| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,466,587 | 2,502,673 | +1,036,086 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 657,897 | 1,667,523 | +1,009,626 | 0.01 | 0.02 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,743,628 | 2,268,628 | +525,000 | 0.53 | 1.14 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 832,769 | 1,062,123 | +229,354 | 0.06 | 0.14 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,676,559 | 2,575,110 | +101,449 | 0.08 | 0.13 | 0.00 | sell |
| Opaleye Management Inc. | 343,000 | 415,000 | +72,000 | 1.41 | 2.33 | +0.92 | buy |
| TWO SIGMA INVESTMENTS, LP | 324,410 | 271,931 | +52,479 | 0.01 | 0.02 | 0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 835,521 | 814,670 | +20,851 | 0.40 | 0.66 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 138,949 | 141,149 | +2,200 | 0.08 | 0.12 | 0.00 | buy |
| PROFUND ADVISORS LLC | 24,060 | 23,272 | +788 | 0.02 | 0.03 | 0.00 | sell |
| C M BIDWELL & ASSOCIATES LTD | 125 | 100 | +25 | 0.00 | 0.00 | +0.00 | sell |