| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,723,160 | 3,551,891 | +1,828,731 | 0.03 | 0.08 | +0.04 | buy |
| MORGAN STANLEY | 232,776 | 1,233,271 | +1,000,495 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 935,863 | +935,863 | 0.00 | 1.19 | +1.19 | buy |
| CITADEL ADVISORS LLC | 745,100 | 1,643,293 | +898,193 | 0.02 | 0.06 | +0.04 | buy |
| Pictet Asset Management Holding SA | 0 | 875,747 | +875,747 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 2,147,500 | 2,991,899 | +844,399 | 0.00 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 1,032,931 | 1,700,135 | +667,204 | 0.12 | 0.24 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,286,961 | 2,925,094 | +638,133 | 0.14 | 0.22 | +0.08 | buy |
| Capital Research Global Investors | 1,376,870 | 1,976,870 | +600,000 | 0.01 | 0.02 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 564,700 | +564,700 | 0.00 | 2.23 | +2.23 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,030,369 | 3,566,278 | +535,909 | 0.01 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 31,525 | 539,676 | +508,151 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,971,497 | 3,475,772 | +504,275 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,383,729 | 3,883,775 | +500,046 | 0.24 | 0.34 | +0.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 466,271 | +466,271 | 0.00 | 0.05 | +0.05 | buy |
| Sofinnova Investments, Inc. | 1,037,187 | 1,458,881 | +421,694 | 1.94 | 2.91 | +0.96 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,268,628 | 2,630,292 | +361,664 | 1.35 | 1.73 | +0.38 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 346,490 | +346,490 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 0 | 345,674 | +345,674 | 0.00 | 0.99 | +0.99 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 697,461 | 912,786 | +215,325 | 0.24 | 0.39 | +0.15 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,161,105 | 1,351,337 | +190,232 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 240,428 | 414,059 | +173,631 | 0.08 | 0.16 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 52,556 | 207,735 | +155,179 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,142,242 | 1,286,300 | +144,058 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 363,784 | 490,039 | +126,255 | 0.02 | 0.03 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 120,614 | +120,614 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 110,351 | +110,351 | 0.00 | 0.46 | +0.46 | buy |
| Walleye Capital LLC | 89,691 | 199,891 | +110,200 | 0.04 | 0.10 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 85,974 | 189,195 | +103,221 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 56,535 | 150,702 | +94,167 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 436,358 | 529,506 | +93,148 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 86,326 | 176,440 | +90,114 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 83,984 | +83,984 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 71,000 | +71,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 29,909 | 94,368 | +64,459 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 129,076 | 193,356 | +64,280 | 0.02 | 0.03 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 437,356 | 496,456 | +59,100 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 55,239 | +55,239 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 561,368 | 611,009 | +49,641 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 35,000 | 84,500 | +49,500 | 0.01 | 0.03 | +0.02 | buy |
| Qube Research & Technologies Ltd | 35,354 | 77,516 | +42,162 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 55,254 | 89,698 | +34,444 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 31,690 | 61,226 | +29,536 | 0.10 | 0.20 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 113,656 | 137,690 | +24,034 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 17,918 | 41,037 | +23,119 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 87,662 | 108,110 | +20,448 | 0.46 | 0.68 | +0.23 | buy |
| Bank of New York Mellon Corp | 196,289 | 216,667 | +20,378 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,472 | 40,657 | +20,185 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 17,500 | +17,500 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 499,820 | 516,341 | +16,521 | 4.19 | 4.40 | +0.21 | buy |
| Virtu Financial LLC | 0 | 16,369 | +16,369 | 0.00 | 0.05 | +0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,218 | +14,218 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,410 | 92,438 | +14,028 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 12,589 | +12,589 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 0 | 12,494 | +12,494 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 12,372 | 24,578 | +12,206 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,332 | 30,702 | +11,370 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 10,611 | +10,611 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,835 | 18,392 | +10,557 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,385 | +10,385 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 22,343 | 31,976 | +9,633 | 0.03 | 0.05 | +0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 8,269 | +8,269 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 7,440 | +7,440 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 78,794 | 85,966 | +7,172 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,540 | 57,680 | +7,140 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,845 | +6,845 | 0.00 | 0.06 | +0.06 | buy |
| FRED ALGER MANAGEMENT, LLC | 13,470 | 20,186 | +6,716 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 6,045 | +6,045 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,474 | 7,453 | +5,979 | 0.01 | 0.05 | +0.04 | buy |
| Creative Planning | 0 | 5,768 | +5,768 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 16,552 | 21,984 | +5,432 | 0.01 | 0.02 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 30,256 | 35,346 | +5,090 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 4,237 | +4,237 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 112,770 | 116,498 | +3,728 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 270,391 | 274,101 | +3,710 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,816 | 14,081 | +3,265 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,305 | 4,437 | +3,132 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,643 | 31,632 | +2,989 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 27,097 | 29,916 | +2,819 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 25,977 | 27,237 | +1,260 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 3,587 | 4,806 | +1,219 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,395 | 6,230 | +835 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,311 | 18,797 | +486 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,394 | 16,869 | +475 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,138 | 3,431 | +293 | 0.00 | 0.01 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 189 | 469 | +280 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 14,415 | 14,627 | +212 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 254 | 368 | +114 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 7,205 | 7,294 | +89 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 62 | 142 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 193 | 264 | +71 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,613 | 15,633 | +20 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 164 | 183 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 5 | 21 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 6 | 12 | +6 | 0.00 | 0.00 | 0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,030 | 5,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,062,123 | 1,062,123 | 0 | 0.17 | 0.43 | +0.26 | hold |
| HighVista Strategies LLC | 126,845 | 126,845 | 0 | 1.58 | 1.64 | +0.05 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 335,000 | 335,000 | 0 | 0.16 | 0.19 | +0.03 | hold |