| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 781,596 | 1,151,528 | +369,932 | 1.91 | 2.10 | +0.19 | buy |
| Avidity Partners Management LP | 799,700 | 1,117,000 | +317,300 | 1.13 | 1.67 | +0.54 | buy |
| JANUS HENDERSON GROUP PLC | 3,808,450 | 4,076,020 | +267,570 | 0.09 | 0.08 | 0.00 | buy |
| Holocene Advisors, LP | 1,615,648 | 1,871,873 | +256,225 | 0.26 | 0.27 | +0.01 | buy |
| Fiera Capital Corp | 1,089,400 | 1,335,410 | +246,010 | 0.14 | 0.15 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 658,024 | 884,538 | +226,514 | 0.04 | 0.05 | 0.00 | buy |
| Logos Global Management LP | 1,500,000 | 1,700,000 | +200,000 | 5.33 | 4.80 | -0.53 | buy |
| Capital Research Global Investors | 1,976,870 | 2,164,551 | +187,681 | 0.02 | 0.02 | -0.00 | buy |
| Soleus Capital Management, L.P. | 533,515 | 694,069 | +160,554 | 1.74 | 2.15 | +0.41 | buy |
| JENNISON ASSOCIATES LLC | 256,249 | 410,862 | +154,613 | 0.01 | 0.01 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 481,225 | 611,820 | +130,595 | 0.35 | 0.36 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 479,921 | 604,548 | +124,627 | 0.06 | 0.05 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 68,756 | 143,061 | +74,305 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 323,417 | 387,533 | +64,116 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 426,002 | 456,453 | +30,451 | 0.17 | 0.15 | -0.02 | buy |
| ALGERT GLOBAL LLC | 36,869 | 12,676 | +24,193 | 0.06 | 0.02 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 59,486 | 81,317 | +21,831 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 5,994 | 27,708 | +21,714 | 0.14 | 0.20 | +0.06 | buy |
| STEMPOINT CAPITAL LP | 87,393 | 101,787 | +14,394 | 1.02 | 1.05 | +0.03 | buy |
| Nebula Research & Development LLC | 19,664 | 32,370 | +12,706 | 0.19 | 0.18 | -0.00 | buy |
| PROFUND ADVISORS LLC | 31,922 | 22,823 | +9,099 | 0.06 | 0.03 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 52,045 | 60,050 | +8,005 | 0.17 | 0.13 | 0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,390 | 21,693 | +7,303 | 0.01 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 51,981 | 59,052 | +7,071 | 0.02 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 17,047 | 13,920 | +3,127 | 0.00 | 0.00 | 0.00 | sell |
| Orion Porfolio Solutions, LLC | 32,610 | 35,095 | +2,485 | 0.02 | 0.01 | 0.00 | buy |
| Bellevue Group AG | 3,300 | 5,700 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 52,492 | 54,392 | +1,900 | 0.56 | 0.49 | -0.08 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10,466 | 12,213 | +1,747 | 0.01 | 0.01 | 0.00 | buy |
| Dynamic Technology Lab Private Ltd | 5,645 | 6,087 | +442 | 0.03 | 0.02 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,535 | 2,325 | -210 | 0.06 | 0.04 | -0.02 | sell |
| Fisher Asset Management, LLC | 670,255 | 669,795 | -460 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 630,019 | 629,019 | -1,000 | 0.18 | 0.13 | -0.04 | sell |
| E Fund Management Co., Ltd. | 9,512 | 7,298 | -2,214 | 0.03 | 0.01 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 441,930 | 437,123 | -4,807 | 0.19 | 0.15 | -0.04 | sell |
| FRED ALGER MANAGEMENT, LLC | 16,882 | 11,994 | -4,888 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,347 | 8,893 | -5,454 | 0.08 | 0.04 | -0.04 | sell |
| Legato Capital Management LLC | 14,801 | 9,104 | -5,697 | 0.08 | 0.04 | -0.04 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 162,554 | 144,717 | -17,837 | 0.29 | 0.21 | -0.08 | sell |
| DAFNA Capital Management LLC | 446,341 | 422,213 | -24,128 | 4.46 | 3.54 | -0.92 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 49,000 | 14,500 | -34,500 | 0.01 | 0.00 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 97,422 | 52,047 | -45,375 | 0.09 | 0.04 | -0.05 | sell |
| HighVista Strategies LLC | 99,292 | 40,856 | -58,436 | 1.55 | 0.52 | -1.03 | sell |
| TD ASSET MANAGEMENT INC | 181,890 | 116,690 | -65,200 | 0.01 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 201,291 | 131,096 | -70,195 | 0.03 | 0.02 | -0.02 | sell |
| Nicholas Investment Partners, LP | 155,820 | 71,036 | -84,784 | 0.70 | 0.26 | -0.44 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 531,967 | 422,049 | -109,918 | 4.72 | 3.86 | -0.86 | sell |
| Redmile Group, LLC | 922,678 | 759,516 | -163,162 | 1.49 | 1.61 | +0.13 | sell |
| Cormorant Asset Management, LP | 450,000 | 245,000 | -205,000 | 0.87 | 0.50 | -0.37 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,052,500 | 3,743,741 | -308,759 | 0.02 | 0.02 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,467,107 | 2,065,094 | -402,013 | 0.20 | 0.13 | -0.07 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,630,292 | 2,097,113 | -533,179 | 2.01 | 1.23 | -0.78 | sell |