| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 1,137,108 | +1,137,108 | 0.00 | 1.73 | +1.73 | buy |
| Qube Research & Technologies Ltd | 242,908 | 723,163 | +480,255 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 437,503 | 897,461 | +459,958 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 125,000 | 550,339 | +425,339 | 0.17 | 0.84 | +0.68 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 398,436 | +398,436 | 0.00 | 1.05 | +1.05 | buy |
| RTW INVESTMENTS, LP | 5,469,956 | 5,845,956 | +376,000 | 0.58 | 0.81 | +0.24 | buy |
| DIMENSIONAL FUND ADVISORS LP | 975,279 | 1,304,812 | +329,533 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 315,460 | +315,460 | 0.00 | 0.33 | +0.33 | buy |
| Point72 Asset Management, L.P. | 0 | 223,400 | +223,400 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 346,850 | 535,062 | +188,212 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 172,660 | +172,660 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 171,507 | +171,507 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 158,935 | +158,935 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 149,627 | +149,627 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 497,679 | 625,176 | +127,497 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 123,408 | +123,408 | 0.00 | 0.01 | +0.01 | buy |
| Simplify Asset Management Inc. | 563,325 | 676,031 | +112,706 | 0.59 | 0.61 | +0.02 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 89,547 | +89,547 | 0.00 | 0.22 | +0.22 | buy |
| Brevan Howard Capital Management LP | 0 | 88,483 | +88,483 | 0.00 | 0.08 | +0.08 | buy |
| STATE STREET CORP | 183,147 | 256,861 | +73,714 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 65,600 | +65,600 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 54,560 | +54,560 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 49,518 | +49,518 | 0.00 | 0.04 | +0.04 | buy |
| Trexquant Investment LP | 0 | 47,222 | +47,222 | 0.00 | 0.01 | +0.01 | buy |
| Marathon Trading Investment Management LLC | 0 | 45,000 | +45,000 | 0.00 | 0.17 | +0.17 | buy |
| Centiva Capital, LP | 0 | 43,080 | +43,080 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 30,183 | 72,768 | +42,585 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 16,418 | 54,416 | +37,998 | 0.01 | 0.04 | +0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 32,591 | +32,591 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 30,844 | +30,844 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 30,739 | +30,739 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 376,573 | 407,108 | +30,535 | 0.68 | 1.03 | +0.34 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 64,754 | 94,775 | +30,021 | 0.04 | 0.08 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 64,623 | 92,204 | +27,581 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 476,206 | 496,679 | +20,473 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 18,874 | +18,874 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 2,519,984 | 2,538,665 | +18,681 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 17,539 | +17,539 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,162 | +15,162 | 0.00 | 0.01 | +0.01 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 14,700 | +14,700 | 0.00 | 0.09 | +0.09 | buy |
| STIFEL FINANCIAL CORP | 71,455 | 85,014 | +13,559 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,154 | +13,154 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 0 | 12,658 | +12,658 | 0.00 | 0.02 | +0.02 | buy |
| Corton Capital Inc. | 0 | 12,453 | +12,453 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 0 | 12,206 | +12,206 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 10,600 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 553,230 | 563,458 | +10,228 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 13,747 | 23,579 | +9,832 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 94,617 | 102,226 | +7,609 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,658 | 9,851 | +6,193 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 4,200 | 9,000 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,150 | 11,916 | +4,766 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 4,365 | +4,365 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 39,854 | 43,682 | +3,828 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 68,185 | 71,515 | +3,330 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 1,210 | +1,210 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,038 | +1,038 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 10,000 | 10,900 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 790 | 1,673 | +883 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 20,359 | 20,853 | +494 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,023 | 2,482 | +459 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 44 | 75 | +31 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 1,657 | 1,657 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 140,000 | 140,000 | 0 | 0.06 | 0.07 | +0.02 | hold |
| BRANDYWINE MANAGERS, LLC | 26,127 | 26,127 | 0 | 0.19 | 0.24 | +0.05 | hold |
| COUNTRY TRUST BANK | 30,186 | 30,186 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 11,609,704 | 11,609,704 | 0 | 1.22 | 1.39 | +0.17 | hold |
| Laurion Capital Management LP | 144,721 | 144,721 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Blackstone Inc. | 19,216 | 19,216 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 202,148 | 202,148 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 727,673 | 727,673 | 0 | 0.12 | 0.17 | +0.05 | hold |
| Opaleye Management Inc. | 130,000 | 130,000 | 0 | 0.23 | 0.27 | +0.03 | hold |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.00 | 0.01 | +0.00 | hold |
| TRV GP IV, LLC | 2,343,154 | 2,343,154 | 0 | 6.43 | 10.72 | +4.29 | hold |
| Aberdeen Group plc | 256,888 | 256,888 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PrairieView Partners, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Propel Bio Management, LLC | 750,000 | 750,000 | 0 | 4.20 | 4.12 | -0.08 | hold |
| BROWN WEALTH MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.07 | 0.10 | +0.02 | hold |
| Susquehanna Portfolio Strategies, LLC | 168,775 | 168,775 | 0 | 0.02 | 0.04 | +0.02 | hold |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.02 | 0.02 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 24,821 | 24,821 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,900 | 15,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,485 | 24,485 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 460 | 460 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,542 | 1,542 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 823,098 | 823,098 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 17,993 | 16,233 | -1,760 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 144,965 | 136,433 | -8,532 | 0.00 | 0.00 | +0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 11,684 | 0 | -11,684 | 0.04 | 0.00 | -0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 11,730 | 0 | -11,730 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 25,830 | 13,670 | -12,160 | 0.01 | 0.01 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 96,428 | 83,428 | -13,000 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 14,200 | 0 | -14,200 | 0.00 | 0.00 | -0.00 | sell |
| LM Advisors LLC | 16,132 | 0 | -16,132 | 0.02 | 0.00 | -0.02 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 16,914 | 0 | -16,914 | 0.02 | 0.00 | -0.02 | sell |