| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | 3,750,000 | +3,750,000 | 0.00 | 0.57 | +0.57 | buy |
| Deep Track Capital, LP | 0 | 3,706,734 | +3,706,734 | 0.00 | 0.38 | +0.38 | buy |
| T. Rowe Price Investment Management, Inc. | 9,865,558 | 13,432,540 | +3,566,982 | 0.04 | 0.06 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,644,957 | 8,122,179 | +3,477,222 | 0.05 | 0.08 | +0.03 | buy |
| BlackRock, Inc. | 510,806 | 3,935,810 | +3,425,004 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 5,539,724 | 6,892,033 | +1,352,309 | 2.36 | 3.21 | +0.85 | buy |
| Boxer Capital Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.52 | +0.52 | buy |
| Prosight Management, LP | 5,004,439 | 5,957,877 | +953,438 | 5.28 | 7.12 | +1.85 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 645,705 | 1,584,756 | +939,051 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,782,788 | 2,641,076 | +858,288 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 1,368,223 | 1,871,442 | +503,219 | 0.11 | 0.14 | +0.03 | buy |
| NORTHERN TRUST CORP | 126,061 | 520,316 | +394,255 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 800,000 | 1,157,216 | +357,216 | 0.48 | 0.74 | +0.26 | buy |
| Aberdeen Group plc | 1,159,321 | 1,405,851 | +246,530 | 0.01 | 0.01 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 65,400 | 263,418 | +198,018 | 0.01 | 0.04 | +0.03 | buy |
| West Tower Group, LLC | 0 | 191,625 | +191,625 | 0.00 | 3.73 | +3.73 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 189,899 | +189,899 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 382,648 | 558,876 | +176,228 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 139,304 | 286,489 | +147,185 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,031,049 | 1,170,732 | +139,683 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 604,500 | 743,761 | +139,261 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 286,072 | 421,187 | +135,115 | 0.03 | 0.03 | +0.01 | buy |
| Bank of New York Mellon Corp | 89,774 | 218,505 | +128,731 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 81,422 | +81,422 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 71,488 | +71,488 | 0.00 | 0.00 | +0.00 | buy |
| Coastline Trust Co | 0 | 70,000 | +70,000 | 0.00 | 0.04 | +0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 68,371 | +68,371 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 24,686 | 88,800 | +64,114 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 55,367 | +55,367 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 52,745 | +52,745 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 31,162 | 71,547 | +40,385 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 37,420 | +37,420 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 33,190 | +33,190 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 28,127 | +28,127 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 28,062 | +28,062 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 26,387 | +26,387 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 25,668 | +25,668 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 21,785 | +21,785 | 0.00 | 0.02 | +0.02 | buy |
| MGO ONE SEVEN LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 18,092 | +18,092 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 14,641 | +14,641 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,035 | +12,035 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,778 | +11,778 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,594 | +10,594 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 5,956 | +5,956 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,567 | +5,567 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 5,417 | +5,417 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 5,133 | +5,133 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,640 | 9,217 | +3,577 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 845 | +845 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 491 | +491 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 348 | +348 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 392,500 | 392,596 | +96 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 6,306,127 | 6,306,127 | 0 | 0.88 | 0.83 | -0.06 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 42,300 | 42,300 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Creative Planning | 12,335 | 12,335 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LBJ Family Wealth Advisors, Ltd. | 82,177 | 82,177 | 0 | 0.29 | 0.29 | -0.00 | hold |
| CHOREO, LLC | 27,251 | 27,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RITHOLTZ WEALTH MANAGEMENT | 26,000 | 26,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Davis Asset Management, L.P. | 48,276 | 48,276 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Pathstone Holdings, LLC | 73,956 | 73,956 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mallini Complete Financial Planning LLC | 22,632 | 22,632 | 0 | 0.12 | 0.11 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 155,642 | 155,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 50 | 21 | -29 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 66 | 2 | -64 | 0.00 | 0.00 | -0.00 | sell |
| BENJAMIN EDWARDS INC | 23,400 | 17,290 | -6,110 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 8,010 | 0 | -8,010 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 11,533 | 0 | -11,533 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 12,134 | 0 | -12,134 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 16,087 | 0 | -16,087 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 17,900 | 0 | -17,900 | 0.02 | 0.00 | -0.02 | sell |
| Diametric Capital, LP | 18,434 | 0 | -18,434 | 0.03 | 0.00 | -0.03 | sell |
| Dynamic Technology Lab Private Ltd | 29,588 | 0 | -29,588 | 0.03 | 0.00 | -0.03 | sell |
| OMERS ADMINISTRATION Corp | 33,300 | 0 | -33,300 | 0.00 | 0.00 | -0.00 | sell |
| PIPER SANDLER & CO. | 39,467 | 0 | -39,467 | 0.25 | 0.00 | -0.25 | sell |
| EP Wealth Advisors, LLC | 41,167 | 0 | -41,167 | 0.00 | 0.00 | -0.00 | sell |
| CLARK ESTATES INC/NY | 1,475,648 | 1,430,167 | -45,481 | 2.28 | 2.29 | +0.01 | sell |
| CITIGROUP INC | 75,005 | 28,771 | -46,234 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 48,127 | 0 | -48,127 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 142,466 | 93,754 | -48,712 | 0.02 | 0.01 | -0.01 | sell |
| Persistent Asset Partners Ltd | 74,229 | 0 | -74,229 | 0.19 | 0.00 | -0.19 | sell |
| Brevan Howard Capital Management LP | 79,476 | 0 | -79,476 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 79,924 | 0 | -79,924 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 90,698 | 0 | -90,698 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 119,879 | 17,374 | -102,505 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 126,798 | 0 | -126,798 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 316,012 | 185,947 | -130,065 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 148,021 | 0 | -148,021 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 280,786 | 86,461 | -194,325 | 0.31 | 0.09 | -0.22 | sell |
| Hudson Bay Capital Management LP | 228,817 | 0 | -228,817 | 0.01 | 0.00 | -0.01 | sell |
| DIADEMA PARTNERS LP | 293,664 | 0 | -293,664 | 0.78 | 0.00 | -0.78 | sell |
| JANE STREET GROUP, LLC | 415,938 | 0 | -415,938 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 763,745 | 194,008 | -569,737 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 581,471 | 0 | -581,471 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 715,965 | 0 | -715,965 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 905,707 | 35,549 | -870,158 | 0.00 | 0.00 | -0.00 | sell |