| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,146,545 | 13,149,960 | +3,415 | 0.02 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 8,127,226 | 8,209,392 | +82,166 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 6,428,339 | 7,186,456 | +758,117 | 0.08 | 0.11 | +0.03 | buy |
| Capital Research Global Investors | 6,552,691 | 5,279,675 | -1,273,016 | 0.03 | 0.03 | +0.00 | sell |
| VANGUARD GROUP INC | 4,922,208 | 5,019,324 | +97,116 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,240,934 | 4,134,641 | +893,707 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,275,444 | 3,618,826 | +343,382 | 0.64 | 0.73 | +0.09 | buy |
| FEDERATED HERMES, INC. | 4,625,850 | 3,395,771 | -1,230,079 | 0.22 | 0.20 | -0.03 | sell |
| Logos Global Management LP | 2,250,000 | 3,125,000 | +875,000 | 6.05 | 7.20 | +1.15 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,900,094 | 2,800,000 | -100,094 | 0.12 | 0.15 | +0.02 | sell |
| Fiera Capital Corp | 1,837,967 | 2,437,262 | +599,295 | 0.16 | 0.27 | +0.11 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,153,043 | 2,153,043 | 0 | 0.90 | 0.95 | +0.06 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,150,033 | 2,073,583 | -76,450 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 3,815,704 | 1,844,556 | -1,971,148 | 0.23 | 0.10 | -0.13 | sell |
| GOLDMAN SACHS GROUP INC | 1,233,113 | 1,770,866 | +537,753 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,109,740 | 1,449,145 | +339,405 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,580,353 | 1,252,404 | -327,949 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 1,056,577 | 1,085,632 | +29,055 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 1,012,967 | 1,031,354 | +18,387 | 0.14 | 0.18 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 753,164 | 979,063 | +225,899 | 0.03 | 0.06 | +0.03 | buy |
| CITADEL ADVISORS LLC | 1,316,991 | 959,355 | -357,636 | 0.03 | 0.02 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 497,048 | 938,857 | +441,809 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 916,069 | 902,973 | -13,096 | 0.00 | 0.00 | +0.00 | sell |
| Fisher Asset Management, LLC | 862,208 | 889,633 | +27,425 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 922,695 | 885,121 | -37,574 | 1.54 | 1.32 | -0.22 | sell |
| Redmile Group, LLC | 742,017 | 742,017 | 0 | 1.96 | 1.89 | -0.08 | hold |
| Pictet Asset Management Holding SA | 1,032,999 | 734,335 | -298,664 | 0.03 | 0.02 | -0.00 | sell |
| First Turn Management, LLC | 0 | 723,653 | +723,653 | 0.00 | 2.86 | +2.86 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,538 | 714,633 | -905 | 0.00 | 0.00 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 408,452 | 697,925 | +289,473 | 0.03 | 0.03 | -0.00 | buy |
| NORTHERN TRUST CORP | 709,861 | 675,123 | -34,738 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 380,311 | 596,483 | +216,172 | 0.02 | 0.04 | +0.02 | buy |
| Aberdeen Group plc | 558,048 | 560,623 | +2,575 | 0.02 | 0.03 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 488,956 | 508,347 | +19,391 | 0.02 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 539,923 | 506,740 | -33,183 | 3.63 | 4.07 | +0.44 | sell |
| Qube Research & Technologies Ltd | 263,693 | 467,851 | +204,158 | 0.01 | 0.02 | +0.01 | buy |
| Iron Triangle Partners LP | 270,000 | 467,484 | +197,484 | 1.04 | 1.85 | +0.80 | buy |
| TANG CAPITAL MANAGEMENT LLC | 400,000 | 450,000 | +50,000 | 0.42 | 0.77 | +0.35 | buy |
| Nuveen, LLC | 208,759 | 374,007 | +165,248 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 405,645 | 368,481 | -37,164 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 174,265 | 299,888 | +125,623 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 625,704 | 284,069 | -341,635 | 0.28 | 0.15 | -0.13 | sell |
| GENERAL AMERICAN INVESTORS CO INC | 280,261 | 280,261 | 0 | 0.48 | 0.60 | +0.13 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 299,032 | 277,560 | -21,472 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 243,008 | 256,144 | +13,136 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 250,000 | +250,000 | 0.00 | 0.81 | +0.81 | buy |
| Bank of New York Mellon Corp | 248,900 | 244,041 | -4,859 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 235,425 | 240,209 | +4,784 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 124,196 | 238,314 | +114,118 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 250,381 | 235,872 | -14,509 | 0.00 | 0.00 | +0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 233,412 | 219,268 | -14,144 | 0.01 | 0.02 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 137,585 | 208,548 | +70,963 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 186,722 | 204,398 | +17,676 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 163,263 | 202,434 | +39,171 | 0.07 | 0.11 | +0.04 | buy |
| Woodline Partners LP | 201,667 | 201,667 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Nicholas Investment Partners, LP | 0 | 192,413 | +192,413 | 0.00 | 0.48 | +0.48 | buy |
| Alyeska Investment Group, L.P. | 0 | 192,308 | +192,308 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 201,443 | 174,124 | -27,319 | 0.00 | 0.00 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205,765 | 171,278 | -34,487 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 409,619 | 165,323 | -244,296 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 228,889 | 163,407 | -65,482 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 371,825 | 161,659 | -210,166 | 2.04 | 0.96 | -1.08 | sell |
| Swiss National Bank | 152,800 | 155,600 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 149,993 | +149,993 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 132,900 | 136,055 | +3,155 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 40,807 | 127,067 | +86,260 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 93,152 | 126,362 | +33,210 | 0.01 | 0.02 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 166,917 | 120,604 | -46,313 | 0.29 | 0.96 | +0.67 | sell |
| TWO SIGMA INVESTMENTS, LP | 109,712 | 113,841 | +4,129 | 0.00 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 111,276 | +111,276 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 124,851 | 107,625 | -17,226 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 97,889 | 97,886 | -3 | 0.00 | 0.00 | +0.00 | sell |
| Atle Fund Management AB | 0 | 97,438 | +97,438 | 0.00 | 1.07 | +1.07 | buy |
| MML INVESTORS SERVICES, LLC | 81,369 | 83,939 | +2,570 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 91,936 | 83,865 | -8,071 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 81,033 | +81,033 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,573 | 75,945 | +1,372 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 124,230 | 75,730 | -48,500 | 0.86 | 0.43 | -0.42 | sell |
| ASSETMARK, INC | 76,243 | 71,937 | -4,306 | 0.00 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 42,150 | 71,789 | +29,639 | 0.01 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 74,269 | 71,178 | -3,091 | 0.02 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 74,269 | 70,128 | -4,141 | 0.17 | 0.19 | +0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 66,493 | 69,909 | +3,416 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 45,414 | 68,707 | +23,293 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 22,226 | 68,177 | +45,951 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 66,175 | +66,175 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,324 | 63,558 | +18,234 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 74,766 | 60,258 | -14,508 | 0.05 | 0.05 | +0.00 | sell |
| Orion Porfolio Solutions, LLC | 54,432 | 58,394 | +3,962 | 0.01 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 19,500 | 57,167 | +37,667 | 0.03 | 0.09 | +0.06 | buy |
| Lido Advisors, LLC | 0 | 55,465 | +55,465 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 48,920 | +48,920 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 37,595 | 47,938 | +10,343 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 20,691 | 47,115 | +26,424 | 0.02 | 0.05 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 26,440 | 46,040 | +19,600 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 49,946 | 45,965 | -3,981 | 0.07 | 0.09 | +0.02 | sell |
| MetLife Investment Management, LLC | 48,508 | 45,813 | -2,695 | 0.01 | 0.01 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 44,880 | 44,954 | +74 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,077 | 44,683 | +2,606 | 0.00 | 0.00 | +0.00 | buy |