| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 888,209 | 10,155,254 | +9,267,045 | 0.00 | 0.03 | +0.03 | buy |
| FEDERATED HERMES, INC. | 3,883,775 | 4,856,078 | +972,303 | 0.34 | 0.49 | +0.15 | buy |
| VANGUARD GROUP INC | 3,475,772 | 4,155,757 | +679,985 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,566,278 | 4,052,500 | +486,222 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,551,891 | 3,808,450 | +256,559 | 0.08 | 0.09 | +0.02 | buy |
| STATE STREET CORP | 2,991,899 | 3,163,954 | +172,055 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,630,292 | 2,630,292 | 0 | 1.73 | 2.01 | +0.28 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,925,094 | 2,467,107 | -457,987 | 0.22 | 0.20 | -0.01 | sell |
| Capital Research Global Investors | 1,976,870 | 1,976,870 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Holocene Advisors, LP | 1,700,135 | 1,615,648 | -84,487 | 0.24 | 0.26 | +0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,351,337 | 1,565,715 | +214,378 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 1,800,000 | 1,500,000 | -300,000 | 7.12 | 6.93 | -0.19 | sell |
| CITADEL ADVISORS LLC | 1,643,293 | 1,431,446 | -211,847 | 0.06 | 0.06 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,286,300 | 1,364,339 | +78,039 | 0.01 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 875,747 | 1,272,846 | +397,099 | 0.03 | 0.06 | +0.03 | buy |
| BVF INC/IL | 1,729,043 | 1,162,306 | -566,737 | 1.54 | 1.40 | -0.14 | sell |
| Fiera Capital Corp | 0 | 1,089,400 | +1,089,400 | 0.00 | 0.14 | +0.14 | buy |
| BAKER BROS. ADVISORS LP | 1,062,123 | 1,062,123 | 0 | 0.43 | 0.58 | +0.15 | hold |
| Redmile Group, LLC | 935,863 | 922,678 | -13,185 | 1.19 | 1.49 | +0.30 | sell |
| Avidity Partners Management LP | 1,520,000 | 799,700 | -720,300 | 2.07 | 1.25 | -0.82 | sell |
| Sofinnova Investments, Inc. | 1,458,881 | 781,596 | -677,285 | 2.91 | 2.02 | -0.88 | sell |
| MORGAN STANLEY | 1,233,271 | 763,618 | -469,653 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 539,676 | 670,255 | +130,579 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 529,506 | 658,024 | +128,518 | 0.03 | 0.04 | +0.01 | buy |
| NORTHERN TRUST CORP | 611,009 | 643,468 | +32,459 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 395,019 | 630,019 | +235,000 | 0.10 | 0.18 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 496,456 | 569,589 | +73,133 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 564,700 | 533,515 | -31,185 | 2.23 | 2.06 | -0.17 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 531,967 | 531,967 | 0 | 4.42 | 4.72 | +0.30 | hold |
| TWO SIGMA ADVISERS, LP | 48,000 | 491,300 | +443,300 | 0.00 | 0.05 | +0.05 | buy |
| Ensign Peak Advisors, Inc | 490,039 | 488,370 | -1,669 | 0.03 | 0.04 | +0.00 | sell |
| SAMLYN CAPITAL, LLC | 0 | 481,225 | +481,225 | 0.00 | 0.37 | +0.37 | buy |
| TWO SIGMA INVESTMENTS, LP | 70,469 | 479,921 | +409,452 | 0.01 | 0.05 | +0.05 | buy |
| Cormorant Asset Management, LP | 450,000 | 450,000 | 0 | 0.77 | 0.87 | +0.10 | hold |
| DAFNA Capital Management LLC | 516,341 | 446,341 | -70,000 | 4.40 | 4.46 | +0.06 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 912,786 | 441,930 | -470,856 | 0.39 | 0.19 | -0.20 | sell |
| Woodline Partners LP | 414,059 | 426,002 | +11,943 | 0.16 | 0.17 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 278,166 | 418,899 | +140,733 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 382,382 | 397,782 | +15,400 | 1.95 | 2.61 | +0.66 | buy |
| BANK OF AMERICA CORP /DE/ | 189,195 | 363,714 | +174,519 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 345,674 | 335,471 | -10,203 | 0.99 | 1.13 | +0.14 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 335,000 | 335,000 | 0 | 0.19 | 0.23 | +0.04 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 40,657 | 323,417 | +282,760 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 94,368 | 304,912 | +210,544 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 217,728 | 298,693 | +80,965 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 346,490 | 286,505 | -59,985 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 256,249 | +256,249 | 0.00 | 0.01 | +0.01 | buy |
| AXA S.A. | 243,280 | 243,348 | +68 | 0.03 | 0.03 | +0.00 | buy |
| UBS Group AG | 150,702 | 243,049 | +92,347 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 274,101 | 231,518 | -42,583 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 216,667 | 221,363 | +4,696 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 251,295 | 217,070 | -34,225 | 6.38 | 6.30 | -0.08 | sell |
| AMERIPRISE FINANCIAL INC | 224,141 | 213,514 | -10,627 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 89,698 | 205,116 | +115,418 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 193,356 | 201,291 | +7,935 | 0.03 | 0.03 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 219,957 | 181,919 | -38,038 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 137,690 | 181,890 | +44,200 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 83,984 | 173,389 | +89,405 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 662,343 | 162,554 | -499,789 | 0.96 | 0.29 | -0.67 | sell |
| Nicholas Investment Partners, LP | 110,351 | 155,820 | +45,469 | 0.46 | 0.70 | +0.24 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 138,211 | +138,211 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 17,221 | 125,252 | +108,031 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 84,500 | 123,900 | +39,400 | 0.03 | 0.05 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 207,735 | 123,015 | -84,720 | 0.01 | 0.01 | -0.01 | sell |
| Walleye Capital LLC | 199,891 | 114,037 | -85,854 | 0.10 | 0.05 | -0.05 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 92,438 | 111,921 | +19,483 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 85,100 | 111,400 | +26,300 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 110,351 | +110,351 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 126,845 | 99,292 | -27,553 | 1.64 | 1.55 | -0.08 | sell |
| TWINBEECH CAPITAL LP | 0 | 97,422 | +97,422 | 0.00 | 0.09 | +0.09 | buy |
| RHUMBLINE ADVISERS | 85,966 | 96,410 | +10,444 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 116,498 | 92,970 | -23,528 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 87,393 | +87,393 | 0.00 | 1.02 | +1.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 83,946 | +83,946 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 83,755 | +83,755 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 108,110 | 83,484 | -24,626 | 0.68 | 0.57 | -0.11 | sell |
| FIRST TRUST ADVISORS LP | 120,614 | 80,510 | -40,104 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 176,440 | 69,966 | -106,474 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 68,756 | +68,756 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 66,744 | +66,744 | 0.00 | 1.18 | +1.18 | buy |
| ALLIANCEBERNSTEIN L.P. | 57,680 | 66,500 | +8,820 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 130,265 | 66,332 | -63,933 | 0.66 | 0.36 | -0.30 | sell |
| Qube Research & Technologies Ltd | 77,516 | 60,515 | -17,001 | 0.01 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 0 | 60,375 | +60,375 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 49,452 | 59,773 | +10,321 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 59,486 | +59,486 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 55,239 | 59,180 | +3,941 | 0.03 | 0.05 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,359 | 57,535 | +9,176 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 52,976 | 55,869 | +2,893 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 18,392 | 53,724 | +35,332 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 61,226 | 52,569 | -8,657 | 0.20 | 0.20 | +0.00 | sell |
| Artia Global Partners LP | 0 | 52,492 | +52,492 | 0.00 | 0.56 | +0.56 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 74,575 | 52,045 | -22,530 | 0.08 | 0.07 | -0.02 | sell |
| ALPS ADVISORS INC | 42,450 | 51,981 | +9,531 | 0.01 | 0.02 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 71,000 | 49,000 | -22,000 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 24,578 | 44,246 | +19,668 | 0.00 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 42,943 | +42,943 | 0.00 | 0.07 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,702 | 37,609 | +6,907 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 22,489 | 36,869 | +14,380 | 0.03 | 0.06 | +0.03 | buy |