| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,229,099 | 10,229,099 | 0 | 1.19 | 1.16 | -0.03 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,082,900 | 5,381,000 | +298,100 | 1.32 | 1.50 | +0.18 | buy |
| TCG Crossover Management, LLC | 5,250,000 | 5,250,000 | 0 | 4.13 | 2.38 | -1.75 | hold |
| Nantahala Capital Management, LLC | 4,288,299 | 4,670,784 | +382,485 | 2.09 | 2.65 | +0.57 | buy |
| BlackRock, Inc. | 4,379,023 | 3,706,750 | -672,273 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 3,146,443 | 2,999,464 | -146,979 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,589,000 | 2,432,000 | -2,157,000 | 0.05 | 0.04 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,338,214 | 1,450,480 | +112,266 | 0.02 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,176,711 | 1,449,423 | +272,712 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,372,637 | 1,299,308 | -73,329 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 428,521 | 1,289,225 | +860,704 | 0.98 | 2.40 | +1.42 | buy |
| STATE STREET CORP | 1,218,366 | 1,063,207 | -155,159 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,193,138 | 1,004,051 | -189,087 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 1,000,849 | +1,000,849 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 166,234 | 854,556 | +688,322 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 141,378 | 678,414 | +537,036 | 0.03 | 0.16 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 1,143,536 | 586,351 | -557,185 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 611,536 | 568,322 | -43,214 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 563,380 | 540,641 | -22,739 | 0.01 | 0.01 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 342,547 | 384,138 | +41,591 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 204,400 | 366,303 | +161,903 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 53,349 | 341,612 | +288,263 | 0.06 | 0.31 | +0.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 387,782 | 333,483 | -54,299 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 17,427 | 321,520 | +304,093 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 135,205 | 301,157 | +165,952 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 279,251 | 285,329 | +6,078 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 78,500 | 248,200 | +169,700 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 314,410 | 243,835 | -70,575 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 0 | 219,488 | +219,488 | 0.00 | 0.06 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,402 | 179,358 | +52,956 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 132,349 | 152,244 | +19,895 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 105,693 | 150,867 | +45,174 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 147,211 | +147,211 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 58,696 | 137,961 | +79,265 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.01 | +0.00 | hold |
| J. Goldman & Co LP | 67,500 | 135,000 | +67,500 | 0.01 | 0.05 | +0.03 | buy |
| HRT FINANCIAL LP | 0 | 124,924 | +124,924 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 124,666 | +124,666 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 470,333 | 123,872 | -346,461 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 137,000 | 119,158 | -17,842 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 32,563 | 116,068 | +83,505 | 0.02 | 0.09 | +0.07 | buy |
| Nuveen, LLC | 124,723 | 112,203 | -12,520 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 111,582 | 111,582 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Campbell & CO Investment Adviser LLC | 0 | 102,470 | +102,470 | 0.00 | 0.07 | +0.07 | buy |
| Exome Asset Management LLC | 444,949 | 98,799 | -346,150 | 2.52 | 0.60 | -1.92 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97,600 | 95,400 | -2,200 | 0.02 | 0.02 | +0.00 | sell |
| BARCLAYS PLC | 112,063 | 89,616 | -22,447 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 83,428 | 83,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Simplify Asset Management Inc. | 73,154 | 83,234 | +10,080 | 0.03 | 0.02 | -0.01 | buy |
| RBF Capital, LLC | 80,506 | 80,506 | 0 | 0.03 | 0.03 | +0.01 | hold |
| STRS OHIO | 75,100 | 77,900 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 74,590 | 74,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 92,470 | 70,015 | -22,455 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 83,250 | 69,372 | -13,878 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 66,550 | +66,550 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69,028 | 65,892 | -3,136 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 6,281 | 62,984 | +56,703 | 0.01 | 0.06 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 60,022 | 60,022 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 59,650 | 57,141 | -2,509 | 0.57 | 0.54 | -0.03 | sell |
| HSBC HOLDINGS PLC | 49,536 | 53,806 | +4,270 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,490 | 53,571 | -45,919 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 50,791 | +50,791 | 0.00 | 0.07 | +0.07 | buy |
| AlphaQuest LLC | 0 | 35,375 | +35,375 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 33,748 | 32,507 | -1,241 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 82,100 | 31,500 | -50,600 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 12,052 | 30,486 | +18,434 | 0.00 | 0.01 | +0.01 | buy |
| COUNTRY TRUST BANK | 30,186 | 30,041 | -145 | 0.00 | 0.01 | +0.00 | sell |
| LMR Partners LLP | 50,000 | 30,000 | -20,000 | 0.01 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 143,129 | 28,832 | -114,297 | 0.10 | 0.02 | -0.08 | sell |
| BAILARD, INC. | 26,881 | 26,881 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 32,545 | 25,895 | -6,650 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 24,649 | +24,649 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 0 | 23,868 | +23,868 | 0.00 | 0.12 | +0.12 | buy |
| Trexquant Investment LP | 0 | 21,015 | +21,015 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,433 | 20,006 | -9,427 | 0.00 | 0.00 | -0.00 | sell |
| Matisse Capital | 26,100 | 18,630 | -7,470 | 0.08 | 0.08 | -0.01 | sell |
| JPMORGAN CHASE & CO | 26,162 | 18,069 | -8,093 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,675 | 17,826 | +4,151 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,058 | 17,244 | -10,814 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 16,550 | +16,550 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 17,461 | 16,373 | -1,088 | 0.00 | 0.00 | +0.00 | sell |
| WINTON GROUP Ltd | 0 | 16,212 | +16,212 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 15,303 | +15,303 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 16,939 | 14,354 | -2,585 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 5,999 | 14,274 | +8,275 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,887 | 13,948 | -5,939 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 9,308 | 13,731 | +4,423 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 13,666 | +13,666 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,943 | 13,168 | +225 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,100 | 13,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 12,475 | 12,843 | +368 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 109,365 | 12,800 | -96,565 | 0.02 | 0.00 | -0.02 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,272 | +11,272 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 91,015 | 10,563 | -80,452 | 0.02 | 0.00 | -0.01 | sell |
| ASSETMARK, INC | 0 | 9,611 | +9,611 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,967 | 7,350 | +383 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 3,415 | 7,112 | +3,697 | 0.00 | 0.00 | +0.00 | buy |