| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,530,008 | 2,714,503 | +1,184,495 | 0.60 | 1.06 | +0.45 | buy |
| BAKER BROS. ADVISORS LP | 3,946,515 | 5,010,030 | +1,063,515 | 0.76 | 0.94 | +0.18 | buy |
| Capital Research Global Investors | 5,163,543 | 5,344,701 | +181,158 | 0.03 | 0.03 | +0.00 | buy |
| Redmile Group, LLC | 521,117 | 640,202 | +119,085 | 1.15 | 1.60 | +0.45 | buy |
| Rhenman & Partners Asset Management AB | 255,500 | 343,800 | +88,300 | 1.05 | 1.21 | +0.16 | buy |
| Atle Fund Management AB | 31,133 | 94,478 | +63,345 | 1.30 | 0.95 | -0.35 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 91,637 | 138,708 | +47,071 | 0.77 | 1.27 | +0.50 | buy |
| SummitTX Capital, L.P. | 162,733 | 204,872 | +42,139 | 0.17 | 0.20 | +0.03 | buy |
| TEMA ETFS LLC | 112,309 | 135,847 | +23,538 | 0.25 | 0.16 | -0.09 | buy |
| DAFNA Capital Management LLC | 476,740 | 497,240 | +20,500 | 3.61 | 3.53 | -0.08 | buy |
| Knights of Columbus Asset Advisors LLC | 39,530 | 47,328 | +7,798 | 0.07 | 0.09 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 15,583 | 15,243 | -340 | 0.04 | 0.03 | -0.01 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 181,593 | 173,785 | -7,808 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 1,107,708 | 1,092,301 | -15,407 | 0.19 | 0.18 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 141,048 | 87,747 | -53,301 | 0.04 | 0.02 | -0.01 | sell |
| Sofinnova Investments, Inc. | 1,131,786 | 925,119 | -206,667 | 1.43 | 1.78 | +0.35 | sell |
| Fiera Capital Corp | 2,527,076 | 1,445,885 | -1,081,191 | 0.29 | 0.20 | -0.09 | sell |