| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,270,083 | 12,635,653 | +1,365,570 | 0.03 | 0.02 | -0.00 | buy |
| FEDERATED HERMES, INC. | 4,855,790 | 5,208,300 | +352,510 | 0.40 | 0.36 | -0.04 | buy |
| JANUS HENDERSON GROUP PLC | 4,076,020 | 5,162,376 | +1,086,356 | 0.08 | 0.08 | +0.01 | buy |
| VANGUARD GROUP INC | 4,266,773 | 4,795,148 | +528,375 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,743,741 | 4,015,298 | +271,557 | 0.02 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,874,296 | 3,317,936 | +443,640 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,097,113 | 2,594,000 | +496,887 | 1.23 | 1.23 | +0.00 | buy |
| Capital Research Global Investors | 2,164,551 | 2,566,356 | +401,805 | 0.02 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 1,700,000 | 2,100,000 | +400,000 | 6.88 | 7.45 | +0.58 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,772,617 | 1,945,455 | +172,838 | 0.01 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,587,499 | 1,894,340 | +306,841 | 0.06 | 0.07 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,151,528 | 1,749,455 | +597,927 | 2.55 | 4.59 | +2.04 | buy |
| BVF INC/IL | 1,162,306 | 1,409,993 | +247,687 | 1.14 | 1.31 | +0.16 | buy |
| Avidity Partners Management LP | 1,117,000 | 1,373,000 | +256,000 | 1.67 | 2.22 | +0.55 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,347,252 | +1,347,252 | 0.00 | 0.49 | +0.49 | buy |
| Fiera Capital Corp | 1,335,410 | 1,289,820 | -45,590 | 0.15 | 0.12 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 1,062,123 | 1,062,123 | 0 | 0.48 | 0.35 | -0.13 | hold |
| CITADEL ADVISORS LLC | 1,479,323 | 1,052,381 | -426,942 | 0.05 | 0.03 | -0.02 | sell |
| Soleus Capital Management, L.P. | 694,069 | 1,049,314 | +355,245 | 2.15 | 2.76 | +0.62 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,065,094 | 980,094 | -1,085,000 | 0.13 | 0.05 | -0.08 | sell |
| JENNISON ASSOCIATES LLC | 410,862 | 972,266 | +561,404 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 629,019 | 940,440 | +311,421 | 0.13 | 0.17 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 676,734 | 869,183 | +192,449 | 0.00 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 669,795 | 848,909 | +179,114 | 0.01 | 0.01 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 611,820 | 817,307 | +205,487 | 0.37 | 0.42 | +0.05 | buy |
| NORTHERN TRUST CORP | 640,665 | 771,368 | +130,703 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 481,600 | 706,544 | +224,944 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 610,555 | 689,073 | +78,518 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 759,516 | 681,150 | -78,366 | 1.61 | 1.27 | -0.34 | sell |
| Polar Capital Holdings Plc | 0 | 655,000 | +655,000 | 0.00 | 0.10 | +0.10 | buy |
| Qube Research & Technologies Ltd | 388,252 | 639,609 | +251,357 | 0.03 | 0.04 | +0.01 | buy |
| MACQUARIE GROUP LTD | 258,170 | 638,884 | +380,714 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 483,714 | 611,814 | +128,100 | 0.03 | 0.03 | +0.00 | buy |
| Woodline Partners LP | 456,453 | 588,754 | +132,301 | 0.15 | 0.16 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 884,538 | 567,731 | -316,807 | 0.04 | 0.02 | -0.02 | sell |
| Holocene Advisors, LP | 1,871,873 | 562,848 | -1,309,025 | 0.27 | 0.07 | -0.20 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 422,049 | 531,630 | +109,581 | 3.86 | 4.37 | +0.50 | buy |
| TWO SIGMA INVESTMENTS, LP | 604,548 | 498,590 | -105,958 | 0.05 | 0.04 | -0.01 | sell |
| DAFNA Capital Management LLC | 422,213 | 471,410 | +49,197 | 3.54 | 3.53 | -0.01 | buy |
| TWO SIGMA ADVISERS, LP | 460,400 | 468,100 | +7,700 | 0.04 | 0.03 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 276,798 | 395,488 | +118,690 | 0.11 | 0.13 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,094,872 | 376,353 | -718,519 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 784,125 | 360,637 | -423,488 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 335,772 | 348,774 | +13,002 | 0.01 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 258,606 | 342,081 | +83,475 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 335,000 | 335,000 | 0 | 0.20 | 0.18 | -0.02 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 268,149 | 333,977 | +65,828 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 387,533 | 331,072 | -56,461 | 0.02 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 312,277 | 318,496 | +6,219 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 316,105 | 313,257 | -2,848 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 64,912 | 277,930 | +213,018 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 316,492 | 276,231 | -40,261 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 98,811 | 252,305 | +153,494 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 143,061 | 243,853 | +100,792 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 0 | 232,830 | +232,830 | 0.00 | 0.01 | +0.01 | buy |
| AXA S.A. | 243,484 | 207,980 | -35,504 | 0.03 | 0.02 | -0.01 | sell |
| RTW INVESTMENTS, LP | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 165,776 | 190,293 | +24,517 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 62,732 | 181,170 | +118,438 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 175,000 | +175,000 | 0.00 | 0.27 | +0.27 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 109,325 | 170,365 | +61,040 | 0.01 | 0.01 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 52,047 | 159,466 | +107,419 | 0.04 | 0.10 | +0.06 | buy |
| Invesco Ltd. | 129,924 | 154,602 | +24,678 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 149,224 | 153,612 | +4,388 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 100,502 | 145,804 | +45,302 | 0.01 | 0.02 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 144,717 | 144,717 | 0 | 0.21 | 0.21 | +0.00 | hold |
| Walleye Capital LLC | 13,371 | 141,171 | +127,800 | 0.00 | 0.05 | +0.04 | buy |
| UBS Group AG | 228,805 | 139,547 | -89,258 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 124,700 | 133,100 | +8,400 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 101,787 | 132,703 | +30,916 | 1.05 | 1.26 | +0.21 | buy |
| Rhenman & Partners Asset Management AB | 53,500 | 127,500 | +74,000 | 0.18 | 0.33 | +0.15 | buy |
| Rafferty Asset Management, LLC | 131,096 | 126,019 | -5,077 | 0.02 | 0.01 | -0.00 | sell |
| Sio Capital Management, LLC | 0 | 123,000 | +123,000 | 0.00 | 1.75 | +1.75 | buy |
| Neuberger Berman Group LLC | 90,409 | 120,939 | +30,530 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 105,797 | 112,976 | +7,179 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 104,553 | 108,613 | +4,060 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 104,784 | 98,387 | -6,397 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 79,310 | 97,830 | +18,520 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 0 | 90,000 | +90,000 | 0.00 | 0.20 | +0.20 | buy |
| PRUDENTIAL FINANCIAL INC | 20,550 | 83,935 | +63,385 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 116,690 | 82,090 | -34,600 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 90,482 | 81,979 | -8,503 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 67,751 | 79,780 | +12,029 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 129,013 | 79,537 | -49,476 | 0.00 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 32,370 | 70,763 | +38,393 | 0.18 | 0.27 | +0.08 | buy |
| CITIGROUP INC | 46,077 | 70,682 | +24,605 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 68,346 | 70,070 | +1,724 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 109,137 | 69,867 | -39,270 | 0.08 | 0.05 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,814 | 65,528 | +2,714 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 59,052 | 64,890 | +5,838 | 0.01 | 0.01 | -0.00 | buy |
| Artia Global Partners LP | 54,392 | 62,992 | +8,600 | 0.49 | 0.56 | +0.07 | buy |
| Aquatic Capital Management LLC | 1,900 | 62,000 | +60,100 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,767 | 58,320 | -14,447 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 52,865 | +52,865 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 81,317 | 50,370 | -30,947 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,691 | 50,031 | +11,340 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of New Jersey Common Pension Fund D | 51,792 | 49,839 | -1,953 | 0.01 | 0.01 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 60,050 | 48,604 | -11,446 | 0.06 | 0.04 | -0.02 | sell |
| MetLife Investment Management, LLC | 43,194 | 47,358 | +4,164 | 0.01 | 0.01 | -0.00 | buy |