| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 6,475,882 | +6,475,882 | 0.00 | 0.30 | +0.30 | buy |
| Soleus Capital Management, L.P. | 0 | 3,378,378 | +3,378,378 | 0.00 | 0.62 | +0.62 | buy |
| ORBIMED ADVISORS LLC | 10,909,256 | 13,724,571 | +2,815,315 | 0.81 | 1.39 | +0.57 | buy |
| BlackRock, Inc. | 321,886 | 1,797,501 | +1,475,615 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 1,592,551 | 2,415,087 | +822,536 | 0.35 | 0.71 | +0.37 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 766,095 | +766,095 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 152,825 | 900,900 | +748,075 | 0.03 | 0.23 | +0.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 302,458 | 841,862 | +539,404 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 503,860 | +503,860 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 382,737 | 844,993 | +462,256 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 558,339 | 1,019,832 | +461,493 | 0.33 | 0.78 | +0.45 | buy |
| UBS Group AG | 0 | 318,797 | +318,797 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 138,231 | 428,787 | +290,556 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 50,120 | 240,599 | +190,479 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 511,519 | 611,359 | +99,840 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 81,400 | +81,400 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 923,626 | 993,369 | +69,743 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 68,187 | +68,187 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 67,622 | +67,622 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 67,622 | +67,622 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 59,540 | +59,540 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 47,574 | +47,574 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 45,261 | +45,261 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 37,023 | +37,023 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 34,742 | +34,742 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 32,862 | +32,862 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 0 | 27,824 | +27,824 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 25,325 | +25,325 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 22,758 | +22,758 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 22,074 | +22,074 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 11,343 | 29,770 | +18,427 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 109,085 | 125,606 | +16,521 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 15,475 | +15,475 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 13,352 | +13,352 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5 | 13,033 | +13,028 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 12,784 | +12,784 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,672 | +12,672 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,500 | 64,500 | +11,000 | 0.00 | 0.01 | +0.00 | buy |
| Spark Investment Management LLC | 0 | 10,600 | +10,600 | 0.00 | 0.11 | +0.11 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 10,530 | +10,530 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 10,492 | +10,492 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,430 | +6,430 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 275,200 | 281,200 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,600 | 14,529 | +5,929 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 95 | 4,104 | +4,009 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,699 | +2,699 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,520 | +2,520 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,377 | +2,377 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 755 | +755 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 97 | +97 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,123,824 | 10,123,824 | 0 | 0.20 | 0.27 | +0.07 | hold |
| Cerity Partners LLC | 32,875 | 32,875 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 230 | 230 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 35,210 | 35,210 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 13,652 | 13,652 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 3,907 | 3,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,634 | 1,634 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 20 | 4 | -16 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 6,009 | 5,629 | -380 | 0.00 | 0.00 | +0.00 | sell |
| CALDWELL SUTTER CAPITAL, INC. | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 2,641 | 22 | -2,619 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 16,417 | 13,110 | -3,307 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 10,294 | 0 | -10,294 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 11,699 | 0 | -11,699 | 0.01 | 0.00 | -0.01 | sell |
| Diametric Capital, LP | 11,980 | 0 | -11,980 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 16,329 | 0 | -16,329 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 17,420 | 0 | -17,420 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 32,700 | 0 | -32,700 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 50,007 | 0 | -50,007 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 57,190 | 0 | -57,190 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 58,699 | 0 | -58,699 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 236,469 | 120,834 | -115,635 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 124,378 | 0 | -124,378 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 358,906 | 190,692 | -168,214 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 192,963 | 0 | -192,963 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,788 | 0 | -267,788 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 947,049 | 0 | -947,049 | 0.14 | 0.00 | -0.14 | sell |