 3,299,191 | 2,500,000 | -799,191 | 0.81 | 0.76 | -0.04 | sell |
| Soleus Capital Management, L.P. | 3,870,158 | 2,534,565 | -1,335,593 | 4.11 | 3.28 | -0.83 | sell |