| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,130,494 | 13,137,294 | +6,800 | 0.01 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 9,156,517 | 8,842,635 | -313,882 | 0.00 | 0.00 | +0.00 | sell |
| Capital Research Global Investors | 2,734,923 | 6,552,691 | +3,817,768 | 0.01 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 6,401,781 | 6,206,238 | -195,543 | 0.06 | 0.06 | +0.00 | sell |
| Point72 Asset Management, L.P. | 140,125 | 5,028,279 | +4,888,154 | 0.01 | 0.25 | +0.24 | buy |
| VANGUARD GROUP INC | 5,092,619 | 4,941,945 | -150,674 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,767,926 | 4,627,266 | -140,660 | 0.17 | 0.18 | +0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,267,551 | 3,915,311 | +647,760 | 1.06 | 1.49 | +0.43 | buy |
| STATE STREET CORP | 3,446,230 | 3,385,794 | -60,436 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 3,500,000 | 3,345,000 | -155,000 | 10.19 | 9.39 | -0.80 | sell |
| Sofinnova Investments, Inc. | 2,622,192 | 2,147,795 | -474,397 | 3.24 | 3.07 | -0.17 | sell |
| BAKER BROS. ADVISORS LP | 1,062,123 | 2,118,728 | +1,056,605 | 0.19 | 0.43 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,079,878 | 2,113,164 | +33,286 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,475,622 | 1,904,916 | -1,570,706 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,505,080 | 1,825,903 | +320,823 | 0.02 | 0.03 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,838,764 | 1,805,136 | -33,628 | 0.03 | 0.04 | +0.01 | sell |
| Fiera Capital Corp | 1,209,865 | 1,532,269 | +322,404 | 0.07 | 0.11 | +0.04 | buy |
| MORGAN STANLEY | 1,686,588 | 1,453,377 | -233,211 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,188,094 | 1,238,094 | +50,000 | 0.04 | 0.04 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 816,222 | 1,228,184 | +411,962 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,185,186 | 923,705 | -261,481 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 965,031 | 922,092 | -42,939 | 0.01 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 938,177 | 914,400 | -23,777 | 0.10 | 0.11 | +0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 771,844 | 771,844 | 0 | 0.25 | 0.28 | +0.03 | hold |
| UBS Group AG | 450,147 | 751,905 | +301,758 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 327,644 | 741,833 | +414,189 | 0.01 | 0.03 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 703,716 | 716,798 | +13,082 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 753,529 | 715,356 | -38,173 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 589,330 | 619,090 | +29,760 | 2.74 | 3.59 | +0.86 | buy |
| Qube Research & Technologies Ltd | 989,335 | 525,878 | -463,457 | 0.03 | 0.02 | -0.01 | sell |
| Rosalind Advisors, Inc. | 700,000 | 511,132 | -188,868 | 5.59 | 5.20 | -0.39 | sell |
| JPMORGAN CHASE & CO | 330,593 | 446,420 | +115,827 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 441,305 | 441,305 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Redmile Group, LLC | 534,600 | 432,494 | -102,106 | 0.83 | 0.97 | +0.14 | sell |
| DEUTSCHE BANK AG\ | 467,461 | 415,399 | -52,062 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 331,072 | 401,692 | +70,620 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 122,460 | 377,772 | +255,312 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 324,020 | 324,543 | +523 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 185,366 | 321,166 | +135,800 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 293,575 | 283,811 | -9,764 | 0.02 | 0.02 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 303,145 | 272,660 | -30,485 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 413,600 | 266,600 | -147,000 | 0.02 | 0.01 | -0.00 | sell |
| GENERAL AMERICAN INVESTORS CO INC | 260,261 | 260,261 | 0 | 0.32 | 0.37 | +0.05 | hold |
| ALGERT GLOBAL LLC | 306,708 | 253,080 | -53,628 | 0.12 | 0.11 | -0.01 | sell |
| Soleus Capital Management, L.P. | 0 | 250,000 | +250,000 | 0.00 | 0.36 | +0.36 | buy |
| Bank of New York Mellon Corp | 226,692 | 249,847 | +23,155 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 244,081 | 239,738 | -4,343 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 315,372 | 226,390 | -88,982 | 0.03 | 0.03 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 262,606 | 220,952 | -41,654 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 287,314 | 217,320 | -69,994 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 169,352 | 217,134 | +47,782 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 209,551 | +209,551 | 0.00 | 0.03 | +0.03 | buy |
| SummitTX Capital, L.P. | 132,423 | 207,209 | +74,786 | 0.10 | 0.19 | +0.10 | buy |
| DIMENSIONAL FUND ADVISORS LP | 81,197 | 170,672 | +89,475 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 152,713 | 166,917 | +14,204 | 0.14 | 0.23 | +0.09 | buy |
| STEMPOINT CAPITAL LP | 66,999 | 165,885 | +98,886 | 0.35 | 1.12 | +0.77 | buy |
| TWO SIGMA INVESTMENTS, LP | 468,578 | 156,639 | -311,939 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 150,800 | 150,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Foresite Capital Management VI LLC | 0 | 144,468 | +144,468 | 0.00 | 1.71 | +1.71 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 129,735 | 143,945 | +14,210 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 124,437 | 131,149 | +6,712 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 123,000 | 124,230 | +1,230 | 0.61 | 1.05 | +0.44 | buy |
| Creative Planning | 61,017 | 121,684 | +60,667 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,908 | 114,644 | +102,736 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 121,388 | 109,807 | -11,581 | 0.01 | 0.01 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 97,403 | 109,155 | +11,752 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 90,780 | 100,827 | +10,047 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 308,556 | 98,153 | -210,403 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 97,830 | 97,830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 84,689 | 85,923 | +1,234 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 48,627 | 85,178 | +36,551 | 0.02 | 0.04 | +0.02 | buy |
| Invesco Ltd. | 70,968 | 83,982 | +13,014 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 43,300 | 83,288 | +39,988 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 81,278 | 82,532 | +1,254 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,310 | 71,184 | -1,126 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 56,204 | 69,694 | +13,490 | 0.02 | 0.02 | +0.00 | buy |
| TEMA ETFS LLC | 56,204 | 69,694 | +13,490 | 0.28 | 0.39 | +0.11 | buy |
| Man Group plc | 13,811 | 68,043 | +54,232 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 547,637 | 66,686 | -480,951 | 0.01 | 0.00 | -0.01 | sell |
| Fountainhead AM, LLC | 64,901 | 64,901 | 0 | 0.17 | 0.20 | +0.03 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,831 | 64,808 | -5,023 | 0.00 | 0.00 | +0.00 | sell |
| ASSETMARK, INC | 49,750 | 62,586 | +12,836 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 164,474 | 61,750 | -102,724 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 86,893 | 60,887 | -26,006 | 0.01 | 0.01 | -0.00 | sell |
| Nebula Research & Development LLC | 89,558 | 60,767 | -28,791 | 0.14 | 0.11 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 124,217 | 59,206 | -65,011 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 69,474 | 51,600 | -17,874 | 0.03 | 0.03 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 57,044 | 51,284 | -5,760 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 50,891 | +50,891 | 0.00 | 0.03 | +0.03 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 49,941 | 49,941 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ALPS ADVISORS INC | 61,538 | 47,243 | -14,295 | 0.01 | 0.01 | -0.00 | sell |
| Orion Porfolio Solutions, LLC | 36,111 | 44,625 | +8,514 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 269,064 | 40,450 | -228,614 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 59,881 | 39,491 | -20,390 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 38,720 | +38,720 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 84,991 | 37,690 | -47,301 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 89,326 | 37,389 | -51,937 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 36,486 | 35,835 | -651 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 35,036 | 35,036 | 0 | 0.00 | 0.00 | +0.00 | hold |