| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,137,294 | 13,146,545 | +9,251 | 0.02 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 8,842,635 | 8,127,226 | -715,409 | 0.00 | 0.00 | +0.00 | sell |
| Capital Research Global Investors | 6,552,691 | 6,552,691 | 0 | 0.03 | 0.03 | +0.01 | hold |
| JANUS HENDERSON GROUP PLC | 6,206,238 | 6,428,339 | +222,101 | 0.06 | 0.08 | +0.02 | buy |
| VANGUARD GROUP INC | 4,941,945 | 4,922,208 | -19,737 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,627,266 | 4,625,850 | -1,416 | 0.18 | 0.22 | +0.04 | sell |
| Point72 Asset Management, L.P. | 5,028,279 | 3,815,704 | -1,212,575 | 0.25 | 0.23 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 2,118,728 | 3,275,444 | +1,156,716 | 0.43 | 0.64 | +0.21 | buy |
| STATE STREET CORP | 3,385,794 | 3,240,934 | -144,860 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,238,094 | 2,900,094 | +1,662,000 | 0.04 | 0.12 | +0.08 | buy |
| Logos Global Management LP | 3,345,000 | 2,250,000 | -1,095,000 | 9.39 | 6.05 | -3.34 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,915,311 | 2,153,043 | -1,762,268 | 1.49 | 0.90 | -0.60 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,113,164 | 2,150,033 | +36,869 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 1,532,269 | 1,837,967 | +305,698 | 0.11 | 0.16 | +0.05 | buy |
| MORGAN STANLEY | 1,453,377 | 1,580,353 | +126,976 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,825,903 | 1,316,991 | -508,912 | 0.03 | 0.03 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,228,184 | 1,233,113 | +4,929 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,904,916 | 1,109,740 | -795,176 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 751,905 | 1,056,577 | +304,672 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,805,136 | 1,032,999 | -772,137 | 0.04 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 914,400 | 1,012,967 | +98,567 | 0.11 | 0.14 | +0.03 | buy |
| Sofinnova Investments, Inc. | 2,147,795 | 922,695 | -1,225,100 | 3.07 | 1.54 | -1.53 | sell |
| BANK OF AMERICA CORP /DE/ | 923,705 | 916,069 | -7,636 | 0.00 | 0.00 | +0.00 | sell |
| Fisher Asset Management, LLC | 922,092 | 862,208 | -59,884 | 0.01 | 0.01 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 741,833 | 753,164 | +11,331 | 0.03 | 0.03 | +0.01 | buy |
| Redmile Group, LLC | 432,494 | 742,017 | +309,523 | 0.97 | 1.96 | +1.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 716,798 | 715,538 | -1,260 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 715,356 | 709,861 | -5,495 | 0.00 | 0.00 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 771,844 | 625,704 | -146,140 | 0.28 | 0.28 | -0.00 | sell |
| Aberdeen Group plc | 441,305 | 558,048 | +116,743 | 0.02 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 619,090 | 539,923 | -79,167 | 3.59 | 3.63 | +0.04 | sell |
| DIMENSIONAL FUND ADVISORS LP | 170,672 | 497,048 | +326,376 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 401,692 | 488,956 | +87,264 | 0.01 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 377,772 | 409,619 | +31,847 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 701 | 408,452 | +407,751 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 415,399 | 405,645 | -9,754 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 400,000 | +400,000 | 0.00 | 0.42 | +0.42 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 22,117 | 380,311 | +358,194 | 0.00 | 0.02 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 165,885 | 371,825 | +205,940 | 1.12 | 2.04 | +0.92 | buy |
| Rosalind Advisors, Inc. | 511,132 | 350,000 | -161,132 | 5.20 | 3.37 | -1.83 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 109,155 | 299,032 | +189,877 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 260,261 | 280,261 | +20,000 | 0.37 | 0.48 | +0.11 | buy |
| Iron Triangle Partners LP | 0 | 270,000 | +270,000 | 0.00 | 1.04 | +1.04 | buy |
| Qube Research & Technologies Ltd | 525,878 | 263,693 | -262,185 | 0.02 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 321,166 | 250,381 | -70,785 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 249,847 | 248,900 | -947 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 217,134 | 243,008 | +25,874 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 235,425 | +235,425 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 239,738 | 233,412 | -6,326 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 83,288 | 228,889 | +145,601 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 209,551 | 225,733 | +16,182 | 0.03 | 0.04 | +0.01 | buy |
| Nuveen, LLC | 217,320 | 208,759 | -8,561 | 0.00 | 0.00 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 220,952 | 205,765 | -15,187 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 226,390 | 201,667 | -24,723 | 0.03 | 0.03 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 272,660 | 201,443 | -71,217 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 114,644 | 186,722 | +72,078 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 446,420 | 174,265 | -272,155 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 166,917 | 166,917 | 0 | 0.23 | 0.29 | +0.06 | hold |
| SummitTX Capital, L.P. | 207,209 | 164,992 | -42,217 | 0.19 | 0.19 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 163,263 | +163,263 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 14,162 | 158,660 | +144,498 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 150,800 | 152,800 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 66,686 | 137,585 | +70,899 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 121,684 | 132,900 | +11,216 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 131,149 | 124,851 | -6,298 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 124,230 | 124,230 | 0 | 1.05 | 0.86 | -0.19 | hold |
| Invesco Ltd. | 83,982 | 124,196 | +40,214 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 110,300 | +110,300 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 156,639 | 109,712 | -46,927 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 37,389 | 104,666 | +67,277 | 0.00 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 100,000 | +100,000 | 0.00 | 0.65 | +0.65 | buy |
| Soleus Capital Management, L.P. | 250,000 | 100,000 | -150,000 | 0.36 | 0.15 | -0.22 | sell |
| ALLIANCEBERNSTEIN L.P. | 97,830 | 97,889 | +59 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 109,807 | 93,152 | -16,655 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 85,923 | 91,936 | +6,013 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 100,827 | 86,361 | -14,466 | 0.01 | 0.01 | +0.00 | sell |
| MML INVESTORS SERVICES, LLC | 0 | 81,369 | +81,369 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 17,935 | 80,924 | +62,989 | 0.00 | 0.02 | +0.01 | buy |
| ASSETMARK, INC | 62,586 | 76,243 | +13,657 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 50,891 | 74,766 | +23,875 | 0.03 | 0.05 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,532 | 74,573 | -7,959 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 69,694 | 74,269 | +4,575 | 0.02 | 0.02 | -0.00 | buy |
| TEMA ETFS LLC | 69,694 | 74,269 | +4,575 | 0.39 | 0.17 | -0.22 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,184 | 66,493 | -4,691 | 0.00 | 0.00 | +0.00 | sell |
| Fountainhead AM, LLC | 64,901 | 64,901 | 0 | 0.20 | 0.23 | +0.03 | hold |
| Trexquant Investment LP | 0 | 56,275 | +56,275 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 38,720 | 55,363 | +16,643 | 0.01 | 0.02 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 44,625 | 54,432 | +9,807 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 20,117 | 54,137 | +34,020 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 53,715 | +53,715 | 0.00 | 0.04 | +0.04 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cinctive Capital Management LP | 16,993 | 49,946 | +32,953 | 0.02 | 0.07 | +0.05 | buy |
| MetLife Investment Management, LLC | 49,941 | 48,508 | -1,433 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,808 | 46,765 | -18,043 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 34,602 | 45,414 | +10,812 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,945 | 45,324 | -98,621 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 40,450 | 44,880 | +4,430 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 42,283 | +42,283 | 0.00 | 0.04 | +0.04 | buy |
| ALPS ADVISORS INC | 47,243 | 42,150 | -5,093 | 0.01 | 0.01 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 51,284 | 42,077 | -9,207 | 0.00 | 0.00 | -0.00 | sell |