| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11,609,704 | 11,609,704 | 0 | 1.39 | 0.95 | -0.44 | hold |
| RTW INVESTMENTS, LP | 5,845,956 | 5,845,956 | 0 | 0.81 | 0.56 | -0.25 | hold |
| FMR LLC | 5,364,665 | 5,329,946 | -34,719 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,538,665 | 3,071,143 | +532,478 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,848,486 | 2,541,046 | -307,440 | 1.13 | 0.64 | -0.49 | sell |
| TRV GP IV, LLC | 2,343,154 | 2,343,154 | 0 | 10.72 | 7.18 | -3.53 | hold |
| CITADEL ADVISORS LLC | 1,325,379 | 1,777,112 | +451,733 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,304,812 | 1,480,926 | +176,114 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 1,137,108 | 1,444,851 | +307,743 | 1.73 | 1.39 | -0.33 | buy |
| Jefferies Financial Group Inc. | 1,151,726 | 1,433,316 | +281,590 | 0.22 | 0.17 | -0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 563,458 | 1,307,377 | +743,919 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,157,137 | 1,234,813 | +77,676 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 695,000 | 1,160,000 | +465,000 | 0.54 | 0.54 | -0.01 | buy |
| STATE STREET CORP | 256,861 | 1,041,274 | +784,413 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 823,098 | 849,193 | +26,095 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 750,000 | 750,000 | 0 | 4.12 | 3.02 | -1.11 | hold |
| Rock Springs Capital Management LP | 727,673 | 727,673 | 0 | 0.17 | 0.14 | -0.04 | hold |
| STEMPOINT CAPITAL LP | 407,108 | 696,464 | +289,356 | 1.03 | 1.27 | +0.24 | buy |
| Simplify Asset Management Inc. | 676,031 | 674,832 | -1,199 | 0.61 | 0.37 | -0.24 | sell |
| D. E. Shaw & Co., Inc. | 625,176 | 591,785 | -33,391 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 420,200 | 563,500 | +143,300 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 810,270 | 560,492 | -249,778 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 723,163 | 553,307 | -169,856 | 0.01 | 0.01 | -0.01 | sell |
| Caption Management, LLC | 315,460 | 525,300 | +209,840 | 0.33 | 0.35 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 175,224 | 509,688 | +334,464 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 0 | 501,301 | +501,301 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 0 | 497,456 | +497,456 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 897,461 | 402,749 | -494,712 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 398,436 | 398,436 | 0 | 1.05 | 0.61 | -0.44 | hold |
| ADAR1 Capital Management, LLC | 339,825 | 368,369 | +28,544 | 0.88 | 0.46 | -0.42 | buy |
| MARSHALL WACE, LLP | 225,573 | 333,161 | +107,588 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 302,700 | +302,700 | 0.00 | 1.67 | +1.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,106,422 | 300,000 | -806,422 | 0.02 | 0.00 | -0.02 | sell |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Opaleye Management Inc. | 130,000 | 285,000 | +155,000 | 0.27 | 0.40 | +0.14 | buy |
| Aberdeen Group plc | 256,888 | 256,888 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 186,965 | 222,982 | +36,017 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 202,148 | 202,148 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS Group AG | 72,768 | 190,551 | +117,783 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 186,727 | +186,727 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 172,660 | 182,729 | +10,069 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,485 | 175,983 | +151,498 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 535,062 | 168,244 | -366,818 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 136,433 | 166,894 | +30,461 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 0 | 152,965 | +152,965 | 0.00 | 0.07 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 21,419 | 150,505 | +129,086 | 0.00 | 0.01 | +0.01 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.02 | 0.01 | -0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 15,162 | 135,221 | +120,059 | 0.01 | 0.06 | +0.05 | buy |
| RBF Capital, LLC | 140,000 | 125,000 | -15,000 | 0.07 | 0.05 | -0.03 | sell |
| AMERICAN CENTURY COMPANIES INC | 92,204 | 104,371 | +12,167 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 30,844 | 94,181 | +63,337 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,657 | 91,432 | +89,775 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 85,014 | 87,607 | +2,593 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 83,428 | 84,428 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 560,992 | 81,595 | -479,397 | 0.01 | 0.00 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 168,775 | 81,217 | -87,558 | 0.04 | 0.02 | -0.02 | sell |
| Trexquant Investment LP | 47,222 | 70,506 | +23,284 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 61,653 | 69,886 | +8,233 | 0.00 | 0.00 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alpine Global Management, LLC | 0 | 59,983 | +59,983 | 0.00 | 0.06 | +0.06 | buy |
| GROUP ONE TRADING LLC | 20,853 | 59,395 | +38,542 | 0.01 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 30,739 | 57,133 | +26,394 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 43,682 | 48,479 | +4,797 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 13,670 | 41,303 | +27,633 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,900 | 35,712 | +19,812 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 32,282 | +32,282 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 496,679 | 31,043 | -465,636 | 0.00 | 0.00 | -0.00 | sell |
| COUNTRY TRUST BANK | 30,186 | 30,186 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 28,100 | +28,100 | 0.00 | 0.01 | +0.01 | buy |
| Semanteon Capital Management, LP | 0 | 26,658 | +26,658 | 0.00 | 0.12 | +0.12 | buy |
| BARCLAYS PLC | 71,515 | 26,576 | -44,939 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 12,453 | 26,172 | +13,719 | 0.04 | 0.09 | +0.04 | buy |
| AlphaQuest LLC | 0 | 26,164 | +26,164 | 0.00 | 0.02 | +0.02 | buy |
| BRANDYWINE MANAGERS, LLC | 26,127 | 26,127 | 0 | 0.24 | 0.17 | -0.07 | hold |
| SG Americas Securities, LLC | 12,206 | 26,093 | +13,887 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 25,120 | +25,120 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 25,100 | +25,100 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 24,821 | 24,821 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 54,560 | 24,517 | -30,043 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 24,480 | +24,480 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 178,564 | 22,791 | -155,773 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 21,154 | +21,154 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 21,038 | +21,038 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 19,860 | +19,860 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 19,311 | +19,311 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 9,000 | 17,300 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,851 | 16,324 | +6,473 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 15,898 | +15,898 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Quantbot Technologies LP | 0 | 14,029 | +14,029 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 13,257 | +13,257 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 11,606 | +11,606 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 15,709 | 11,367 | -4,342 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 10,921 | +10,921 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 45,000 | 10,800 | -34,200 | 0.17 | 0.02 | -0.15 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 94,775 | 10,489 | -84,286 | 0.08 | 0.01 | -0.07 | sell |
| China Universal Asset Management Co., Ltd. | 11,916 | 7,301 | -4,615 | 0.01 | 0.01 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 0 | 6,079 | +6,079 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| PrairieView Partners, LLC | 5,000 | 5,000 | 0 | 0.01 | 0.00 | -0.00 | hold |