| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 2,100,000 | 3,000,000 | +900,000 | 7.18 | 9.02 | +1.84 | buy |
| JANUS HENDERSON GROUP PLC | 5,162,376 | 5,857,639 | +695,263 | 0.08 | 0.08 | 0.00 | buy |
| Candriam S.C.A. | 629,019 | 1,071,825 | +442,806 | 0.13 | 0.16 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 335,000 | 771,844 | +436,844 | 0.18 | 0.36 | +0.18 | buy |
| ExodusPoint Capital Management, LP | 395,488 | 52,252 | +343,236 | 0.13 | 0.01 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 980,094 | 1,200,094 | +220,000 | 0.05 | 0.05 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,594,000 | 2,736,000 | +142,000 | 1.23 | 1.33 | +0.10 | buy |
| Qube Research & Technologies Ltd | 639,609 | 759,883 | +120,274 | 0.04 | 0.03 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 498,590 | 423,774 | +74,816 | 0.04 | 0.03 | 0.00 | sell |
| Aberdeen Group plc | 232,830 | 306,723 | +73,893 | 0.01 | 0.01 | +0.00 | buy |
| Crestline Management, LP | 24,857 | 95,428 | +70,571 | 0.04 | 0.08 | +0.04 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 90,000 | 120,261 | +30,261 | 0.20 | 0.22 | +0.02 | buy |
| Brevan Howard Capital Management LP | 14,326 | 44,539 | +30,213 | 0.00 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 34,413 | 63,672 | +29,259 | 0.10 | 0.13 | +0.03 | buy |
| Fisher Asset Management, LLC | 848,909 | 876,599 | +27,690 | 0.01 | 0.01 | -0.00 | buy |
| DAFNA Capital Management LLC | 471,410 | 498,827 | +27,417 | 3.53 | 3.26 | -0.27 | buy |
| AlphaQuest LLC | 34,062 | 7,661 | +26,401 | 0.10 | 0.03 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 48,604 | 72,716 | +24,112 | 0.12 | 0.15 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 243,853 | 229,316 | +14,537 | 0.01 | 0.01 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 144,717 | 152,713 | +7,996 | 0.21 | 0.23 | +0.02 | buy |
| Palumbo Wealth Management LLC | 7,047 | 13,509 | +6,462 | 0.09 | 0.13 | +0.04 | buy |
| ALPS ADVISORS INC | 64,890 | 69,892 | +5,002 | 0.01 | 0.01 | -0.00 | buy |
| Nebula Research & Development LLC | 70,763 | 75,417 | +4,654 | 0.27 | 0.23 | -0.04 | buy |
| JENNISON ASSOCIATES LLC | 972,266 | 974,636 | +2,370 | 0.02 | 0.02 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,249 | 18,327 | +2,078 | 0.06 | 0.04 | -0.01 | buy |
| PROFUND ADVISORS LLC | 25,574 | 23,601 | +1,973 | 0.03 | 0.02 | 0.00 | sell |
| Woodline Partners LP | 588,754 | 590,697 | +1,943 | 0.16 | 0.10 | -0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 15,063 | 16,913 | +1,850 | 0.04 | 0.04 | 0.00 | buy |
| NEOS Investment Management LLC | 14,489 | 16,066 | +1,577 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,369 | 2,758 | +389 | 0.04 | 0.03 | -0.01 | buy |
| E Fund Management Co., Ltd. | 8,097 | 8,364 | +267 | 0.01 | 0.01 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 124 | 179 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Capital Research Global Investors | 2,566,356 | 2,565,897 | -459 | 0.02 | 0.01 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 531,630 | 524,868 | -6,762 | 4.37 | 4.55 | +0.18 | sell |
| Rafferty Asset Management, LLC | 126,019 | 118,227 | -7,792 | 0.01 | 0.01 | -0.00 | sell |
| SAMLYN CAPITAL, LLC | 817,307 | 792,399 | -24,908 | 0.39 | 0.31 | -0.08 | sell |
| Rhenman & Partners Asset Management AB | 127,500 | 82,000 | -45,500 | 0.33 | 0.22 | -0.11 | sell |
| Redmile Group, LLC | 681,150 | 619,300 | -61,850 | 1.27 | 1.11 | -0.16 | sell |
| TWINBEECH CAPITAL LP | 159,466 | 87,802 | -71,664 | 0.10 | 0.04 | -0.06 | sell |
| Fiera Capital Corp | 1,289,820 | 1,184,467 | -105,353 | 0.12 | 0.10 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,015,298 | 3,866,908 | -148,390 | 0.01 | 0.01 | -0.00 | sell |
| Avidity Partners Management LP | 1,373,000 | 1,126,700 | -246,300 | 2.22 | 2.84 | +0.63 | sell |
| Polar Capital Holdings Plc | 655,000 | 65,500 | -589,500 | 0.10 | 0.01 | -0.09 | sell |
| Sofinnova Investments, Inc. | 1,749,455 | 1,069,090 | -680,365 | 4.40 | 2.00 | -2.40 | sell |