| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 1,069,090 | 2,622,192 | +1,553,102 | 2.01 | 3.24 | +1.23 | buy |
| BlackRock, Inc. | 8,377,056 | 9,156,517 | +779,461 | 0.00 | 0.00 | -0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 700,000 | +700,000 | 0.00 | 5.59 | +5.59 | buy |
| JANUS HENDERSON GROUP PLC | 5,857,639 | 6,401,781 | +544,142 | 0.08 | 0.06 | -0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,736,000 | 3,267,551 | +531,551 | 1.34 | 1.06 | -0.28 | buy |
| Logos Global Management LP | 3,000,000 | 3,500,000 | +500,000 | 9.02 | 10.19 | +1.17 | buy |
| BANK OF AMERICA CORP /DE/ | 747,934 | 1,185,186 | +437,252 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 123,012 | 547,637 | +424,625 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 306,708 | +306,708 | 0.00 | 0.12 | +0.12 | buy |
| Qube Research & Technologies Ltd | 759,883 | 989,335 | +229,452 | 0.03 | 0.03 | -0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 217,857 | +217,857 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 190,421 | +190,421 | 0.00 | 0.04 | +0.04 | buy |
| Capital Research Global Investors | 2,565,897 | 2,734,923 | +169,026 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 12,963,151 | 13,130,494 | +167,343 | 0.02 | 0.01 | -0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 140,125 | +140,125 | 0.00 | 0.01 | +0.01 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 120,261 | 260,261 | +140,000 | 0.22 | 0.32 | +0.10 | buy |
| Aberdeen Group plc | 306,723 | 441,305 | +134,582 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 1,555,080 | 1,686,588 | +131,508 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 180,676 | 308,556 | +127,880 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,320,898 | 3,446,230 | +125,332 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 372,979 | 467,461 | +94,482 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,988,681 | 2,079,878 | +91,197 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 498,827 | 589,330 | +90,503 | 3.26 | 2.74 | -0.52 | buy |
| Fisher Asset Management, LLC | 876,599 | 965,031 | +88,432 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 38,692 | 124,217 | +85,525 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,627 | 129,735 | +79,108 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 249,702 | 324,020 | +74,318 | 0.02 | 0.02 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 284,267 | 357,600 | +73,333 | 0.01 | 0.01 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 66,999 | +66,999 | 0.00 | 0.35 | +0.35 | buy |
| JPMORGAN CHASE & CO | 274,693 | 330,593 | +55,900 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 38,690 | 84,991 | +46,301 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 423,774 | 468,578 | +44,804 | 0.03 | 0.02 | -0.01 | buy |
| Creative Planning | 18,399 | 61,017 | +42,618 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 16,066 | 56,204 | +40,138 | 0.01 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 16,066 | 56,204 | +40,138 | 0.17 | 0.28 | +0.10 | buy |
| CITIGROUP INC | 126,164 | 164,474 | +38,310 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 21,312 | 57,641 | +36,329 | 0.01 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 229,316 | 262,606 | +33,290 | 0.01 | 0.00 | -0.00 | buy |
| UBS Group AG | 418,485 | 450,147 | +31,662 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 56,108 | 86,893 | +30,785 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 94,138 | 122,460 | +28,322 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 1,184,467 | 1,209,865 | +25,398 | 0.10 | 0.07 | -0.02 | buy |
| Jump Financial, LLC | 114,902 | 138,855 | +23,953 | 0.06 | 0.04 | -0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 36,232 | 59,881 | +23,649 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 708 | 22,243 | +21,535 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 21,220 | +21,220 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 7,661 | 27,431 | +19,770 | 0.03 | 0.05 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 19,673 | +19,673 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 19,539 | +19,539 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 150,519 | 169,352 | +18,833 | 0.00 | 0.00 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 17,769 | 36,111 | +18,342 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 12,679 | 30,215 | +17,536 | 0.03 | 0.03 | -0.00 | buy |
| MPM BioImpact LLC | 414,035 | 430,161 | +16,126 | 1.51 | 1.21 | -0.30 | buy |
| VANGUARD GROUP INC | 5,078,084 | 5,092,619 | +14,535 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 56,691 | 70,968 | +14,277 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 75,417 | 89,558 | +14,141 | 0.23 | 0.14 | -0.09 | buy |
| Man Group plc | 0 | 13,811 | +13,811 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 56,466 | 69,831 | +13,365 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 11,908 | +11,908 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 7,904 | 19,174 | +11,270 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 113,561 | 124,437 | +10,876 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 81,174 | 90,780 | +9,606 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,726 | 81,278 | +9,552 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 25,300 | 34,300 | +9,000 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 13,509 | 22,402 | +8,893 | 0.13 | 0.12 | -0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 286,759 | 293,575 | +6,816 | 0.03 | 0.02 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,368 | +6,368 | 0.00 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 0 | 4,679 | +4,679 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 45,269 | 49,750 | +4,481 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 52,736 | 57,044 | +4,308 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 31,389 | 35,363 | +3,974 | 0.01 | 0.01 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 163 | 3,898 | +3,735 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 118,227 | 121,388 | +3,161 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 8,364 | 11,344 | +2,980 | 0.01 | 0.01 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 8,676 | 11,560 | +2,884 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 606 | 2,877 | +2,271 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 82,442 | 84,689 | +2,247 | 0.00 | 0.00 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 241,894 | 244,081 | +2,187 | 0.01 | 0.01 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 4,547 | 6,659 | +2,112 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 271 | 2,371 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 23,601 | 25,632 | +2,031 | 0.02 | 0.02 | -0.00 | buy |
| Mariner, LLC | 9,775 | 11,727 | +1,952 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,860 | +1,860 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 557 | 2,371 | +1,814 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 858 | 2,404 | +1,546 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 273 | 1,703 | +1,430 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,087 | 21,301 | +1,214 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 149,600 | 150,800 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 23,702 | 24,453 | +751 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 6,856 | 7,483 | +627 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 566 | +566 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,815 | 2,213 | +398 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 226,299 | 226,692 | +393 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 101,935 | 102,315 | +380 | 0.00 | 0.00 | -0.00 | buy |
| Fountainhead AM, LLC | 64,556 | 64,901 | +345 | 0.30 | 0.17 | -0.13 | buy |
| Corebridge Financial, Inc. | 41,992 | 42,333 | +341 | 0.01 | 0.00 | -0.00 | buy |
| Private Wealth Management Group, LLC | 0 | 323 | +323 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 97 | 387 | +290 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 22,049 | 22,285 | +236 | 0.00 | 0.00 | -0.00 | buy |