| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,149,960 | 13,172,103 | +22,143 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 8,209,392 | 8,442,133 | +232,741 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,186,456 | 7,265,253 | +78,797 | 0.11 | 0.12 | +0.00 | buy |
| Capital Research Global Investors | 5,279,675 | 5,163,543 | -116,132 | 0.03 | 0.03 | -0.01 | sell |
| BAKER BROS. ADVISORS LP | 3,618,826 | 3,946,515 | +327,689 | 0.73 | 0.76 | +0.02 | buy |
| STATE STREET CORP | 4,134,641 | 3,781,167 | -353,474 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 3,125,000 | 3,450,000 | +325,000 | 7.20 | 5.92 | -1.28 | buy |
| FEDERATED HERMES, INC. | 3,395,771 | 2,987,107 | -408,664 | 0.20 | 0.16 | -0.03 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,800,000 | 2,823,500 | +23,500 | 0.15 | 0.15 | -0.00 | buy |
| Fiera Capital Corp | 2,437,262 | 2,527,076 | +89,814 | 0.27 | 0.29 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,073,583 | 2,500,724 | +427,141 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,252,404 | 1,860,453 | +608,049 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,770,866 | 1,655,617 | -115,249 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,153,043 | 1,530,008 | -623,035 | 0.95 | 0.60 | -0.35 | sell |
| DIMENSIONAL FUND ADVISORS LP | 938,857 | 1,333,478 | +394,621 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,449,145 | 1,315,869 | -133,276 | 0.01 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 885,121 | 1,131,786 | +246,665 | 1.32 | 1.89 | +0.57 | buy |
| Candriam S.C.A. | 1,031,354 | 1,107,708 | +76,354 | 0.18 | 0.19 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 697,925 | 1,101,145 | +403,220 | 0.03 | 0.04 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 902,973 | 942,091 | +39,118 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 979,063 | 899,504 | -79,559 | 0.06 | 0.06 | -0.00 | sell |
| Fisher Asset Management, LLC | 889,633 | 882,699 | -6,934 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 723,653 | 873,838 | +150,185 | 2.86 | 3.25 | +0.39 | buy |
| UBS Group AG | 1,085,632 | 762,548 | -323,084 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 675,123 | 734,121 | +58,998 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 734,335 | 715,906 | -18,429 | 0.02 | 0.03 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,633 | 715,527 | +894 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 959,355 | 679,400 | -279,955 | 0.02 | 0.02 | -0.01 | sell |
| Qube Research & Technologies Ltd | 467,851 | 584,033 | +116,182 | 0.02 | 0.03 | +0.00 | buy |
| Aberdeen Group plc | 560,623 | 545,631 | -14,992 | 0.03 | 0.03 | -0.00 | sell |
| Redmile Group, LLC | 742,017 | 521,117 | -220,900 | 1.89 | 1.15 | -0.74 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 508,347 | 515,445 | +7,098 | 0.02 | 0.02 | +0.00 | buy |
| DAFNA Capital Management LLC | 506,740 | 476,740 | -30,000 | 4.07 | 3.61 | -0.46 | sell |
| TANG CAPITAL MANAGEMENT LLC | 450,000 | 450,000 | 0 | 0.77 | 0.76 | -0.01 | hold |
| Nuveen, LLC | 374,007 | 448,273 | +74,266 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 368,481 | 378,442 | +9,961 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,844,556 | 327,901 | -1,516,655 | 0.10 | 0.02 | -0.08 | sell |
| JPMORGAN CHASE & CO | 299,888 | 292,106 | -7,782 | 0.00 | 0.00 | -0.00 | sell |
| GENERAL AMERICAN INVESTORS CO INC | 280,261 | 280,261 | 0 | 0.60 | 0.62 | +0.01 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 277,560 | 256,318 | -21,242 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 255,764 | +255,764 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 250,000 | 255,500 | +5,500 | 0.81 | 1.05 | +0.24 | buy |
| Bank of New York Mellon Corp | 244,041 | 250,325 | +6,284 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 192,413 | 248,202 | +55,789 | 0.48 | 0.60 | +0.11 | buy |
| WELLS FARGO & COMPANY/MN | 256,144 | 243,328 | -12,816 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 204,398 | 241,508 | +37,110 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 240,209 | 230,268 | -9,941 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 208,548 | 228,980 | +20,432 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 596,483 | 208,345 | -388,138 | 0.04 | 0.01 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 202,434 | 202,434 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Woodline Partners LP | 201,667 | 201,667 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 192,308 | 192,308 | 0 | 0.02 | 0.02 | -0.00 | hold |
| WCM INVESTMENT MANAGEMENT, LLC | 219,268 | 181,593 | -37,675 | 0.02 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 48,920 | 177,272 | +128,352 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 174,124 | 175,151 | +1,027 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 23,826 | 171,846 | +148,020 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 162,733 | +162,733 | 0.00 | 0.17 | +0.17 | buy |
| ROYAL BANK OF CANADA | 165,323 | 161,837 | -3,486 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 163,407 | 157,270 | -6,137 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 155,600 | 155,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 136,055 | 145,028 | +8,973 | 0.00 | 0.00 | -0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 149,993 | 141,048 | -8,945 | 0.04 | 0.04 | -0.00 | sell |
| Russell Investments Group, Ltd. | 9,683 | 134,932 | +125,249 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 111,276 | 120,603 | +9,327 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 113,841 | 119,116 | +5,275 | 0.01 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 0 | 112,309 | +112,309 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 70,128 | 112,309 | +42,181 | 0.19 | 0.25 | +0.06 | buy |
| Invesco Ltd. | 238,314 | 111,112 | -127,202 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 107,625 | 107,383 | -242 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 97,886 | 100,786 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 99,278 | +99,278 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,945 | 96,655 | +20,710 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 120,604 | 91,637 | -28,967 | 0.96 | 0.77 | -0.19 | sell |
| CITIGROUP INC | 127,067 | 88,880 | -38,187 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 88,133 | +88,133 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 126,362 | 86,684 | -39,678 | 0.02 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 68,707 | 84,760 | +16,053 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,909 | 72,906 | +2,997 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 71,789 | 71,487 | -302 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 83,865 | 70,492 | -13,373 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 5,191 | 66,066 | +60,875 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 171,278 | 65,944 | -105,334 | 0.00 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 71,937 | 65,632 | -6,305 | 0.01 | 0.00 | -0.00 | sell |
| MML INVESTORS SERVICES, LLC | 83,939 | 58,950 | -24,989 | 0.01 | 0.01 | -0.00 | sell |
| AlphaCore Capital LLC | 6,757 | 57,406 | +50,649 | 0.01 | 0.05 | +0.04 | buy |
| XTX Topco Ltd | 66,175 | 56,622 | -9,553 | 0.06 | 0.03 | -0.03 | sell |
| Lido Advisors, LLC | 55,465 | 55,463 | -2 | 0.01 | 0.01 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 81,033 | 54,618 | -26,415 | 0.06 | 0.03 | -0.03 | sell |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Orion Porfolio Solutions, LLC | 58,394 | 49,357 | -9,037 | 0.01 | 0.01 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 48,234 | +48,234 | 0.00 | 1.14 | +1.14 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,558 | 46,709 | -16,849 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 44,079 | 46,687 | +2,608 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 45,813 | 46,404 | +591 | 0.01 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 46,142 | +46,142 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,683 | 45,865 | +1,182 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 44,954 | 45,263 | +309 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 46,040 | 43,670 | -2,370 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 43,096 | 42,979 | -117 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 47,938 | 42,705 | -5,233 | 0.01 | 0.01 | -0.00 | sell |