| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 1,069,090 | 2,622,192 | +1,553,102 | 2.00 | 2.81 | +0.80 | buy |
| JANUS HENDERSON GROUP PLC | 5,857,639 | 6,401,781 | +544,142 | 0.08 | 0.06 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,736,000 | 3,267,551 | +531,551 | 1.33 | 1.06 | -0.27 | buy |
| Logos Global Management LP | 3,000,000 | 3,500,000 | +500,000 | 9.02 | 10.19 | +1.17 | buy |
| Qube Research & Technologies Ltd | 759,883 | 989,335 | +229,452 | 0.03 | 0.03 | 0.00 | buy |
| Capital Research Global Investors | 2,565,897 | 2,734,923 | +169,026 | 0.01 | 0.01 | -0.00 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 120,261 | 260,261 | +140,000 | 0.22 | 0.32 | +0.10 | buy |
| Aberdeen Group plc | 306,723 | 441,305 | +134,582 | 0.01 | 0.01 | -0.00 | buy |
| DAFNA Capital Management LLC | 498,827 | 589,330 | +90,503 | 3.26 | 2.74 | -0.52 | buy |
| Fisher Asset Management, LLC | 876,599 | 965,031 | +88,432 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 423,774 | 468,578 | +44,804 | 0.03 | 0.02 | 0.00 | buy |
| NEOS Investment Management LLC | 16,066 | 56,204 | +40,138 | 0.01 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 16,066 | 56,204 | +40,138 | 0.17 | 0.28 | +0.10 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 229,316 | 262,606 | +33,290 | 0.01 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 1,184,467 | 1,209,865 | +25,398 | 0.10 | 0.07 | -0.02 | buy |
| AlphaQuest LLC | 7,661 | 27,431 | +19,770 | 0.03 | 0.05 | 0.00 | buy |
| MPM BioImpact LLC | 414,035 | 430,161 | +16,126 | 1.51 | 1.21 | -0.30 | buy |
| Nebula Research & Development LLC | 75,417 | 89,558 | +14,141 | 0.23 | 0.14 | -0.09 | buy |
| Palumbo Wealth Management LLC | 13,509 | 22,402 | +8,893 | 0.13 | 0.12 | -0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 72,716 | 69,474 | +3,242 | 0.15 | 0.09 | 0.00 | sell |
| Rafferty Asset Management, LLC | 118,227 | 121,388 | +3,161 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 8,364 | 11,344 | +2,980 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 241,894 | 244,081 | +2,187 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 23,601 | 25,632 | +2,031 | 0.02 | 0.02 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,815 | 2,213 | +398 | 0.00 | 0.00 | -0.00 | buy |
| Fountainhead AM, LLC | 64,556 | 64,901 | +345 | 0.30 | 0.17 | -0.13 | buy |
| MEEDER ASSET MANAGEMENT INC | 179 | 175 | -4 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,327 | 17,558 | -769 | 0.04 | 0.03 | -0.02 | sell |
| SAMLYN CAPITAL, LLC | 792,399 | 791,266 | -1,133 | 0.31 | 0.19 | -0.12 | sell |
| ALPS ADVISORS INC | 69,892 | 61,538 | -8,354 | 0.01 | 0.01 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,200,094 | 1,188,094 | -12,000 | 0.05 | 0.04 | -0.02 | sell |
| BIT Capital GmbH | 63,672 | 42,715 | -20,957 | 0.13 | 0.06 | -0.07 | sell |
| Rhenman & Partners Asset Management AB | 82,000 | 39,500 | -42,500 | 0.22 | 0.07 | -0.14 | sell |
| Redmile Group, LLC | 619,300 | 534,600 | -84,700 | 1.11 | 0.83 | -0.28 | sell |
| Candriam S.C.A. | 1,071,825 | 938,177 | -133,648 | 0.16 | 0.10 | -0.06 | sell |
| Woodline Partners LP | 590,697 | 315,372 | -275,325 | 0.10 | 0.03 | -0.07 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,866,908 | 3,475,622 | -391,286 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 974,636 | 526,688 | -447,948 | 0.02 | 0.01 | -0.01 | sell |
| Avidity Partners Management LP | 1,126,700 | 445,000 | -681,700 | 2.89 | 1.50 | -1.38 | sell |