| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 0 | 788,867 | +788,867 | 0.00 | 0.15 | +0.15 | buy |
| TWO SIGMA INVESTMENTS, LP | 152,233 | 788,695 | +636,462 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 992,854 | 1,413,986 | +421,132 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 273,883 | +273,883 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 135,909 | +135,909 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 122,752 | +122,752 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 0 | 111,040 | +111,040 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 73,000 | +73,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 59,168 | +59,168 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 217,568 | 272,886 | +55,318 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 50,007 | +50,007 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 46,090 | +46,090 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 79,327 | 117,477 | +38,150 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 15,578 | 50,159 | +34,581 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 97,592 | 127,292 | +29,700 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 21,551 | +21,551 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 222,700 | 237,300 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 36,421 | 50,120 | +13,699 | 0.00 | 0.00 | +0.00 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 264,973 | 266,280 | +1,307 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,252 | 70,546 | +1,294 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 52 | 95 | +43 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 10,909,256 | 10,909,256 | 0 | 0.38 | 0.65 | +0.27 | hold |
| TD ASSET MANAGEMENT INC | 160,652 | 160,652 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,500 | 53,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,123,824 | 10,123,824 | 0 | 0.11 | 0.17 | +0.07 | hold |
| SBI Securities Co., Ltd. | 2,741 | 2,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,634 | 1,634 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 18 | 1 | -17 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 89 | 0 | -89 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 13,747 | 13,652 | -95 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 8,712 | 8,602 | -110 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 153 | 0 | -153 | 0.00 | 0.00 | 0.00 | sell |
| Cerity Partners LLC | 34,333 | 32,953 | -1,380 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 9,099 | 6,152 | -2,947 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 540,565 | 535,703 | -4,862 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 5,975 | 0 | -5,975 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,927 | 0 | -6,927 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 25,840 | 15,520 | -10,320 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,500 | 0 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 16,901 | 0 | -16,901 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 75,161 | 0 | -75,161 | 0.01 | 0.00 | -0.01 | sell |
| Shay Capital LLC | 100,000 | 0 | -100,000 | 0.03 | 0.00 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 876,338 | 755,956 | -120,382 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 544,000 | 271,300 | -272,700 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,147,044 | 150,997 | -996,047 | 0.00 | 0.00 | -0.00 | sell |