| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,381,000 | 6,561,111 | +1,180,111 | 1.50 | 1.85 | +0.35 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,229,099 | 6,053,960 | -4,175,139 | 1.16 | 0.70 | -0.46 | sell |
| TCG Crossover Management, LLC | 5,250,000 | 5,250,000 | 0 | 2.38 | 1.97 | -0.41 | hold |
| Nantahala Capital Management, LLC | 4,670,784 | 4,293,346 | -377,438 | 2.65 | 2.89 | +0.24 | sell |
| BlackRock, Inc. | 3,706,750 | 4,263,761 | +557,011 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,999,464 | 3,559,552 | +560,088 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 219,488 | 3,061,222 | +2,841,734 | 0.06 | 1.11 | +1.05 | buy |
| Point72 Asset Management, L.P. | 0 | 2,398,232 | +2,398,232 | 0.00 | 0.04 | +0.04 | buy |
| Siren, L.L.C. | 0 | 1,950,000 | +1,950,000 | 0.00 | 0.66 | +0.66 | buy |
| D. E. Shaw & Co., Inc. | 1,449,423 | 1,913,755 | +464,332 | 0.01 | 0.02 | +0.01 | buy |
| First Turn Management, LLC | 0 | 1,892,683 | +1,892,683 | 0.00 | 2.45 | +2.45 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,432,000 | 1,700,000 | -732,000 | 0.04 | 0.03 | -0.01 | sell |
| Ikarian Capital, LLC | 1,289,225 | 1,375,472 | +86,247 | 2.40 | 2.01 | -0.39 | buy |
| Aberdeen Group plc | 137,961 | 1,254,027 | +1,116,066 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 341,612 | 1,253,749 | +912,137 | 0.31 | 1.06 | +0.75 | buy |
| CITADEL ADVISORS LLC | 854,556 | 1,207,004 | +352,448 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,004,051 | 1,105,813 | +101,762 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,299,308 | 1,051,124 | -248,184 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,063,207 | 1,005,345 | -57,862 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,450,480 | 970,439 | -480,041 | 0.03 | 0.02 | -0.01 | sell |
| Vestal Point Capital, LP | 0 | 950,000 | +950,000 | 0.00 | 0.39 | +0.39 | buy |
| GREAT POINT PARTNERS LLC | 0 | 800,000 | +800,000 | 0.00 | 2.93 | +2.93 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 540,641 | 736,740 | +196,099 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 384,138 | 582,377 | +198,239 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 568,322 | 552,220 | -16,102 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 678,414 | 517,526 | -160,888 | 0.16 | 0.15 | -0.01 | sell |
| JANE STREET GROUP, LLC | 321,520 | 493,750 | +172,230 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 123,872 | 417,189 | +293,317 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 394,650 | +394,650 | 0.00 | 0.65 | +0.65 | buy |
| Qube Research & Technologies Ltd | 0 | 392,489 | +392,489 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333,483 | 388,896 | +55,413 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 382,000 | +382,000 | 0.00 | 0.72 | +0.72 | buy |
| Trexquant Investment LP | 21,015 | 355,547 | +334,532 | 0.00 | 0.04 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 586,351 | 323,879 | -262,472 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 285,329 | 287,096 | +1,767 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 286,988 | 286,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 243,388 | +243,388 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 147,211 | 231,177 | +83,966 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 201,301 | +201,301 | 0.00 | 0.40 | +0.40 | buy |
| Nicholas Investment Partners, LP | 0 | 182,961 | +182,961 | 0.00 | 0.15 | +0.15 | buy |
| WELLS FARGO & COMPANY/MN | 32,507 | 166,395 | +133,888 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 243,835 | 165,623 | -78,212 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 83,234 | 159,674 | +76,440 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 152,244 | 157,672 | +5,428 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 179,358 | 146,427 | -32,931 | 0.00 | 0.00 | +0.00 | sell |
| SummitTX Capital, L.P. | 0 | 138,143 | +138,143 | 0.00 | 0.05 | +0.05 | buy |
| FIDUCIARY TRUST CO | 136,555 | 136,555 | 0 | 0.01 | 0.02 | +0.00 | hold |
| BARCLAYS PLC | 89,616 | 132,541 | +42,925 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 119,158 | 116,906 | -2,252 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 112,203 | 112,203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Capital LLC | 0 | 108,434 | +108,434 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 301,157 | 102,967 | -198,190 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 102,921 | +102,921 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 124,666 | 100,675 | -23,991 | 0.00 | 0.00 | -0.00 | sell |
| Maven Securities LTD | 0 | 100,000 | +100,000 | 0.00 | 0.14 | +0.14 | buy |
| GSA CAPITAL PARTNERS LLP | 116,068 | 99,709 | -16,359 | 0.09 | 0.10 | +0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 66,550 | 97,688 | +31,138 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 92,200 | +92,200 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 98,799 | 92,055 | -6,744 | 0.60 | 0.51 | -0.09 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,571 | 87,930 | +34,359 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,666 | 86,499 | +72,833 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 80,506 | 80,506 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Verition Fund Management LLC | 0 | 74,691 | +74,691 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 72,060 | +72,060 | 0.00 | 0.44 | +0.44 | buy |
| CITIGROUP INC | 718 | 67,102 | +66,384 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,272 | 66,716 | +55,444 | 0.00 | 0.02 | +0.01 | buy |
| Legato Capital Management LLC | 0 | 66,347 | +66,347 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 17,826 | 65,852 | +48,026 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 65,892 | 63,760 | -2,132 | 0.00 | 0.00 | +0.00 | sell |
| Integrated Quantitative Investments LLC | 0 | 62,522 | +62,522 | 0.00 | 0.15 | +0.15 | buy |
| Informed Momentum Co LLC | 0 | 61,620 | +61,620 | 0.00 | 0.08 | +0.08 | buy |
| Atom Investors LP | 0 | 60,595 | +60,595 | 0.00 | 0.05 | +0.05 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,100 | 57,725 | +44,625 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 69,372 | 55,713 | -13,659 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 150,867 | 54,431 | -96,436 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 51,802 | +51,802 | 0.00 | 0.02 | +0.02 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| STRS OHIO | 77,900 | 49,300 | -28,600 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 15,303 | 48,900 | +33,597 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 30,486 | 48,464 | +17,978 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 60,022 | 44,249 | -15,773 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 53,806 | 43,262 | -10,544 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 41,260 | +41,260 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 83,428 | 40,000 | -43,428 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 0 | 37,511 | +37,511 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 102,470 | 35,601 | -66,869 | 0.07 | 0.02 | -0.05 | sell |
| GROUP ONE TRADING LLC | 5,760 | 34,750 | +28,990 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 31,545 | +31,545 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 0 | 30,793 | +30,793 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 31,500 | 30,500 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| COUNTRY TRUST BANK | 30,041 | 30,041 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LMR Partners LLP | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantinno Capital Management LP | 24,649 | 29,264 | +4,615 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,832 | 28,832 | 0 | 0.02 | 0.02 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 50,791 | 25,568 | -25,223 | 0.07 | 0.04 | -0.03 | sell |
| MetLife Investment Management, LLC | 25,895 | 22,714 | -3,181 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 14,354 | 22,104 | +7,750 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 18,069 | 20,789 | +2,720 | 0.00 | 0.00 | +0.00 | buy |