| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 723,802 | 1,376,870 | +653,068 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,502,673 | 3,030,369 | +527,696 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 1,750,000 | 2,250,000 | +500,000 | 5.68 | 8.66 | +2.98 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 262,436 | 697,461 | +435,025 | 0.08 | 0.24 | +0.17 | buy |
| Sofinnova Investments, Inc. | 664,746 | 1,037,187 | +372,441 | 1.03 | 1.94 | +0.91 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 496,433 | 570,682 | +74,249 | 4.19 | 4.86 | +0.67 | buy |
| Woodline Partners LP | 177,024 | 240,428 | +63,404 | 0.05 | 0.08 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 1,667,523 | 1,723,160 | +55,637 | 0.02 | 0.03 | 0.00 | buy |
| Informed Momentum Co LLC | 35,363 | 87,662 | +52,299 | 0.15 | 0.46 | +0.30 | buy |
| ALGERT GLOBAL LLC | 65,089 | 42,619 | +22,470 | 0.07 | 0.05 | 0.00 | sell |
| DAFNA Capital Management LLC | 479,820 | 499,820 | +20,000 | 3.08 | 4.19 | +1.11 | buy |
| Candriam S.C.A. | 410,020 | 430,019 | +19,999 | 0.07 | 0.08 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 141,149 | 126,149 | +15,000 | 0.12 | 0.09 | 0.00 | sell |
| Campbell & CO Investment Adviser LLC | 21,184 | 31,690 | +10,506 | 0.09 | 0.10 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 127,339 | 132,701 | +5,362 | 0.52 | 0.66 | +0.14 | buy |
| Rafferty Asset Management, LLC | 125,017 | 129,076 | +4,059 | 0.02 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 751 | 1,474 | +723 | 0.01 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18,346 | 18,802 | +456 | 0.00 | 0.00 | 0.00 | buy |
| ALPS ADVISORS INC | 42,111 | 42,479 | +368 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,378 | 3,977 | -401 | 0.06 | 0.07 | +0.00 | sell |
| Sio Capital Management, LLC | 74,594 | 74,007 | -587 | 0.62 | 0.62 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 16,000 | 15,200 | -800 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 23,272 | 22,343 | -929 | 0.03 | 0.03 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 814,670 | 766,682 | -47,988 | 0.66 | 0.81 | +0.14 | sell |
| Opaleye Management Inc. | 415,000 | 311,500 | -103,500 | 2.33 | 2.73 | +0.40 | sell |
| Ikarian Capital, LLC | 490,893 | 216,949 | -273,944 | 4.07 | 2.17 | -1.90 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,575,110 | 2,286,961 | -288,149 | 0.13 | 0.14 | +0.01 | sell |
| BVF INC/IL | 5,683,489 | 5,283,489 | -400,000 | 3.72 | 3.84 | +0.12 | sell |
| Avidity Partners Management LP | 2,985,700 | 2,144,971 | -840,729 | 2.45 | 2.33 | -0.12 | sell |