| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 5,390,593 | 8,824,259 | +3,433,666 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 0 | 6,549,866 | +6,549,866 | 0.00 | 1.19 | +1.19 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 6,521,412 | +6,521,412 | 0.00 | 1.08 | +1.08 | buy |
| Nantahala Capital Management, LLC | 3,050,040 | 5,475,040 | +2,425,000 | 1.46 | 1.21 | -0.25 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 6,561,111 | 3,680,921 | -2,880,190 | 1.36 | 0.28 | -1.08 | sell |
| D. E. Shaw & Co., Inc. | 1,623,281 | 3,044,385 | +1,421,104 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,292,486 | 2,704,505 | +1,412,019 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 310,417 | 2,217,498 | +1,907,081 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,549,851 | 2,037,025 | +487,174 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 2,000,000 | +1,600,000 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 974,739 | 1,748,467 | +773,728 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,600 | 1,647,800 | +1,634,200 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 130,560 | 1,565,029 | +1,434,469 | 0.06 | 0.27 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 356,471 | 1,485,803 | +1,129,332 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,486,542 | 1,432,133 | -54,409 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 1,358,423 | +1,358,423 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 315,185 | 1,253,909 | +938,724 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 101,336 | 1,180,946 | +1,079,610 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 543,165 | 1,103,261 | +560,096 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 571,909 | 1,094,425 | +522,516 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 1,049,161 | 1,049,161 | 0 | 1.15 | 0.63 | -0.52 | hold |
| BANK OF AMERICA CORP /DE/ | 126,559 | 1,043,029 | +916,470 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 727,315 | 1,038,797 | +311,482 | 0.01 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 369,805 | 1,005,000 | +635,195 | 0.04 | 0.03 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,130,281 | 960,547 | -169,734 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 1,193,873 | 835,204 | -358,669 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 139,000 | 812,766 | +673,766 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 736,684 | 745,317 | +8,633 | 0.01 | 0.01 | -0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,779,946 | 692,372 | -1,087,574 | 0.03 | 0.00 | -0.02 | sell |
| Y-Intercept (Hong Kong) Ltd | 153,344 | 681,832 | +528,488 | 0.02 | 0.05 | +0.03 | buy |
| Point72 Asset Management, L.P. | 2,074,855 | 651,427 | -1,423,428 | 0.03 | 0.00 | -0.02 | sell |
| NORTHERN TRUST CORP | 472,985 | 487,869 | +14,884 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 433,220 | +433,220 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 426,869 | 433,220 | +6,351 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 303,988 | 303,988 | 0 | 0.05 | 0.02 | -0.03 | hold |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Peapod Lane Capital LLC | 0 | 285,798 | +285,798 | 0.00 | 0.71 | +0.71 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 118,600 | 285,084 | +166,484 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 126,109 | 242,000 | +115,891 | 0.01 | 0.01 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 233,851 | +233,851 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 45,248 | 217,199 | +171,951 | 0.10 | 0.19 | +0.09 | buy |
| XTX Topco Ltd | 71,603 | 209,247 | +137,644 | 0.01 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 189,119 | +189,119 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 156,242 | 155,868 | -374 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 129,618 | 154,871 | +25,253 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 149,942 | 154,513 | +4,571 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 115,994 | 153,794 | +37,800 | 0.01 | 0.01 | -0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 136,664 | 143,911 | +7,247 | 0.07 | 0.03 | -0.03 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Squarepoint Ops LLC | 175,944 | 126,558 | -49,386 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 14,147 | 119,038 | +104,891 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 114,890 | +114,890 | 0.00 | 0.39 | +0.39 | buy |
| Invesco Ltd. | 111,125 | 113,319 | +2,194 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 58,636 | 109,353 | +50,717 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 79,157 | 104,132 | +24,975 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 18,400 | 102,400 | +84,000 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 33,050 | 101,360 | +68,310 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 243,565 | 95,521 | -148,044 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 80,169 | 94,235 | +14,066 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 61,041 | 92,327 | +31,286 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 89,723 | +89,723 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 19,321 | 85,580 | +66,259 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 88,458 | 83,373 | -5,085 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 34,570 | 83,370 | +48,800 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 22,043 | 81,483 | +59,440 | 0.02 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 66,175 | 73,443 | +7,268 | 0.00 | 0.00 | -0.00 | buy |
| RBF Capital, LLC | 70,000 | 70,000 | 0 | 0.03 | 0.01 | -0.02 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 67,857 | +67,857 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 0 | 67,632 | +67,632 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,435 | 62,774 | +39,339 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 56,446 | +56,446 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 48,828 | 52,381 | +3,553 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,551 | 49,696 | +27,145 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 49,300 | 46,200 | -3,100 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 29,792 | 41,371 | +11,579 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 40,290 | 40,000 | -290 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 0 | 38,552 | +38,552 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 33,164 | 34,079 | +915 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 54,666 | 34,063 | -20,603 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 15,501 | 32,514 | +17,013 | 0.00 | 0.00 | -0.00 | buy |
| State of Alaska, Department of Revenue | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 30,681 | +30,681 | 0.00 | 0.00 | +0.00 | buy |
| COUNTRY TRUST BANK | 30,041 | 30,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 29,512 | +29,512 | 0.00 | 0.03 | +0.03 | buy |
| Scientech Research LLC | 0 | 28,584 | +28,584 | 0.00 | 0.08 | +0.08 | buy |
| Mariner, LLC | 23,260 | 28,104 | +4,844 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,080 | 27,325 | -755 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 42,741 | 25,067 | -17,674 | 0.01 | 0.00 | -0.01 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 25,052 | +25,052 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 24,538 | +24,538 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 64,089 | 21,373 | -42,716 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 10,866 | 21,370 | +10,504 | 0.00 | 0.00 | -0.00 | buy |
| Castleview Partners, LLC | 0 | 19,100 | +19,100 | 0.00 | 0.03 | +0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,562 | 18,562 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Westshore Wealth, LLC | 17,000 | 17,000 | 0 | 0.05 | 0.02 | -0.03 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,102 | 16,719 | +617 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 16,596 | +16,596 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,242 | 16,182 | +2,940 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,078 | +16,078 | 0.00 | 0.00 | +0.00 | buy |