| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,561,111 | 6,561,111 | 0 | 1.85 | 1.36 | -0.49 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,053,960 | 6,053,960 | 0 | 0.70 | 0.49 | -0.21 | hold |
| BlackRock, Inc. | 4,263,761 | 5,390,593 | +1,126,832 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 5,250,000 | 5,250,000 | 0 | 1.97 | 1.15 | -0.81 | hold |
| BRAIDWELL LP | 3,061,222 | 3,134,922 | +73,700 | 1.11 | 0.80 | -0.31 | buy |
| Nantahala Capital Management, LLC | 4,293,346 | 3,050,040 | -1,243,306 | 2.89 | 1.46 | -1.43 | sell |
| Siren, L.L.C. | 1,950,000 | 2,350,000 | +400,000 | 0.66 | 0.50 | -0.16 | buy |
| First Turn Management, LLC | 1,892,683 | 2,256,109 | +363,426 | 2.45 | 1.93 | -0.51 | buy |
| Aberdeen Group plc | 1,254,027 | 2,211,953 | +957,926 | 0.02 | 0.03 | +0.01 | buy |
| Point72 Asset Management, L.P. | 2,398,232 | 2,074,855 | -323,377 | 0.04 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 970,439 | 1,779,946 | +809,507 | 0.02 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,913,755 | 1,623,281 | -290,474 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 1,005,345 | 1,549,851 | +544,506 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,105,813 | 1,486,542 | +380,729 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,328,449 | +1,328,449 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 1,207,004 | 1,292,486 | +85,482 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 1,193,873 | +1,193,873 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,051,124 | 1,130,281 | +79,157 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 950,000 | 1,100,000 | +150,000 | 0.39 | 0.24 | -0.16 | buy |
| Ikarian Capital, LLC | 1,375,472 | 1,049,161 | -326,311 | 2.01 | 1.15 | -0.86 | sell |
| Qube Research & Technologies Ltd | 392,489 | 974,739 | +582,250 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 582,377 | 736,684 | +154,307 | 0.02 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 736,740 | 727,315 | -9,425 | 0.01 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 323,879 | 571,909 | +248,030 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,502 | 543,165 | +527,663 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 552,220 | 472,985 | -79,235 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 355,547 | 453,529 | +97,982 | 0.04 | 0.03 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 388,896 | 426,869 | +37,973 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 394,650 | 419,949 | +25,299 | 0.65 | 0.38 | -0.27 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,700,000 | 400,000 | -1,300,000 | 0.03 | 0.00 | -0.02 | sell |
| Jump Financial, LLC | 92,200 | 369,805 | +277,605 | 0.01 | 0.04 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 54,431 | 356,471 | +302,040 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 102,967 | 315,185 | +212,218 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 493,750 | 310,417 | -183,333 | 0.01 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 517,526 | 303,988 | -213,538 | 0.15 | 0.05 | -0.10 | sell |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 0 | 243,565 | +243,565 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 205,000 | +205,000 | 0.00 | 0.36 | +0.36 | buy |
| Squarepoint Ops LLC | 65,852 | 175,944 | +110,092 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 165,623 | 173,337 | +7,714 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 157,672 | 156,242 | -1,430 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 86,499 | 154,435 | +67,936 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 66,716 | 153,344 | +86,628 | 0.02 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 116,906 | 149,942 | +33,036 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 139,000 | +139,000 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 99,709 | 136,664 | +36,955 | 0.10 | 0.07 | -0.03 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.02 | 0.01 | -0.01 | hold |
| ADAR1 Capital Management, LLC | 1,253,749 | 130,560 | -1,123,189 | 1.06 | 0.06 | -1.00 | sell |
| Nuveen, LLC | 112,203 | 129,618 | +17,415 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 231,177 | 126,559 | -104,618 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 126,109 | +126,109 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 146,427 | 118,600 | -27,827 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 159,674 | 115,994 | -43,680 | 0.03 | 0.01 | -0.02 | sell |
| Invesco Ltd. | 417,189 | 111,125 | -306,064 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,930 | 101,336 | +13,406 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 132,541 | 88,458 | -44,083 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 63,760 | 80,169 | +16,409 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 3,574 | 79,157 | +75,583 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 51,802 | 71,603 | +19,801 | 0.02 | 0.01 | -0.01 | buy |
| RBF Capital, LLC | 80,506 | 70,000 | -10,506 | 0.04 | 0.03 | -0.02 | sell |
| Atom Investors LP | 60,595 | 69,155 | +8,560 | 0.05 | 0.04 | -0.02 | buy |
| RHUMBLINE ADVISERS | 55,713 | 66,175 | +10,462 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 22,104 | 64,089 | +41,985 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,691 | 61,041 | +53,350 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 43,262 | 58,636 | +15,374 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 44,249 | 54,666 | +10,417 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 34,750 | 53,756 | +19,006 | 0.01 | 0.01 | +0.00 | buy |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| STRS OHIO | 49,300 | 49,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 287,096 | 48,828 | -238,268 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 15,253 | 46,119 | +30,866 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 15,076 | 45,248 | +30,172 | 0.07 | 0.10 | +0.04 | buy |
| Graham Capital Management, L.P. | 48,464 | 42,741 | -5,723 | 0.02 | 0.01 | -0.01 | sell |
| Marex Group plc | 0 | 42,000 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 8,014 | 41,940 | +33,926 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 40,000 | 40,290 | +290 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| Matisse Capital | 13,460 | 39,649 | +26,189 | 0.07 | 0.13 | +0.06 | buy |
| Brevan Howard Capital Management LP | 48,900 | 39,444 | -9,456 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 15,270 | 34,570 | +19,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,714 | 33,164 | +10,450 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 33,050 | +33,050 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 30,793 | 30,793 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COUNTRY TRUST BANK | 30,041 | 30,041 | 0 | 0.01 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 20,789 | 29,792 | +9,003 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,022 | 28,080 | +8,058 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 0 | 26,100 | +26,100 | 0.00 | 0.02 | +0.02 | buy |
| Quantinno Capital Management LP | 29,264 | 25,669 | -3,595 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 67,102 | 23,435 | -43,667 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 0 | 23,260 | +23,260 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 23,172 | +23,172 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 166,395 | 22,551 | -143,844 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 31,545 | 22,043 | -9,502 | 0.08 | 0.02 | -0.06 | sell |
| Virtus Investment Advisers, LLC | 20,463 | 20,974 | +511 | 0.06 | 0.04 | -0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 19,321 | +19,321 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,843 | 18,562 | +5,719 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 18,400 | +18,400 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 16,373 | 17,704 | +1,331 | 0.00 | 0.00 | -0.00 | buy |
| Westshore Wealth, LLC | 0 | 17,000 | +17,000 | 0.00 | 0.05 | +0.05 | buy |