| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,229,099 | 10,229,099 | 0 | 0.42 | 0.64 | +0.22 | hold |
| TCG Crossover Management, LLC | 5,250,000 | 5,250,000 | 0 | 1.59 | 2.41 | +0.82 | hold |
| BlackRock, Inc. | 5,706,527 | 5,169,429 | -537,098 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 4,777,912 | 4,779,708 | +1,796 | 1.44 | 1.57 | +0.14 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,182,791 | 3,338,466 | +2,155,675 | 0.15 | 0.58 | +0.43 | buy |
| VANGUARD GROUP INC | 3,274,592 | 3,249,607 | -24,985 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 350,685 | 1,531,732 | +1,181,047 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,423,495 | 1,418,690 | -4,805 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 670,807 | 1,410,520 | +739,713 | 0.02 | 0.04 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,320,862 | 1,294,515 | -26,347 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,680,229 | 1,245,319 | -434,910 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 567,743 | 710,321 | +142,578 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 757,731 | 583,203 | -174,528 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 927,961 | 542,258 | -385,703 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 569,185 | 526,045 | -43,140 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 132,784 | 367,594 | +234,810 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 382,200 | 343,600 | -38,600 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 1,348,793 | 333,323 | -1,015,470 | 0.01 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 289,237 | 301,464 | +12,227 | 0.30 | 0.35 | +0.04 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 285,915 | 285,491 | -424 | 0.00 | 0.00 | +0.00 | sell |
| Exome Asset Management LLC | 0 | 283,599 | +283,599 | 0.00 | 1.00 | +1.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 238,000 | +238,000 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 213,213 | +213,213 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 75,000 | 200,096 | +125,096 | 0.08 | 0.27 | +0.19 | buy |
| ADAR1 Capital Management, LLC | 55,802 | 196,248 | +140,446 | 0.03 | 0.19 | +0.16 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 176,161 | 172,158 | -4,003 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 272,107 | 169,542 | -102,565 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 91,216 | 144,942 | +53,726 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 138,747 | 141,873 | +3,126 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 140,000 | +140,000 | 0.00 | 0.01 | +0.01 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 130,693 | +130,693 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 106,717 | 128,445 | +21,728 | 0.19 | 0.31 | +0.12 | buy |
| BARCLAYS PLC | 124,141 | 122,070 | -2,071 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 113,841 | 120,611 | +6,770 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 23,028 | 118,025 | +94,997 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 23,028 | 118,025 | +94,997 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 112,500 | +112,500 | 0.00 | 0.01 | +0.01 | buy |
| Altium Capital Management LLC | 0 | 111,812 | +111,812 | 0.00 | 0.16 | +0.16 | buy |
| BANK OF AMERICA CORP /DE/ | 99,915 | 91,866 | -8,049 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 91,200 | 91,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 1,724,015 | 90,465 | -1,633,550 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 87,208 | 88,607 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,100 | 86,085 | +62,985 | 0.01 | 0.03 | +0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 84,428 | 83,428 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 351,314 | 80,714 | -270,600 | 0.09 | 0.03 | -0.06 | sell |
| RBF Capital, LLC | 106,128 | 80,506 | -25,622 | 0.02 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 187,163 | 79,120 | -108,043 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 80,633 | 77,392 | -3,241 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 23,495 | 76,123 | +52,628 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 49,015 | 75,959 | +26,944 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 81,735 | 75,140 | -6,595 | 0.03 | 0.04 | +0.01 | sell |
| HRT FINANCIAL LP | 0 | 68,069 | +68,069 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 37,643 | 67,043 | +29,400 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,590 | 65,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MYDA Advisors LLC | 0 | 63,970 | +63,970 | 0.00 | 0.09 | +0.09 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 21,937 | 59,533 | +37,596 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,712 | 52,368 | +16,656 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 74,703 | 49,722 | -24,981 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 98,476 | 45,641 | -52,835 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 227,225 | 45,157 | -182,068 | 0.19 | 0.07 | -0.12 | sell |
| MetLife Investment Management, LLC | 16,315 | 40,107 | +23,792 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 35,900 | +35,900 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 188,961 | 35,707 | -153,254 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,081 | 35,601 | +1,520 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,503 | 34,264 | +8,761 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 39,687 | 34,117 | -5,570 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 33,179 | 30,850 | -2,329 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 17,442 | 30,499 | +13,057 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 33,019 | 30,442 | -2,577 | 0.00 | 0.00 | +0.00 | sell |
| COUNTRY TRUST BANK | 30,186 | 30,186 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 30,662 | 29,976 | -686 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 69,200 | 29,489 | -39,711 | 0.01 | 0.00 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 24,821 | 24,821 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corton Capital Inc. | 57,599 | 23,498 | -34,101 | 0.10 | 0.06 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,774 | 23,470 | -304 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 22,675 | 22,675 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ZACKS INVESTMENT MANAGEMENT | 0 | 20,999 | +20,999 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 20,250 | 20,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANTOR FITZGERALD, L. P. | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 21,671 | 19,888 | -1,783 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 15,410 | 17,475 | +2,065 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 16,516 | +16,516 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 14,262 | 14,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,100 | 13,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WINTON GROUP Ltd | 44,201 | 12,997 | -31,204 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 49,764 | 10,455 | -39,309 | 0.01 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 8,014 | +8,014 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,520 | 6,520 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,079 | 6,079 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PrairieView Partners, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,496 | 4,496 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 28,120 | 3,975 | -24,145 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 0 | 3,936 | +3,936 | 0.00 | 0.01 | +0.01 | buy |
| IFP Advisors, Inc | 901 | 2,294 | +1,393 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,147 | 2,147 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,339 | 1,667 | +328 | 0.00 | 0.00 | +0.00 | buy |