| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,229,099 | 10,229,099 | 0 | 0.49 | 1.19 | +0.69 | hold |
| TCG Crossover Management, LLC | 5,250,000 | 5,250,000 | 0 | 2.06 | 4.13 | +2.06 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,067,394 | 5,082,900 | +15,506 | 0.59 | 1.32 | +0.73 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,000,000 | 4,589,000 | +1,589,000 | 0.02 | 0.05 | +0.04 | buy |
| BlackRock, Inc. | 4,710,697 | 4,379,023 | -331,674 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 4,822,693 | 4,288,299 | -534,394 | 1.15 | 2.09 | +0.94 | sell |
| VANGUARD GROUP INC | 3,220,378 | 3,146,443 | -73,935 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,407,049 | 1,372,637 | -34,412 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,338,214 | +1,338,214 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 1,252,440 | 1,218,366 | -34,074 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,231,375 | 1,193,138 | -38,237 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 580,661 | 1,176,711 | +596,050 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 402,600 | 1,143,536 | +740,936 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 897,617 | 897,617 | 0 | 0.02 | 0.03 | +0.02 | hold |
| NORTHERN TRUST CORP | 640,947 | 611,536 | -29,411 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 344,561 | 563,380 | +218,819 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 498,219 | +498,219 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 85,767 | 470,333 | +384,566 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 689,137 | 444,949 | -244,188 | 1.78 | 2.52 | +0.75 | sell |
| Ikarian Capital, LLC | 200,096 | 428,521 | +228,425 | 0.19 | 0.98 | +0.79 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,359 | 387,782 | +6,423 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 217,749 | 342,547 | +124,798 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 314,410 | +314,410 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 279,812 | 279,251 | -561 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 204,400 | +204,400 | 0.00 | 0.01 | +0.01 | buy |
| Catalio Capital Management, LP | 202,139 | 188,304 | -13,835 | 0.14 | 0.27 | +0.13 | sell |
| CITADEL ADVISORS LLC | 374,256 | 166,234 | -208,022 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 192,207 | 143,129 | -49,078 | 0.06 | 0.10 | +0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 59,533 | 141,378 | +81,845 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 143,588 | 137,000 | -6,588 | 0.00 | 0.00 | +0.00 | sell |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.01 | +0.01 | hold |
| UBS Group AG | 0 | 135,205 | +135,205 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 123,711 | 132,349 | +8,638 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 126,402 | +126,402 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 152,992 | 124,723 | -28,269 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 82,457 | 112,063 | +29,606 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 150,643 | 111,582 | -39,061 | 0.01 | 0.02 | +0.01 | sell |
| SIMPLEX TRADING, LLC | 3,026 | 109,365 | +106,339 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 40,692 | 105,693 | +65,001 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 99,490 | +99,490 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97,600 | 97,600 | 0 | 0.01 | 0.02 | +0.01 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 147,654 | 92,470 | -55,184 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 91,015 | +91,015 | 0.00 | 0.02 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 83,428 | 83,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 88,993 | 83,250 | -5,743 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 277,800 | 82,100 | -195,700 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 80,506 | 80,506 | 0 | 0.01 | 0.03 | +0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 401,100 | 78,500 | -322,600 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 91,200 | 75,100 | -16,100 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 65,590 | 74,590 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 81,134 | 73,154 | -7,980 | 0.01 | 0.03 | +0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,168 | 69,028 | -1,140 | 0.00 | 0.00 | +0.00 | sell |
| J. Goldman & Co LP | 20,250 | 67,500 | +47,250 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 24,821 | 60,022 | +35,201 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 59,650 | +59,650 | 0.00 | 0.57 | +0.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 150,274 | 58,965 | -91,309 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 0 | 58,696 | +58,696 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 490,532 | 53,349 | -437,183 | 0.27 | 0.06 | -0.21 | sell |
| LMR Partners LLP | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 74,961 | 49,536 | -25,425 | 0.00 | 0.00 | +0.00 | sell |
| Integrated Quantitative Investments LLC | 0 | 41,106 | +41,106 | 0.00 | 0.08 | +0.08 | buy |
| Allostery Investments LP | 0 | 40,353 | +40,353 | 0.00 | 3.54 | +3.54 | buy |
| WELLS FARGO & COMPANY/MN | 30,520 | 33,748 | +3,228 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 32,563 | +32,563 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 17,535 | 32,545 | +15,010 | 0.00 | 0.00 | +0.00 | buy |
| COUNTRY TRUST BANK | 30,186 | 30,186 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,592 | 29,433 | -2,159 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 45,689 | 28,058 | -17,631 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 0 | 27,280 | +27,280 | 0.00 | 0.01 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 55,342 | 27,201 | -28,141 | 0.07 | 0.08 | +0.01 | sell |
| BAILARD, INC. | 0 | 26,881 | +26,881 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 209,893 | 26,162 | -183,731 | 0.00 | 0.00 | -0.00 | sell |
| Matisse Capital | 96,717 | 26,100 | -70,617 | 0.15 | 0.08 | -0.06 | sell |
| CITIGROUP INC | 37,829 | 21,016 | -16,813 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,411 | 19,887 | -2,524 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 17,608 | 18,053 | +445 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,288 | 17,461 | +12,173 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 117,816 | 17,427 | -100,389 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 0 | 16,939 | +16,939 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 0 | 16,502 | +16,502 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,548 | 15,411 | -3,137 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 22,725 | 14,540 | -8,185 | 0.00 | 0.00 | +0.00 | sell |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 13,675 | +13,675 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 13,465 | +13,465 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,100 | 13,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 10,266 | 12,943 | +2,677 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,475 | 12,475 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 166,243 | 12,052 | -154,191 | 0.02 | 0.00 | -0.01 | sell |
| ProShare Advisors LLC | 11,657 | 10,951 | -706 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 216 | 9,308 | +9,092 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,318 | 6,967 | +2,649 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,332 | 6,377 | -1,955 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 12,190 | 6,281 | -5,909 | 0.01 | 0.01 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,079 | 6,079 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 15,586 | 5,999 | -9,587 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 6,792 | 5,619 | -1,173 | 0.00 | 0.00 | +0.00 | sell |
| PrairieView Partners, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |