| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 360,637 | 1,555,080 | +1,194,443 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 2,100,000 | 3,000,000 | +900,000 | 7.45 | 9.02 | +1.57 | buy |
| GOLDMAN SACHS GROUP INC | 869,183 | 1,758,133 | +888,950 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,052,381 | 1,836,830 | +784,449 | 0.03 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 7,680,941 | 8,377,056 | +696,115 | 0.01 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 5,162,376 | 5,857,639 | +695,263 | 0.08 | 0.08 | -0.01 | buy |
| NORGES BANK | 0 | 520,810 | +520,810 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 335,000 | 771,844 | +436,844 | 0.18 | 0.36 | +0.18 | buy |
| MPM BioImpact LLC | 0 | 414,035 | +414,035 | 0.00 | 1.51 | +1.51 | buy |
| FMR LLC | 12,635,653 | 12,963,151 | +327,498 | 0.02 | 0.02 | -0.00 | buy |
| VANGUARD GROUP INC | 4,795,148 | 5,078,084 | +282,936 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 139,547 | 418,485 | +278,938 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 241,894 | +241,894 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 227,102 | +227,102 | 0.00 | 5.13 | +5.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 980,094 | 1,200,094 | +220,000 | 0.05 | 0.05 | -0.00 | buy |
| JPMORGAN CHASE & CO | 79,780 | 274,693 | +194,913 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,594,000 | 2,736,000 | +142,000 | 1.23 | 1.34 | +0.11 | buy |
| Candriam S.C.A. | 940,440 | 1,071,825 | +131,385 | 0.17 | 0.16 | -0.01 | buy |
| Neo Ivy Capital Management | 0 | 130,806 | +130,806 | 0.00 | 0.68 | +0.68 | buy |
| Qube Research & Technologies Ltd | 639,609 | 759,883 | +120,274 | 0.04 | 0.03 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 170,365 | 284,267 | +113,902 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 107,147 | +107,147 | 0.00 | 0.03 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 190,293 | 286,759 | +96,466 | 0.02 | 0.03 | +0.00 | buy |
| Aberdeen Group plc | 232,830 | 306,723 | +73,893 | 0.01 | 0.01 | +0.00 | buy |
| Crestline Management, LP | 24,857 | 95,428 | +70,571 | 0.04 | 0.09 | +0.04 | buy |
| Fountainhead AM, LLC | 0 | 64,556 | +64,556 | 0.00 | 0.30 | +0.30 | buy |
| MARSHALL WACE, LLP | 252,305 | 312,666 | +60,361 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 70,682 | 126,164 | +55,482 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 7,771 | 56,108 | +48,337 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 47,728 | +47,728 | 0.00 | 0.46 | +0.46 | buy |
| Pictet Asset Management Holding SA | 1,894,340 | 1,941,271 | +46,931 | 0.07 | 0.05 | -0.01 | buy |
| Jump Financial, LLC | 69,867 | 114,902 | +45,035 | 0.05 | 0.06 | +0.02 | buy |
| Neuberger Berman Group LLC | 120,939 | 165,527 | +44,588 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,945,455 | 1,988,681 | +43,226 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 207,980 | 249,702 | +41,722 | 0.02 | 0.02 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 706,544 | 747,934 | +41,390 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 145,804 | 178,892 | +33,088 | 0.02 | 0.01 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 31,389 | +31,389 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 49,839 | 81,174 | +31,335 | 0.01 | 0.01 | +0.00 | buy |
| GENERAL AMERICAN INVESTORS CO INC | 90,000 | 120,261 | +30,261 | 0.20 | 0.22 | +0.02 | buy |
| Brevan Howard Capital Management LP | 14,326 | 44,539 | +30,213 | 0.02 | 0.03 | +0.01 | buy |
| BIT Capital GmbH | 34,413 | 63,672 | +29,259 | 0.10 | 0.14 | +0.04 | buy |
| Aquatic Capital Management LLC | 62,000 | 91,189 | +29,189 | 0.05 | 0.06 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 313,257 | 341,063 | +27,806 | 0.01 | 0.01 | -0.00 | buy |
| Fisher Asset Management, LLC | 848,909 | 876,599 | +27,690 | 0.01 | 0.01 | -0.00 | buy |
| DAFNA Capital Management LLC | 471,410 | 498,827 | +27,417 | 3.53 | 3.26 | -0.27 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 27,276 | +27,276 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 348,774 | 372,979 | +24,205 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 48,604 | 72,716 | +24,112 | 0.04 | 0.05 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 689,073 | 712,811 | +23,738 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 33,414 | 56,188 | +22,774 | 0.02 | 0.03 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 83,935 | 101,935 | +18,000 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 181,170 | 198,756 | +17,586 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 133,100 | 149,600 | +16,500 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,056 | 50,627 | +15,571 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 23,225 | 38,690 | +15,465 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 3,397 | 18,486 | +15,089 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,390 | 19,242 | +14,852 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 0 | 14,670 | +14,670 | 0.00 | 0.16 | +0.16 | buy |
| Legal & General Group Plc | 70,070 | 82,442 | +12,372 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 81,979 | 94,138 | +12,159 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 10,899 | +10,899 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 28,149 | 38,692 | +10,543 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 277,930 | 288,002 | +10,072 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 8,677 | 18,399 | +9,722 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 144,717 | 152,713 | +7,996 | 0.21 | 0.23 | +0.02 | buy |
| CIBC WORLD MARKETS CORP | 0 | 7,904 | +7,904 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,920 | 36,232 | +7,312 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 21,130 | 27,882 | +6,752 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 7,047 | 13,509 | +6,462 | 0.09 | 0.13 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,528 | 71,726 | +6,198 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,085 | 22,536 | +5,451 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 64,890 | 69,892 | +5,002 | 0.01 | 0.01 | -0.00 | buy |
| XTX Topco Ltd | 7,719 | 12,679 | +4,960 | 0.02 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 318,496 | 323,286 | +4,790 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 70,763 | 75,417 | +4,654 | 0.27 | 0.23 | -0.04 | buy |
| MetLife Investment Management, LLC | 47,358 | 50,615 | +3,257 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 3,317,936 | 3,320,898 | +2,962 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,031 | 52,736 | +2,705 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 19,613 | 22,049 | +2,436 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 972,266 | 974,636 | +2,370 | 0.02 | 0.02 | -0.00 | buy |
| MAI Capital Management | 0 | 2,250 | +2,250 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,249 | 18,327 | +2,078 | 0.06 | 0.04 | -0.01 | buy |
| Woodline Partners LP | 588,754 | 590,697 | +1,943 | 0.16 | 0.10 | -0.05 | buy |
| KBC Group NV | 2,274 | 4,197 | +1,923 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 23,400 | 25,300 | +1,900 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 15,063 | 16,913 | +1,850 | 0.04 | 0.03 | -0.00 | buy |
| NEOS Investment Management LLC | 14,489 | 16,066 | +1,577 | 0.01 | 0.01 | -0.00 | buy |
| ASSETMARK, INC | 44,185 | 45,269 | +1,084 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 8,906 | 9,775 | +869 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 1,939 | 2,792 | +853 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12 | 708 | +696 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 112,976 | 113,561 | +585 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 771,368 | 771,852 | +484 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 402 | 858 | +456 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,369 | 2,758 | +389 | 0.04 | 0.03 | -0.01 | buy |
| Covestor Ltd | 926 | 1,222 | +296 | 0.02 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 8,097 | 8,364 | +267 | 0.01 | 0.01 | -0.00 | buy |
| GROUP ONE TRADING LLC | 8 | 271 | +263 | 0.00 | 0.00 | +0.00 | buy |