| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 2,734,923 | 6,552,691 | +3,817,768 | 0.01 | 0.03 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 1,062,123 | 2,118,728 | +1,056,605 | 0.19 | 0.43 | +0.24 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,267,551 | 3,915,311 | +647,760 | 1.06 | 1.49 | +0.44 | buy |
| Fiera Capital Corp | 1,209,865 | 1,532,269 | +322,404 | 0.07 | 0.11 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 6,401,781 | 6,206,238 | +195,543 | 0.06 | 0.06 | 0.00 | sell |
| STEMPOINT CAPITAL LP | 66,999 | 165,885 | +98,886 | 0.35 | 1.12 | +0.77 | buy |
| SummitTX Capital, L.P. | 132,423 | 207,209 | +74,786 | 0.09 | 0.19 | +0.09 | buy |
| ALGERT GLOBAL LLC | 306,708 | 253,080 | +53,628 | 0.13 | 0.11 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,188,094 | 1,238,094 | +50,000 | 0.04 | 0.04 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 262,606 | 220,952 | +41,654 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 589,330 | 619,090 | +29,760 | 2.74 | 3.59 | +0.86 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 69,474 | 51,600 | +17,874 | 0.09 | 0.06 | 0.00 | sell |
| ALPS ADVISORS INC | 61,538 | 47,243 | +14,295 | 0.01 | 0.01 | 0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 152,713 | 166,917 | +14,204 | 0.14 | 0.23 | +0.09 | buy |
| NEOS Investment Management LLC | 56,204 | 69,694 | +13,490 | 0.02 | 0.02 | +0.00 | buy |
| TEMA ETFS LLC | 56,204 | 69,694 | +13,490 | 0.28 | 0.39 | +0.11 | buy |
| Sio Capital Management, LLC | 123,000 | 124,230 | +1,230 | 0.60 | 1.00 | +0.40 | buy |
| E Fund Management Co., Ltd. | 11,344 | 12,225 | +881 | 0.01 | 0.01 | +0.00 | buy |
| Fourth Dimension Wealth, LLC | 100 | 150 | +50 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,558 | 17,590 | +32 | 0.03 | 0.03 | +0.01 | buy |
| MEEDER ASSET MANAGEMENT INC | 175 | 136 | -39 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 6,368 | 4,220 | -2,148 | 0.03 | 0.03 | +0.00 | sell |
| PROFUND ADVISORS LLC | 25,632 | 23,375 | -2,257 | 0.02 | 0.02 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 244,081 | 239,738 | -4,343 | 0.01 | 0.01 | +0.00 | sell |
| Palumbo Wealth Management LLC | 22,402 | 15,782 | -6,620 | 0.12 | 0.10 | -0.02 | sell |
| Rafferty Asset Management, LLC | 121,388 | 109,807 | -11,581 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 938,177 | 914,400 | -23,777 | 0.10 | 0.11 | +0.01 | sell |
| Nebula Research & Development LLC | 89,558 | 60,767 | -28,791 | 0.14 | 0.11 | -0.03 | sell |
| BIT Capital GmbH | 42,715 | 4,220 | -38,495 | 0.06 | 0.01 | -0.05 | sell |
| Fisher Asset Management, LLC | 965,031 | 922,092 | -42,939 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 315,372 | 226,390 | -88,982 | 0.03 | 0.03 | -0.01 | sell |
| Redmile Group, LLC | 534,600 | 432,494 | -102,106 | 0.83 | 0.97 | +0.14 | sell |
| Logos Global Management LP | 3,500,000 | 3,345,000 | -155,000 | 10.19 | 9.39 | -0.80 | sell |
| Rosalind Advisors, Inc. | 700,000 | 511,132 | -188,868 | 5.58 | 5.09 | -0.48 | sell |
| Sofinnova Investments, Inc. | 2,622,192 | 2,147,795 | -474,397 | 2.81 | 2.76 | -0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,475,622 | 1,904,916 | -1,570,706 | 0.01 | 0.00 | -0.00 | sell |