| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,155,254 | 11,270,083 | +1,114,829 | 0.03 | 0.03 | -0.00 | buy |
| Sofinnova Investments, Inc. | 781,596 | 1,151,528 | +369,932 | 2.02 | 2.55 | +0.52 | buy |
| Qube Research & Technologies Ltd | 60,515 | 388,252 | +327,737 | 0.00 | 0.03 | +0.02 | buy |
| Avidity Partners Management LP | 799,700 | 1,117,000 | +317,300 | 1.25 | 1.67 | +0.42 | buy |
| Pictet Asset Management Holding SA | 1,272,846 | 1,587,499 | +314,653 | 0.06 | 0.06 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 276,798 | +276,798 | 0.00 | 0.11 | +0.11 | buy |
| JANUS HENDERSON GROUP PLC | 3,808,450 | 4,076,020 | +267,570 | 0.09 | 0.08 | -0.01 | buy |
| MACQUARIE GROUP LTD | 0 | 258,170 | +258,170 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 418,899 | 676,734 | +257,835 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 1,615,648 | 1,871,873 | +256,225 | 0.26 | 0.27 | +0.01 | buy |
| Fiera Capital Corp | 1,089,400 | 1,335,410 | +246,010 | 0.14 | 0.15 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 658,024 | 884,538 | +226,514 | 0.04 | 0.04 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,565,715 | 1,772,617 | +206,902 | 0.01 | 0.01 | -0.00 | buy |
| Logos Global Management LP | 1,500,000 | 1,700,000 | +200,000 | 6.93 | 6.88 | -0.05 | buy |
| Capital Research Global Investors | 1,976,870 | 2,164,551 | +187,681 | 0.02 | 0.02 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 165,776 | +165,776 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 533,515 | 694,069 | +160,554 | 2.06 | 2.15 | +0.09 | buy |
| JENNISON ASSOCIATES LLC | 256,249 | 410,862 | +154,613 | 0.01 | 0.01 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 481,225 | 611,820 | +130,595 | 0.37 | 0.37 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 479,921 | 604,548 | +124,627 | 0.05 | 0.05 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 138,211 | 258,606 | +120,395 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 363,714 | 481,600 | +117,886 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,155,757 | 4,266,773 | +111,016 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 109,325 | +109,325 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 109,137 | +109,137 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 29,778 | 129,013 | +99,235 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 221,363 | 316,492 | +95,129 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 92,600 | +92,600 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 181,919 | 268,149 | +86,230 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,518 | 312,277 | +80,759 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 68,756 | 143,061 | +74,305 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 323,417 | 387,533 | +64,116 | 0.02 | 0.02 | -0.00 | buy |
| Squarepoint Ops LLC | 44,246 | 100,502 | +56,256 | 0.01 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 53,500 | +53,500 | 0.00 | 0.18 | +0.18 | buy |
| CITADEL ADVISORS LLC | 1,431,446 | 1,479,323 | +47,877 | 0.06 | 0.05 | -0.01 | buy |
| Magnetar Financial LLC | 0 | 45,550 | +45,550 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 569,589 | 610,555 | +40,966 | 0.01 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 53,724 | 90,482 | +36,758 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 304,912 | 335,772 | +30,860 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 426,002 | 456,453 | +30,451 | 0.17 | 0.15 | -0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 286,505 | 316,105 | +29,600 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 125,252 | 149,224 | +23,972 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 0 | 23,400 | +23,400 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 59,486 | 81,317 | +21,831 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 5,994 | 27,708 | +21,714 | 0.14 | 0.20 | +0.06 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 83,946 | 104,553 | +20,607 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 763,618 | 784,125 | +20,507 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,869 | 72,767 | +16,898 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 173,389 | 188,006 | +14,617 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 477 | 14,953 | +14,476 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 87,393 | 101,787 | +14,394 | 1.02 | 1.05 | +0.03 | buy |
| ASSETMARK, INC | 25,691 | 39,704 | +14,013 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 111,400 | 124,700 | +13,300 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,500 | 79,310 | +12,810 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 19,664 | 32,370 | +12,706 | 0.19 | 0.18 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 12,420 | +12,420 | 0.00 | 0.08 | +0.08 | buy |
| Snowden Capital Advisors LLC | 0 | 11,274 | +11,274 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 0 | 10,154 | +10,154 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 10,605 | 20,550 | +9,945 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,620 | 43,194 | +9,574 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 2,303 | 11,775 | +9,472 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 96,410 | 105,797 | +9,387 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 59,773 | 68,346 | +8,573 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 52,045 | 60,050 | +8,005 | 0.07 | 0.06 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,390 | 21,693 | +7,303 | 0.01 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 51,981 | 59,052 | +7,071 | 0.02 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 8,480 | 15,269 | +6,789 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 83,755 | 90,409 | +6,654 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 25,824 | 31,725 | +5,901 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,535 | 62,814 | +5,279 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 11,099 | 15,807 | +4,708 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 4,392 | +4,392 | 0.00 | 0.07 | +0.07 | buy |
| STIFEL FINANCIAL CORP | 25,170 | 29,424 | +4,254 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,453 | 15,633 | +3,180 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 32,610 | 35,095 | +2,485 | 0.02 | 0.01 | -0.00 | buy |
| Bellevue Group AG | 3,300 | 5,700 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 15,517 | 17,742 | +2,225 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 1,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 52,492 | 54,392 | +1,900 | 0.56 | 0.49 | -0.08 | buy |
| CI INVESTMENTS INC. | 0 | 1,786 | +1,786 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10,466 | 12,213 | +1,747 | 0.01 | 0.01 | -0.00 | buy |
| Daiwa Securities Group Inc. | 264 | 1,948 | +1,684 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,564 | 13,918 | +1,354 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 7,727 | 9,002 | +1,275 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 1,178 | +1,178 | 0.00 | 0.01 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,413 | 3,340 | +927 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,562 | 7,323 | +761 | 0.01 | 0.01 | -0.00 | buy |
| IFP Advisors, Inc | 3,732 | 4,403 | +671 | 0.01 | 0.01 | -0.00 | buy |
| Itau Unibanco Holding S.A. | 0 | 557 | +557 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 1,278 | 1,761 | +483 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 5,645 | 6,087 | +442 | 0.03 | 0.02 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 417 | +417 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 1,507 | 1,788 | +281 | 0.00 | 0.00 | -0.00 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 255 | +255 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 243,348 | 243,484 | +136 | 0.03 | 0.03 | -0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 98 | +98 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,221 | 2,310 | +89 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 946 | 1,025 | +79 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 5 | 77 | +72 | 0.00 | 0.00 | +0.00 | buy |