| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 6,306,127 | +6,306,127 | 0.00 | 0.36 | +0.36 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,675,000 | 6,306,127 | +1,631,127 | 0.01 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 1,131,888 | +1,131,888 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 656,653 | +656,653 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 1,095,000 | 1,532,216 | +437,216 | 0.09 | 0.33 | +0.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 76,934 | 408,598 | +331,664 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 38,100 | 216,867 | +178,767 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 14,000 | 112,677 | +98,677 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 94,504 | +94,504 | 0.00 | 0.00 | +0.00 | buy |
| LBJ Family Wealth Advisors, Ltd. | 0 | 82,177 | +82,177 | 0.00 | 0.11 | +0.11 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 260,958 | 329,288 | +68,330 | 0.00 | 0.00 | +0.00 | buy |
| Keel Point, LLC | 0 | 46,173 | +46,173 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 26,226 | +26,226 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 1,363,723 | 1,388,723 | +25,000 | 0.02 | 0.04 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 19,260 | +19,260 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 17,700 | +17,700 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 16,054 | +16,054 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 12,335 | +12,335 | 0.00 | 0.00 | +0.00 | buy |
| Turtle Creek Wealth Advisors, LLC | 0 | 12,235 | +12,235 | 0.00 | 0.00 | +0.00 | buy |
| AssuredPartners Investment Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 8,588 | 15,108 | +6,520 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 3,812 | 8,863 | +5,051 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| CLARK ESTATES INC/NY | 1,475,648 | 1,475,648 | 0 | 0.26 | 0.81 | +0.54 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 467,959 | 467,959 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 110,394 | 110,394 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 515,619 | 515,619 | 0 | 2.09 | 7.53 | +5.44 | hold |
| Redmile Group, LLC | 5,539,724 | 5,539,724 | 0 | 0.47 | 1.29 | +0.82 | hold |
| RITHOLTZ WEALTH MANAGEMENT | 26,000 | 26,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PIPER SANDLER & CO. | 39,467 | 39,467 | 0 | 0.02 | 0.07 | +0.04 | hold |
| STATE STREET CORP | 176,718 | 176,718 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,906 | 20,881 | -25 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 142 | 92 | -50 | 0.00 | 0.00 | +0.00 | sell |
| CHOREO, LLC | 27,319 | 27,251 | -68 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 112 | 0 | -112 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 155 | 0 | -155 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 13,826 | 13,670 | -156 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 686 | 0 | -686 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 1,090 | 370 | -720 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,156 | 0 | -1,156 | 0.00 | 0.00 | 0.00 | sell |
| BARCLAYS PLC | 2,114 | 0 | -2,114 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,171 | 958 | -2,213 | 0.00 | 0.00 | -0.00 | sell |
| Briaud Financial Planning, Inc | 2,227 | 0 | -2,227 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,989 | 0 | -2,989 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 8,438 | 3,367 | -5,071 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 28,908 | 14,454 | -14,454 | 0.00 | 0.01 | +0.00 | sell |
| HSBC HOLDINGS PLC | 16,122 | 0 | -16,122 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 16,886 | 0 | -16,886 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 110,983 | 91,272 | -19,711 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 2,148,174 | 2,128,401 | -19,773 | 0.00 | 0.00 | +0.00 | sell |
| Mallini Complete Financial Planning LLC | 22,632 | 0 | -22,632 | 0.00 | 0.00 | -0.00 | sell |
| Summit Trail Advisors, LLC | 23,629 | 0 | -23,629 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 34,525 | 0 | -34,525 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 35,780 | 0 | -35,780 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 38,004 | 0 | -38,004 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 55,380 | 15,951 | -39,429 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 92,300 | 42,300 | -50,000 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 102,948 | 0 | -102,948 | 0.01 | 0.00 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 123,172 | 0 | -123,172 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 843,256 | 690,901 | -152,355 | 0.00 | 0.00 | +0.00 | sell |
| Pathstone Holdings, LLC | 314,166 | 157,083 | -157,083 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 289,671 | 0 | -289,671 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 325,254 | 0 | -325,254 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 881,388 | 411,292 | -470,096 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 6,638,935 | 5,451,195 | -1,187,740 | 1.28 | 3.13 | +1.85 | sell |