| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.90 | +0.90 | buy |
| DEUTSCHE BANK AG\ | 0 | 823,098 | +823,098 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 259,227 | 871,503 | +612,276 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 476,206 | +476,206 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 432,533 | +432,533 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 561,998 | 975,279 | +413,281 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 38,501 | 346,850 | +308,349 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 911,871 | 1,219,059 | +307,188 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 221,264 | 497,679 | +276,415 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 256,888 | +256,888 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 13,066 | 242,908 | +229,842 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 89,189 | 285,298 | +196,109 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 505,341 | 666,593 | +161,252 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,254,184 | 1,403,873 | +149,689 | 0.01 | 0.01 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 144,721 | +144,721 | 0.00 | 0.04 | +0.04 | buy |
| Opaleye Management Inc. | 0 | 130,000 | +130,000 | 0.00 | 0.23 | +0.23 | buy |
| Affinity Asset Advisors, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.17 | +0.17 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 105,179 | +105,179 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 96,428 | +96,428 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 94,617 | +94,617 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 68,185 | +68,185 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 51,664 | +51,664 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 139,044 | 187,472 | +48,428 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 46,778 | +46,778 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 27,688 | 71,455 | +43,767 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 39,854 | +39,854 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 28,252 | 64,754 | +36,502 | 0.02 | 0.04 | +0.02 | buy |
| UBS Group AG | 0 | 30,183 | +30,183 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 28,600 | +28,600 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 36,939 | 64,623 | +27,684 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 534,503 | 553,230 | +18,727 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 16,914 | +16,914 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 16,418 | +16,418 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 13,747 | +13,747 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 6,773 | 20,359 | +13,586 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 11,730 | +11,730 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,684 | +11,684 | 0.00 | 0.04 | +0.04 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 233,538 | 239,458 | +5,920 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,594 | 7,150 | +5,556 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 4,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 142,981 | 144,965 | +1,984 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 134,811 | 134,850 | +39 | 0.35 | 0.48 | +0.13 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 126,500 | 126,500 | 0 | 0.01 | 0.02 | +0.00 | hold |
| RHUMBLINE ADVISERS | 1,657 | 1,657 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRANDYWINE MANAGERS, LLC | 26,127 | 26,127 | 0 | 0.20 | 0.19 | -0.00 | hold |
| COUNTRY TRUST BANK | 30,186 | 30,186 | 0 | 0.00 | 0.01 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 11,609,704 | 11,609,704 | 0 | 1.01 | 1.22 | +0.21 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,023 | 2,023 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blackstone Inc. | 19,216 | 19,216 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marquette Asset Management, LLC | 27,867 | 27,867 | 0 | 0.03 | 0.03 | +0.01 | hold |
| Alyeska Investment Group, L.P. | 202,148 | 202,148 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 727,673 | 727,673 | 0 | 0.09 | 0.12 | +0.03 | hold |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRV GP IV, LLC | 2,343,154 | 2,343,154 | 0 | 3.92 | 6.43 | +2.51 | hold |
| Steward Partners Investment Advisory, LLC | 790 | 790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PrairieView Partners, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN WEALTH MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.05 | 0.07 | +0.02 | hold |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.02 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,900 | 15,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,485 | 24,485 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 460 | 460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 183,147 | 183,147 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,542 | 1,542 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 1,433,316 | 1,433,316 | 0 | 0.16 | 0.15 | -0.01 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 18,749 | 17,993 | -756 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,247 | 3,658 | -1,589 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 28,356 | 24,821 | -3,535 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 31,010 | 25,830 | -5,180 | 0.01 | 0.01 | +0.00 | sell |
| Simplify Asset Management Inc. | 570,519 | 563,325 | -7,194 | 0.42 | 0.59 | +0.17 | sell |
| Centiva Capital, LP | 10,747 | 0 | -10,747 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 11,845 | 0 | -11,845 | 0.00 | 0.00 | -0.00 | sell |
| DENALI ADVISORS LLC | 70,600 | 57,800 | -12,800 | 0.11 | 0.12 | +0.01 | sell |
| RBF Capital, LLC | 154,100 | 140,000 | -14,100 | 0.05 | 0.06 | +0.01 | sell |
| Verition Fund Management LLC | 19,212 | 0 | -19,212 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 50,000 | 29,370 | -20,630 | 0.08 | 0.08 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 25,424 | 0 | -25,424 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 522,000 | 496,200 | -25,800 | 0.01 | 0.01 | +0.00 | sell |
| XTX Topco Ltd | 38,918 | 0 | -38,918 | 0.03 | 0.00 | -0.03 | sell |
| Bank of New York Mellon Corp | 61,190 | 19,831 | -41,359 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 52,734 | 0 | -52,734 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 58,900 | 0 | -58,900 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 87,372 | 0 | -87,372 | 0.05 | 0.00 | -0.05 | sell |
| Jump Financial, LLC | 91,790 | 0 | -91,790 | 0.02 | 0.00 | -0.02 | sell |
| VANGUARD GROUP INC | 2,643,195 | 2,519,984 | -123,211 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 265,506 | 122,130 | -143,376 | 0.01 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 196,488 | 0 | -196,488 | 0.01 | 0.00 | -0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,718,881 | 5,518,881 | -200,000 | 1.37 | 1.70 | +0.33 | sell |
| FMR LLC | 5,975,416 | 5,684,615 | -290,801 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 562,123 | 261,752 | -300,371 | 0.01 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 5,818,804 | 5,469,956 | -348,848 | 0.55 | 0.58 | +0.03 | sell |
| Vivo Capital, LLC | 520,000 | 0 | -520,000 | 0.25 | 0.00 | -0.25 | sell |
| MARSHALL WACE, LLP | 1,048,646 | 505,102 | -543,544 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,004,682 | 437,503 | -567,179 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,406,422 | 1,506,422 | -900,000 | 0.02 | 0.02 | -0.00 | sell |