| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 2,250,000 | 3,125,000 | +875,000 | 6.05 | 7.20 | +1.15 | buy |
| Fiera Capital Corp | 1,837,967 | 2,437,262 | +599,295 | 0.16 | 0.27 | +0.11 | buy |
| BAKER BROS. ADVISORS LP | 3,275,444 | 3,618,826 | +343,382 | 0.64 | 0.73 | +0.09 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,109,740 | 1,449,145 | +339,405 | 0.00 | 0.01 | +0.00 | buy |
| Iron Triangle Partners LP | 270,000 | 467,484 | +197,484 | 1.04 | 1.85 | +0.80 | buy |
| TANG CAPITAL MANAGEMENT LLC | 400,000 | 450,000 | +50,000 | 0.42 | 0.77 | +0.35 | buy |
| Susquehanna Portfolio Strategies, LLC | 163,263 | 202,434 | +39,171 | 0.07 | 0.11 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205,765 | 171,278 | +34,487 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 93,152 | 126,362 | +33,210 | 0.01 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 42,150 | 71,789 | +29,639 | 0.01 | 0.01 | 0.00 | buy |
| PROFUND ADVISORS LLC | 20,691 | 47,115 | +26,424 | 0.02 | 0.05 | 0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 488,956 | 508,347 | +19,391 | 0.02 | 0.02 | +0.01 | buy |
| WESBANCO BANK INC | 21,200 | 39,700 | +18,500 | 0.02 | 0.04 | +0.02 | buy |
| Candriam S.C.A. | 1,012,967 | 1,031,354 | +18,387 | 0.14 | 0.18 | +0.03 | buy |
| BIT Capital GmbH | 3,019 | 16,900 | +13,881 | 0.00 | 0.02 | +0.02 | buy |
| Palumbo Wealth Management LLC | 17,452 | 28,024 | +10,572 | 0.15 | 0.24 | +0.09 | buy |
| Virtus Investment Advisers, LLC | 5,107 | 7,819 | +2,712 | 0.04 | 0.07 | +0.03 | buy |
| Aberdeen Group plc | 558,048 | 560,623 | +2,575 | 0.02 | 0.03 | +0.01 | buy |
| AlphaQuest LLC | 41,028 | 38,767 | +2,261 | 0.08 | 0.08 | 0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 16,306 | 15,729 | +577 | 0.00 | 0.01 | 0.00 | sell |
| ANTIPODES PARTNERS Ltd | 770 | 1,150 | +380 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,886 | 1,722 | -164 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 15,363 | 14,285 | -1,078 | 0.03 | 0.04 | +0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 34,337 | 33,199 | -1,138 | 0.05 | 0.07 | +0.01 | sell |
| NEOS Investment Management LLC | 74,269 | 71,178 | -3,091 | 0.02 | 0.01 | -0.00 | sell |
| Cinctive Capital Management LP | 49,946 | 45,965 | -3,981 | 0.07 | 0.09 | +0.02 | sell |
| TEMA ETFS LLC | 74,269 | 70,128 | -4,141 | 0.17 | 0.19 | +0.02 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 233,412 | 219,268 | -14,144 | 0.01 | 0.02 | +0.00 | sell |
| FIFTH LANE CAPITAL, LP | 34,237 | 12,500 | -21,737 | 0.94 | 0.51 | -0.43 | sell |
| DAFNA Capital Management LLC | 539,923 | 506,740 | -33,183 | 3.63 | 4.07 | +0.44 | sell |
| Sofinnova Investments, Inc. | 922,695 | 885,121 | -37,574 | 1.37 | 1.32 | -0.05 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 166,917 | 120,604 | -46,313 | 0.29 | 0.96 | +0.67 | sell |
| Sio Capital Management, LLC | 124,230 | 75,730 | -48,500 | 0.86 | 0.41 | -0.44 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,900,094 | 2,800,000 | -100,094 | 0.12 | 0.15 | +0.02 | sell |
| STEMPOINT CAPITAL LP | 371,825 | 161,659 | -210,166 | 2.04 | 0.96 | -1.08 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 625,704 | 284,069 | -341,635 | 0.28 | 0.15 | -0.13 | sell |
| Capital Research Global Investors | 6,552,691 | 5,279,675 | -1,273,016 | 0.03 | 0.03 | +0.00 | sell |