| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 4,133,000 | +4,133,000 | 0.00 | 0.33 | +0.33 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 36,949 | 148,749 | +111,800 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 139,374 | 216,400 | +77,026 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 244,470 | 298,796 | +54,326 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 12,813 | 58,284 | +45,471 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 973,606 | 1,006,856 | +33,250 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 63,867 | 96,966 | +33,099 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 30,781 | 63,581 | +32,800 | 0.01 | 0.04 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 31,100 | 61,800 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 187,209 | 212,234 | +25,025 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 331,100 | 349,367 | +18,267 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 32,882 | 50,600 | +17,718 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,316 | 30,526 | +17,210 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 15,130 | +15,130 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 14,346 | +14,346 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 13,607 | +13,607 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,100 | +13,100 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 32,907 | 44,087 | +11,180 | 0.00 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 7,023 | 15,495 | +8,472 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,188 | 14,305 | +3,117 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 67,688 | 69,465 | +1,777 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,031 | 124,700 | +1,669 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 526 | 2,127 | +1,601 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,500 | 3,992 | +492 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 510,279 | 510,749 | +470 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 7,102 | 7,397 | +295 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 31 | 67 | +36 | 0.00 | 0.00 | 0.00 | buy |
| HSBC HOLDINGS PLC | 23,198 | 23,210 | +12 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 10,909,256 | 10,909,256 | 0 | 0.72 | 0.93 | +0.21 | hold |
| Ameritas Investment Partners, Inc. | 819 | 819 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 160,652 | 160,652 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,123,824 | 10,123,824 | 0 | 0.18 | 0.49 | +0.31 | hold |
| HighMark Wealth Management LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 962 | 962 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,165 | 70,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,149 | 20,122 | -27 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 37 | 0 | -37 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 964 | 864 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 104 | 0 | -104 | 0.00 | 0.00 | 0.00 | sell |
| DEUTSCHE BANK AG\ | 446 | 0 | -446 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,140 | 2,449 | -691 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,076 | 0 | -1,076 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 115,518 | 114,097 | -1,421 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 6,107 | 0 | -6,107 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 143,957 | 131,307 | -12,650 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 33,815 | 20,403 | -13,412 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,066,858 | 1,042,737 | -24,121 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 350,000 | 320,394 | -29,606 | 0.33 | 0.35 | +0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,600 | 24,800 | -36,800 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 49,184 | 0 | -49,184 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 88,802 | 29,418 | -59,384 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 70,583 | 0 | -70,583 | 0.02 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 200,000 | 0 | -200,000 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 300,101 | 95,330 | -204,771 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 1,157,452 | 0 | -1,157,452 | 0.12 | 0.00 | -0.12 | sell |
| FMR LLC | 5,131,433 | 264,687 | -4,866,746 | 0.00 | 0.00 | -0.00 | sell |