| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,172,103 | 14,109,431 | +937,328 | 0.02 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 8,442,133 | 8,893,260 | +451,127 | 0.00 | 0.00 | +0.00 | buy |
| Capital Research Global Investors | 5,163,543 | 5,344,701 | +181,158 | 0.03 | 0.03 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,946,515 | 5,010,030 | +1,063,515 | 0.76 | 0.94 | +0.18 | buy |
| STATE STREET CORP | 3,781,167 | 4,548,911 | +767,744 | 0.00 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 3,450,000 | 3,000,000 | -450,000 | 5.92 | 4.81 | -1.11 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,823,500 | 2,715,391 | -108,109 | 0.15 | 0.14 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,530,008 | 2,714,503 | +1,184,495 | 0.60 | 1.06 | +0.45 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,500,724 | 2,425,602 | -75,122 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,315,869 | 2,207,451 | +891,582 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,860,453 | 1,931,491 | +71,038 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,333,478 | 1,661,281 | +327,803 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,786 | 1,627,521 | +1,526,735 | 0.00 | 0.02 | +0.02 | buy |
| Fiera Capital Corp | 2,527,076 | 1,445,885 | -1,081,191 | 0.29 | 0.20 | -0.09 | sell |
| FEDERATED HERMES, INC. | 2,987,107 | 1,431,630 | -1,555,477 | 0.16 | 0.08 | -0.09 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,101,145 | 1,269,889 | +168,744 | 0.04 | 0.05 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,655,617 | 1,231,614 | -424,003 | 0.01 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 1,107,708 | 1,092,301 | -15,407 | 0.19 | 0.18 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 942,091 | 1,026,143 | +84,052 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,131,786 | 925,119 | -206,667 | 1.89 | 1.84 | -0.05 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 891,608 | +891,608 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 882,699 | 851,306 | -31,393 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 734,121 | 804,118 | +69,997 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 754,888 | +754,888 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,527 | 754,888 | +39,361 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 715,906 | 712,674 | -3,232 | 0.03 | 0.03 | +0.00 | sell |
| UBS Group AG | 762,548 | 656,721 | -105,827 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 448,273 | 640,257 | +191,984 | 0.00 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 521,117 | 640,202 | +119,085 | 1.15 | 1.60 | +0.45 | buy |
| Qube Research & Technologies Ltd | 584,033 | 592,473 | +8,440 | 0.03 | 0.02 | -0.00 | buy |
| Aberdeen Group plc | 545,631 | 560,934 | +15,303 | 0.03 | 0.03 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 515,445 | 501,990 | -13,455 | 0.02 | 0.02 | -0.00 | sell |
| DAFNA Capital Management LLC | 476,740 | 497,240 | +20,500 | 3.61 | 3.53 | -0.08 | buy |
| Sio Capital Management, LLC | 0 | 480,383 | +480,383 | 0.00 | 3.07 | +3.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 450,000 | 450,000 | 0 | 0.76 | 0.76 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.73 | +0.73 | buy |
| Walleye Capital LLC | 0 | 386,183 | +386,183 | 0.00 | 0.07 | +0.07 | buy |
| RTW INVESTMENTS, LP | 0 | 370,370 | +370,370 | 0.00 | 0.12 | +0.12 | buy |
| Rhenman & Partners Asset Management AB | 255,500 | 343,800 | +88,300 | 1.05 | 1.21 | +0.16 | buy |
| BIT Capital GmbH | 0 | 311,333 | +311,333 | 0.00 | 0.40 | +0.40 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 280,261 | 308,240 | +27,979 | 0.62 | 0.70 | +0.08 | buy |
| FIRST TRUST ADVISORS LP | 46,687 | 306,729 | +260,042 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 679,400 | 300,438 | -378,962 | 0.02 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 243,328 | 297,848 | +54,520 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 208,345 | 297,565 | +89,220 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 292,106 | 267,494 | -24,612 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 899,504 | 267,182 | -632,322 | 0.06 | 0.02 | -0.04 | sell |
| Bank of New York Mellon Corp | 250,325 | 265,203 | +14,878 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 255,764 | 248,559 | -7,205 | 0.01 | 0.01 | -0.00 | sell |
| Man Group plc | 171,846 | 245,492 | +73,646 | 0.01 | 0.02 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 230,268 | 230,209 | -59 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 256,318 | 224,109 | -32,209 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 241,508 | 209,394 | -32,114 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 162,733 | 204,872 | +42,139 | 0.17 | 0.20 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 202,434 | 204,659 | +2,225 | 0.10 | 0.12 | +0.02 | buy |
| Woodline Partners LP | 201,667 | 201,667 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.27 | +0.27 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 196,408 | +196,408 | 0.00 | 1.05 | +1.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 65,944 | 187,017 | +121,073 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 184,054 | +184,054 | 0.00 | 0.05 | +0.05 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 181,593 | 173,785 | -7,808 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 155,600 | 158,600 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 161,837 | 158,152 | -3,685 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 157,270 | 151,380 | -5,890 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 145,028 | 150,582 | +5,554 | 0.00 | 0.00 | +0.00 | buy |
| Rheos Capital Works Inc. | 0 | 150,000 | +150,000 | 0.00 | 0.32 | +0.32 | buy |
| Invesco Ltd. | 111,112 | 145,220 | +34,108 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 175,151 | 143,285 | -31,866 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 91,637 | 138,708 | +47,071 | 0.77 | 1.27 | +0.50 | buy |
| Tidal Investments LLC | 112,309 | 135,847 | +23,538 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 112,309 | 135,847 | +23,538 | 0.25 | 0.16 | -0.09 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,317 | 124,118 | +109,801 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 43,670 | 118,670 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 117,713 | +117,713 | 0.00 | 0.03 | +0.03 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 12,727 | 112,800 | +100,073 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 107,383 | 111,764 | +4,381 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 88,880 | 110,970 | +22,090 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,906 | 107,585 | +34,679 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| Atle Fund Management AB | 31,133 | 94,478 | +63,345 | 1.30 | 0.95 | -0.35 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 96,655 | 93,936 | -2,719 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 378,442 | 93,844 | -284,598 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 177,272 | 90,135 | -87,137 | 0.01 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 71,487 | 88,769 | +17,282 | 0.01 | 0.02 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 141,048 | 87,747 | -53,301 | 0.04 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 70,492 | 80,461 | +9,969 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 46,142 | 70,360 | +24,218 | 0.04 | 0.06 | +0.02 | buy |
| SEI INVESTMENTS CO | 84,760 | 68,986 | -15,774 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 42,163 | 67,976 | +25,813 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 67,500 | +67,500 | 0.00 | 3.24 | +3.24 | buy |
| ASSETMARK, INC | 65,632 | 65,021 | -611 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 65,000 | +65,000 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 86,684 | 64,150 | -22,534 | 0.01 | 0.01 | -0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 66,066 | 59,780 | -6,286 | 0.00 | 0.00 | -0.00 | sell |
| MML INVESTORS SERVICES, LLC | 58,950 | 58,047 | -903 | 0.01 | 0.00 | -0.00 | sell |
| AlphaCore Capital LLC | 57,406 | 57,077 | -329 | 0.05 | 0.04 | -0.01 | sell |
| Jump Financial, LLC | 0 | 56,109 | +56,109 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 37,797 | 54,913 | +17,116 | 0.09 | 0.18 | +0.09 | buy |
| XTX Topco Ltd | 56,622 | 51,239 | -5,383 | 0.03 | 0.02 | -0.01 | sell |
| Lido Advisors, LLC | 55,463 | 51,212 | -4,251 | 0.01 | 0.01 | -0.00 | sell |