| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 947,049 | +947,049 | 0.00 | 0.14 | +0.14 | buy |
| Kynam Capital Management, LP | 788,867 | 1,592,551 | +803,684 | 0.15 | 0.35 | +0.20 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 122,752 | 558,339 | +435,587 | 0.07 | 0.33 | +0.25 | buy |
| MILLENNIUM MANAGEMENT LLC | 150,997 | 382,737 | +231,740 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 152,825 | +152,825 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 788,695 | 923,626 | +134,931 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 135,909 | 267,788 | +131,879 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 124,378 | +124,378 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 117,477 | 236,469 | +118,992 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 273,883 | 358,906 | +85,023 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 111,040 | 192,963 | +81,923 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 46,090 | 109,085 | +62,995 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 58,699 | +58,699 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 266,280 | 321,886 | +55,606 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 35,210 | +35,210 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 272,886 | 302,458 | +29,572 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 11,980 | +11,980 | 0.00 | 0.01 | +0.01 | buy |
| NINE MASTS CAPITAL Ltd | 0 | 11,699 | +11,699 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 11,343 | +11,343 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 127,292 | 138,231 | +10,939 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 10,294 | +10,294 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 50,159 | 57,190 | +7,031 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 271,300 | 275,200 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 500 | 3,907 | +3,407 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,520 | 17,420 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 230 | +230 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 10,909,256 | 10,909,256 | 0 | 0.65 | 0.81 | +0.17 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,500 | 53,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 95 | 95 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,123,824 | 10,123,824 | 0 | 0.17 | 0.20 | +0.03 | hold |
| Focus Partners Wealth | 50,007 | 50,007 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 50,120 | 50,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 13,652 | 13,652 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,634 | 1,634 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 8,602 | 8,600 | -2 | 0.00 | 0.00 | +0.00 | sell |
| Cerity Partners LLC | 32,953 | 32,875 | -78 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 2,741 | 2,641 | -100 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 6,152 | 6,009 | -143 | 0.00 | 0.00 | +0.00 | sell |
| CALDWELL SUTTER CAPITAL, INC. | 2,000 | 1,000 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 21,551 | 16,417 | -5,134 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 535,703 | 511,519 | -24,184 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 73,000 | 32,700 | -40,300 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 59,168 | 16,329 | -42,839 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,546 | 0 | -70,546 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 160,652 | 0 | -160,652 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 237,300 | 0 | -237,300 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 755,956 | 0 | -755,956 | 0.00 | 0.00 | -0.00 | sell |