| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALLIANCEBERNSTEIN L.P. | 100,786 | 1,627,521 | +1,526,735 | 0.00 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,530,008 | 2,714,503 | +1,184,495 | 0.60 | 1.06 | +0.45 | buy |
| BAKER BROS. ADVISORS LP | 3,946,515 | 5,010,030 | +1,063,515 | 0.76 | 0.94 | +0.18 | buy |
| FMR LLC | 13,172,103 | 14,109,431 | +937,328 | 0.02 | 0.02 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 891,608 | +891,608 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,315,869 | 2,207,451 | +891,582 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,781,167 | 4,548,911 | +767,744 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 754,888 | +754,888 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 480,383 | +480,383 | 0.00 | 3.07 | +3.07 | buy |
| BlackRock, Inc. | 8,442,133 | 8,893,260 | +451,127 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.73 | +0.73 | buy |
| Walleye Capital LLC | 0 | 386,183 | +386,183 | 0.00 | 0.07 | +0.07 | buy |
| RTW INVESTMENTS, LP | 0 | 370,370 | +370,370 | 0.00 | 0.12 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,333,478 | 1,661,281 | +327,803 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 311,333 | +311,333 | 0.00 | 0.40 | +0.40 | buy |
| FIRST TRUST ADVISORS LP | 46,687 | 306,729 | +260,042 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.27 | +0.27 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 196,408 | +196,408 | 0.00 | 1.05 | +1.05 | buy |
| Nuveen, LLC | 448,273 | 640,257 | +191,984 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 184,054 | +184,054 | 0.00 | 0.05 | +0.05 | buy |
| Capital Research Global Investors | 5,163,543 | 5,344,701 | +181,158 | 0.03 | 0.03 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,101,145 | 1,269,889 | +168,744 | 0.04 | 0.05 | +0.00 | buy |
| Rheos Capital Works Inc. | 0 | 150,000 | +150,000 | 0.00 | 0.32 | +0.32 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 65,944 | 187,017 | +121,073 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 521,117 | 640,202 | +119,085 | 1.15 | 1.60 | +0.45 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 117,713 | +117,713 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,317 | 124,118 | +109,801 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 12,727 | 112,800 | +100,073 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 208,345 | 297,565 | +89,220 | 0.01 | 0.02 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 255,500 | 343,800 | +88,300 | 1.05 | 1.21 | +0.16 | buy |
| BANK OF AMERICA CORP /DE/ | 942,091 | 1,026,143 | +84,052 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 43,670 | 118,670 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 171,846 | 245,492 | +73,646 | 0.01 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 1,860,453 | 1,931,491 | +71,038 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 734,121 | 804,118 | +69,997 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 67,500 | +67,500 | 0.00 | 3.24 | +3.24 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 65,000 | +65,000 | 0.00 | 0.03 | +0.03 | buy |
| Atle Fund Management AB | 31,133 | 94,478 | +63,345 | 1.30 | 0.95 | -0.35 | buy |
| Jump Financial, LLC | 0 | 56,109 | +56,109 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 243,328 | 297,848 | +54,520 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.08 | +0.08 | buy |
| Phocas Financial Corp. | 0 | 48,822 | +48,822 | 0.00 | 0.25 | +0.25 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 91,637 | 138,708 | +47,071 | 0.77 | 1.27 | +0.50 | buy |
| SummitTX Capital, L.P. | 162,733 | 204,872 | +42,139 | 0.17 | 0.20 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,527 | 754,888 | +39,361 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,906 | 107,585 | +34,679 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 111,112 | 145,220 | +34,108 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 0 | 30,589 | +30,589 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 30,529 | +30,529 | 0.00 | 0.04 | +0.04 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 8,850 | 38,950 | +30,100 | 0.00 | 0.01 | +0.01 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 280,261 | 308,240 | +27,979 | 0.62 | 0.70 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 42,163 | 67,976 | +25,813 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 46,142 | 70,360 | +24,218 | 0.04 | 0.06 | +0.02 | buy |
| Tidal Investments LLC | 112,309 | 135,847 | +23,538 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 112,309 | 135,847 | +23,538 | 0.25 | 0.16 | -0.09 | buy |
| CenterBook Partners LP | 0 | 22,815 | +22,815 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 88,880 | 110,970 | +22,090 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 21,800 | +21,800 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 20,763 | +20,763 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 20,500 | +20,500 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 476,740 | 497,240 | +20,500 | 3.61 | 3.53 | -0.08 | buy |
| AXQ CAPITAL, LP | 0 | 20,207 | +20,207 | 0.00 | 0.08 | +0.08 | buy |
| Allianz Asset Management GmbH | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 23,162 | 42,455 | +19,293 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 71,487 | 88,769 | +17,282 | 0.01 | 0.02 | +0.00 | buy |
| Atom Investors LP | 37,797 | 54,913 | +17,116 | 0.09 | 0.18 | +0.09 | buy |
| INCEPTIONR LLC | 0 | 15,807 | +15,807 | 0.00 | 0.14 | +0.14 | buy |
| Aberdeen Group plc | 545,631 | 560,934 | +15,303 | 0.03 | 0.03 | +0.00 | buy |
| Bank of New York Mellon Corp | 250,325 | 265,203 | +14,878 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 14,063 | +14,063 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 10,183 | +10,183 | 0.00 | 0.09 | +0.09 | buy |
| Legal & General Group Plc | 70,492 | 80,461 | +9,969 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 6,181 | 15,065 | +8,884 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 584,033 | 592,473 | +8,440 | 0.03 | 0.02 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 39,530 | 47,328 | +7,798 | 0.07 | 0.09 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 6,627 | +6,627 | 0.00 | 0.02 | +0.02 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 5,686 | +5,686 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 5,656 | +5,656 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 145,028 | 150,582 | +5,554 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,383 | 111,764 | +4,381 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,021 | +4,021 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 29,800 | 33,800 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 3,901 | +3,901 | 0.00 | 0.01 | +0.01 | buy |
| Freestone Grove Partners LP | 0 | 3,778 | +3,778 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 7,866 | 11,435 | +3,569 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 3,417 | +3,417 | 0.00 | 0.02 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 17,093 | 20,454 | +3,361 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 30,900 | 34,200 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,014 | 11,290 | +3,276 | 0.07 | 0.10 | +0.02 | buy |
| Swiss National Bank | 155,600 | 158,600 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 42,705 | 45,287 | +2,582 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 46,404 | 48,840 | +2,436 | 0.01 | 0.01 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 15,614 | 17,876 | +2,262 | 0.01 | 0.01 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 202,434 | 204,659 | +2,225 | 0.10 | 0.12 | +0.02 | buy |
| PEAK6 LLC | 0 | 2,017 | +2,017 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 18,863 | 20,772 | +1,909 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 14,501 | 16,283 | +1,782 | 0.01 | 0.00 | -0.00 | buy |