| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,723,160 | 3,551,891 | +1,828,731 | 0.03 | 0.08 | 0.00 | buy |
| Holocene Advisors, LP | 1,032,931 | 1,700,135 | +667,204 | 0.12 | 0.24 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,286,961 | 2,925,094 | +638,133 | 0.14 | 0.22 | +0.08 | buy |
| Capital Research Global Investors | 1,376,870 | 1,976,870 | +600,000 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,030,369 | 3,566,278 | +535,909 | 0.01 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 31,525 | 539,676 | +508,151 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 1,037,187 | 1,458,881 | +421,694 | 1.77 | 2.90 | +1.14 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,268,628 | 2,630,292 | +361,664 | 1.35 | 1.73 | +0.38 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 697,461 | 912,786 | +215,325 | 0.24 | 0.39 | +0.15 | buy |
| Woodline Partners LP | 240,428 | 414,059 | +173,631 | 0.08 | 0.16 | +0.08 | buy |
| Rafferty Asset Management, LLC | 129,076 | 193,356 | +64,280 | 0.02 | 0.03 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 126,149 | 74,575 | +51,574 | 0.09 | 0.19 | 0.00 | sell |
| Hudson Bay Capital Management LP | 35,000 | 84,500 | +49,500 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 113,656 | 137,690 | +24,034 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 87,662 | 108,110 | +20,448 | 0.46 | 0.68 | +0.23 | buy |
| ALGERT GLOBAL LLC | 42,619 | 22,489 | +20,130 | 0.05 | 0.03 | 0.00 | sell |
| DAFNA Capital Management LLC | 499,820 | 516,341 | +16,521 | 4.19 | 4.40 | +0.21 | buy |
| PROFUND ADVISORS LLC | 22,343 | 31,976 | +9,633 | 0.03 | 0.05 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 13,470 | 20,186 | +6,716 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,474 | 7,453 | +5,979 | 0.01 | 0.05 | +0.04 | buy |
| ALPS ADVISORS INC | 42,479 | 42,450 | -29 | 0.01 | 0.01 | +0.00 | sell |
| Redmond Asset Management, LLC | 13,037 | 12,794 | -243 | 0.13 | 0.15 | +0.02 | sell |
| VIRTUS ADVISERS, LLC | 3,977 | 2,705 | -1,272 | 0.07 | 0.06 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 132,701 | 130,265 | -2,436 | 0.66 | 0.66 | -0.00 | sell |
| Nantahala Capital Management, LLC | 145,860 | 139,298 | -6,562 | 0.34 | 0.30 | -0.04 | sell |
| Candriam S.C.A. | 430,019 | 395,019 | -35,000 | 0.08 | 0.10 | +0.01 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 570,682 | 531,967 | -38,715 | 4.86 | 4.42 | -0.44 | sell |
| Sio Capital Management, LLC | 74,007 | 33,007 | -41,000 | 0.62 | 0.27 | -0.35 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 766,682 | 662,343 | -104,339 | 0.81 | 0.96 | +0.15 | sell |
| Cormorant Asset Management, LP | 600,000 | 450,000 | -150,000 | 0.94 | 0.76 | -0.18 | sell |
| Logos Global Management LP | 2,250,000 | 1,800,000 | -450,000 | 8.66 | 7.12 | -1.54 | sell |
| Avidity Partners Management LP | 2,144,971 | 1,520,000 | -624,971 | 2.33 | 2.07 | -0.26 | sell |
| BVF INC/IL | 5,283,489 | 1,729,043 | -3,554,446 | 3.84 | 1.54 | -2.30 | sell |