| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,076,020 | 5,162,376 | +1,086,356 | 0.08 | 0.08 | 0.00 | buy |
| Sofinnova Investments, Inc. | 1,151,528 | 1,749,455 | +597,927 | 2.10 | 4.40 | +2.30 | buy |
| JENNISON ASSOCIATES LLC | 410,862 | 972,266 | +561,404 | 0.01 | 0.02 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,097,113 | 2,594,000 | +496,887 | 1.23 | 1.23 | +0.00 | buy |
| Capital Research Global Investors | 2,164,551 | 2,566,356 | +401,805 | 0.02 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 1,700,000 | 2,100,000 | +400,000 | 6.88 | 7.45 | +0.58 | buy |
| Soleus Capital Management, L.P. | 694,069 | 1,049,314 | +355,245 | 2.15 | 2.76 | +0.62 | buy |
| Candriam S.C.A. | 629,019 | 940,440 | +311,421 | 0.13 | 0.17 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,743,741 | 4,015,298 | +271,557 | 0.02 | 0.01 | -0.00 | buy |
| Avidity Partners Management LP | 1,117,000 | 1,373,000 | +256,000 | 1.67 | 2.22 | +0.55 | buy |
| Qube Research & Technologies Ltd | 388,252 | 639,609 | +251,357 | 0.03 | 0.04 | 0.00 | buy |
| BVF INC/IL | 1,162,306 | 1,409,993 | +247,687 | 1.14 | 1.31 | +0.16 | buy |
| SAMLYN CAPITAL, LLC | 611,820 | 817,307 | +205,487 | 0.36 | 0.39 | +0.03 | buy |
| Fisher Asset Management, LLC | 669,795 | 848,909 | +179,114 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 456,453 | 588,754 | +132,301 | 0.15 | 0.16 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 276,798 | 395,488 | +118,690 | 0.11 | 0.13 | 0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 422,049 | 531,630 | +109,581 | 3.86 | 4.37 | +0.50 | buy |
| TWINBEECH CAPITAL LP | 52,047 | 159,466 | +107,419 | 0.04 | 0.10 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 604,548 | 498,590 | +105,958 | 0.05 | 0.04 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 143,061 | 243,853 | +100,792 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 53,500 | 127,500 | +74,000 | 0.18 | 0.33 | +0.15 | buy |
| DAFNA Capital Management LLC | 422,213 | 471,410 | +49,197 | 3.54 | 3.53 | -0.01 | buy |
| Nebula Research & Development LLC | 32,370 | 70,763 | +38,393 | 0.18 | 0.27 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 81,317 | 50,370 | +30,947 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 101,787 | 132,703 | +30,916 | 1.05 | 1.26 | +0.21 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 60,050 | 48,604 | +11,446 | 0.13 | 0.12 | 0.00 | sell |
| Artia Global Partners LP | 54,392 | 62,992 | +8,600 | 0.49 | 0.56 | +0.07 | buy |
| China Universal Asset Management Co., Ltd. | 8,893 | 16,249 | +7,356 | 0.04 | 0.06 | +0.01 | buy |
| ProShare Advisors LLC | 13,920 | 21,130 | +7,210 | 0.00 | 0.00 | 0.00 | buy |
| ALPS ADVISORS INC | 59,052 | 64,890 | +5,838 | 0.01 | 0.01 | -0.00 | buy |
| NEOS Investment Management LLC | 10,154 | 14,489 | +4,335 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 22,823 | 25,574 | +2,751 | 0.03 | 0.03 | 0.00 | buy |
| Bellevue Group AG | 5,700 | 7,200 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 7,298 | 8,097 | +799 | 0.01 | 0.01 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 300 | 1,000 | +700 | 0.00 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 12,213 | 12,058 | +155 | 0.01 | 0.00 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,325 | 2,369 | +44 | 0.04 | 0.04 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 98 | 124 | +26 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 1,786 | 1,799 | +13 | 0.00 | 0.00 | 0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 21,693 | 21,678 | -15 | 0.02 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 131,096 | 126,019 | -5,077 | 0.02 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 116,690 | 82,090 | -34,600 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 71,036 | 29,625 | -41,411 | 0.26 | 0.09 | -0.17 | sell |
| Fiera Capital Corp | 1,335,410 | 1,289,820 | -45,590 | 0.15 | 0.12 | -0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 387,533 | 331,072 | -56,461 | 0.02 | 0.01 | -0.00 | sell |
| Redmile Group, LLC | 759,516 | 681,150 | -78,366 | 1.61 | 1.27 | -0.34 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,065,094 | 980,094 | -1,085,000 | 0.13 | 0.05 | -0.08 | sell |
| Holocene Advisors, LP | 1,871,873 | 562,848 | -1,309,025 | 0.27 | 0.07 | -0.20 | sell |