| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ExodusPoint Capital Management, LP | 0 | 921,621 | +921,621 | 0.00 | 0.02 | +0.02 | buy |
| Avidity Partners Management LP | 0 | 890,000 | +890,000 | 0.00 | 0.09 | +0.09 | buy |
| MARSHALL WACE, LLP | 0 | 359,137 | +359,137 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 281,583 | +281,583 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 891,298 | 1,097,599 | +206,301 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 160,524 | +160,524 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 17,761 | 174,979 | +157,218 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 211,746 | 286,046 | +74,300 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 15,229 | 83,175 | +67,946 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 123,600 | 176,100 | +52,500 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 22,110 | 74,143 | +52,033 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 48,239 | +48,239 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 40,102 | +40,102 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 32,875 | +32,875 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 361,951 | 391,716 | +29,765 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 522,375 | 549,530 | +27,155 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 74,923 | 95,161 | +20,238 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 20,048 | +20,048 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 48,727 | 64,409 | +15,682 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 15,534 | +15,534 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 43,135 | 56,933 | +13,798 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 14,601 | 27,165 | +12,564 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 11,295 | +11,295 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,010,565 | 1,021,770 | +11,205 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 9,332 | +9,332 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,014 | 9,655 | +6,641 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 128,033 | 133,249 | +5,216 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 5,206 | +5,206 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 12,345 | 17,293 | +4,948 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 29,074 | 29,082 | +8 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 10,909,256 | 10,909,256 | 0 | 0.83 | 0.41 | -0.41 | hold |
| Ameritas Investment Partners, Inc. | 819 | 819 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 160,652 | 160,652 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 955 | 955 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,123,824 | 10,123,824 | 0 | 0.49 | 0.22 | -0.28 | hold |
| Arax Advisory Partners | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 962 | 962 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 334 | 334 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,045 | 70,045 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 14,618 | 14,618 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 22 | 10 | -12 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 7,092 | 7,049 | -43 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,135 | 7,271 | -864 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,481 | 76 | -1,405 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,064 | 5,302 | -1,762 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 9,575 | 7,618 | -1,957 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 50,900 | 47,900 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 3,126 | 0 | -3,126 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 24,905 | 20,772 | -4,133 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 36,276 | 28,613 | -7,663 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 21,565 | 12,004 | -9,561 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 206,600 | 196,900 | -9,700 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 11,074 | 0 | -11,074 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,122 | 3,622 | -15,500 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 124,686 | 106,377 | -18,309 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 18,700 | 0 | -18,700 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 18,839 | 0 | -18,839 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 31,388 | 0 | -31,388 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,283 | 0 | -35,283 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 287,354 | 0 | -287,354 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 320,394 | 0 | -320,394 | 0.46 | 0.00 | -0.46 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,133,000 | 3,766,120 | -366,880 | 0.26 | 0.12 | -0.15 | sell |