| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,566,278 | 4,052,500 | +486,222 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,551,891 | 3,808,450 | +256,559 | 0.08 | 0.09 | 0.00 | buy |
| Candriam S.C.A. | 395,019 | 630,019 | +235,000 | 0.10 | 0.18 | +0.08 | buy |
| Fisher Asset Management, LLC | 539,676 | 670,255 | +130,579 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 529,506 | 658,024 | +128,518 | 0.03 | 0.04 | 0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 346,490 | 286,505 | +59,985 | 0.01 | 0.01 | -0.00 | sell |
| Nicholas Investment Partners, LP | 110,351 | 155,820 | +45,469 | 0.46 | 0.70 | +0.24 | buy |
| TD ASSET MANAGEMENT INC | 137,690 | 181,890 | +44,200 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 84,500 | 123,900 | +39,400 | 0.02 | 0.03 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 74,575 | 52,045 | +22,530 | 0.19 | 0.17 | 0.00 | sell |
| First Turn Management, LLC | 382,382 | 397,782 | +15,400 | 1.95 | 2.61 | +0.66 | buy |
| ALGERT GLOBAL LLC | 22,489 | 36,869 | +14,380 | 0.03 | 0.06 | 0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 19,611 | 32,544 | +12,933 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 414,059 | 426,002 | +11,943 | 0.16 | 0.17 | +0.01 | buy |
| ALPS ADVISORS INC | 42,450 | 51,981 | +9,531 | 0.01 | 0.02 | +0.00 | buy |
| Rafferty Asset Management, LLC | 193,356 | 201,291 | +7,935 | 0.03 | 0.03 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,453 | 14,347 | +6,894 | 0.05 | 0.08 | +0.03 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 8,269 | 14,390 | +6,121 | 0.01 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 55,239 | 59,180 | +3,941 | 0.04 | 0.05 | +0.02 | buy |
| Legato Capital Management LLC | 12,494 | 14,801 | +2,307 | 0.06 | 0.08 | +0.02 | buy |
| PROFUND ADVISORS LLC | 31,976 | 31,922 | +54 | 0.05 | 0.06 | 0.00 | sell |
| Redmond Asset Management, LLC | 12,794 | 12,754 | -40 | 0.15 | 0.18 | +0.03 | sell |
| VIRTUS ADVISERS, LLC | 2,705 | 2,535 | -170 | 0.06 | 0.06 | -0.00 | sell |
| E Fund Management Co., Ltd. | 10,385 | 9,512 | -873 | 0.02 | 0.03 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 20,186 | 16,882 | -3,304 | 0.00 | 0.00 | -0.00 | sell |
| First Light Asset Management, LLC | 345,674 | 335,471 | -10,203 | 0.99 | 1.13 | +0.14 | sell |
| Redmile Group, LLC | 935,863 | 922,678 | -13,185 | 1.19 | 1.49 | +0.30 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 71,000 | 49,000 | -22,000 | 0.01 | 0.01 | -0.00 | sell |
| Informed Momentum Co LLC | 108,110 | 83,484 | -24,626 | 0.68 | 0.57 | -0.11 | sell |
| HighVista Strategies LLC | 126,845 | 99,292 | -27,553 | 1.64 | 1.55 | -0.08 | sell |
| Soleus Capital Management, L.P. | 564,700 | 533,515 | -31,185 | 2.23 | 2.06 | -0.17 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 251,295 | 217,070 | -34,225 | 6.38 | 6.30 | -0.08 | sell |
| Parkman Healthcare Partners LLC | 130,265 | 66,332 | -63,933 | 0.66 | 0.36 | -0.30 | sell |
| DAFNA Capital Management LLC | 516,341 | 446,341 | -70,000 | 4.40 | 4.46 | +0.06 | sell |
| Holocene Advisors, LP | 1,700,135 | 1,615,648 | -84,487 | 0.24 | 0.26 | +0.02 | sell |
| Logos Global Management LP | 1,800,000 | 1,500,000 | -300,000 | 7.12 | 6.93 | -0.19 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,925,094 | 2,467,107 | -457,987 | 0.22 | 0.20 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 912,786 | 441,930 | -470,856 | 0.39 | 0.19 | -0.20 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 662,343 | 162,554 | -499,789 | 0.96 | 0.29 | -0.67 | sell |
| BVF INC/IL | 1,729,043 | 1,162,306 | -566,737 | 1.54 | 1.40 | -0.14 | sell |
| Sofinnova Investments, Inc. | 1,458,881 | 781,596 | -677,285 | 2.90 | 1.91 | -0.99 | sell |
| Avidity Partners Management LP | 1,520,000 | 799,700 | -720,300 | 2.07 | 1.25 | -0.82 | sell |