| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 1,401,938 | +1,401,938 | 0.00 | 0.80 | +0.80 | buy |
| FMR LLC | 1,516,335 | 2,799,400 | +1,283,065 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 0 | 398,885 | +398,885 | 0.00 | 2.32 | +2.32 | buy |
| Bollard Group LLC | 0 | 302,953 | +302,953 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 28,793 | 237,938 | +209,145 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 0 | 187,500 | +187,500 | 0.00 | 1.06 | +1.06 | buy |
| Woodline Partners LP | 130,109 | 302,215 | +172,106 | 0.04 | 0.03 | -0.01 | buy |
| MORGAN STANLEY | 0 | 164,235 | +164,235 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 713,050 | 853,050 | +140,000 | 0.17 | 0.08 | -0.09 | buy |
| Ally Bridge Group (NY) LLC | 0 | 132,222 | +132,222 | 0.00 | 2.11 | +2.11 | buy |
| Ikarian Capital, LLC | 142,328 | 269,090 | +126,762 | 1.88 | 1.55 | -0.32 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 79,166 | 179,166 | +100,000 | 0.24 | 0.18 | -0.07 | buy |
| BAKER BROS. ADVISORS LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 48,173 | 144,302 | +96,129 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 93,474 | +93,474 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 849,143 | 935,121 | +85,978 | 1.57 | 0.98 | -0.58 | buy |
| GOLDMAN SACHS GROUP INC | 24,310 | 104,793 | +80,483 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 65,701 | +65,701 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 53,340 | +53,340 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 52,897 | +52,897 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 50,746 | +50,746 | 0.00 | 1.07 | +1.07 | buy |
| Soleus Capital Management, L.P. | 31,841 | 76,841 | +45,000 | 0.11 | 0.11 | -0.00 | buy |
| Windmill Hill Asset Management Ltd | 0 | 40,023 | +40,023 | 0.00 | 0.22 | +0.22 | buy |
| Knott David M Jr | 0 | 40,000 | +40,000 | 0.00 | 0.33 | +0.33 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,307 | 79,469 | +38,162 | 0.06 | 0.05 | -0.01 | buy |
| OAKMONT Corp | 0 | 25,115 | +25,115 | 0.00 | 0.09 | +0.09 | buy |
| Jump Financial, LLC | 0 | 21,126 | +21,126 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 14,485 | 34,645 | +20,160 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 19,660 | +19,660 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 0 | 18,461 | +18,461 | 0.00 | 0.28 | +0.28 | buy |
| JANE STREET GROUP, LLC | 29,702 | 47,145 | +17,443 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 29,757 | 47,105 | +17,348 | 0.00 | 0.00 | -0.00 | buy |
| Cliffwater LLC | 0 | 15,369 | +15,369 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 18,513 | 32,771 | +14,258 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 4,939 | 18,735 | +13,796 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,212 | +13,212 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,807 | +12,807 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,057 | +12,057 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 195,059 | 205,528 | +10,469 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 26,264 | 32,161 | +5,897 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 58,708 | 62,603 | +3,895 | 0.56 | 0.21 | -0.35 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,541 | +3,541 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 27,405 | 30,805 | +3,400 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 169 | 2,596 | +2,427 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 77,584 | 79,487 | +1,903 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 216 | 833 | +617 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 369 | +369 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 283 | +283 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 232 | +232 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 361,048 | 361,168 | +120 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 310 | 377 | +67 | 0.00 | 0.00 | -0.00 | buy |
| Caldwell Trust Co | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 492 | 500 | +8 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 14,668 | 14,668 | 0 | 0.02 | 0.01 | -0.01 | hold |
| RHUMBLINE ADVISERS | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clarius Group, LLC | 10,130 | 10,130 | 0 | 0.03 | 0.01 | -0.02 | hold |
| SBI Securities Co., Ltd. | 87 | 87 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nordwand Advisors, LLC | 1,500 | 1,500 | 0 | 0.03 | 0.01 | -0.02 | hold |
| NORTHERN TRUST CORP | 14,682 | 14,682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 39 | 39 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 69 | 45 | -24 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 531 | 365 | -166 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,128 | 2,959 | -169 | 0.01 | 0.00 | -0.01 | sell |
| Aldebaran Capital, LLC | 41,207 | 40,896 | -311 | 1.81 | 0.69 | -1.12 | sell |
| JPMORGAN CHASE & CO | 1,244 | 0 | -1,244 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,533 | 0 | -1,533 | 0.03 | 0.00 | -0.03 | sell |
| BARCLAYS PLC | 15,974 | 13,710 | -2,264 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 3,833 | 1,500 | -2,333 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 17,345 | 14,296 | -3,049 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,711 | 0 | -4,711 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 5,000 | 0 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 5,400 | 0 | -5,400 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 6,768 | 0 | -6,768 | 0.12 | 0.00 | -0.12 | sell |
| AMERIPRISE FINANCIAL INC | 7,516 | 0 | -7,516 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 7,841 | 0 | -7,841 | 0.03 | 0.00 | -0.03 | sell |
| STEMPOINT CAPITAL LP | 9,434 | 0 | -9,434 | 0.11 | 0.00 | -0.11 | sell |
| OMERS ADMINISTRATION Corp | 9,600 | 0 | -9,600 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 10,057 | 0 | -10,057 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 10,774 | 0 | -10,774 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,583 | 648 | -12,935 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 14,027 | 0 | -14,027 | 0.06 | 0.00 | -0.06 | sell |
| Artia Global Partners LP | 16,650 | 0 | -16,650 | 0.31 | 0.00 | -0.31 | sell |
| Informed Momentum Co LLC | 25,061 | 0 | -25,061 | 0.16 | 0.00 | -0.16 | sell |
| Exome Asset Management LLC | 26,081 | 0 | -26,081 | 0.91 | 0.00 | -0.91 | sell |
| Verition Fund Management LLC | 26,171 | 0 | -26,171 | 0.01 | 0.00 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 33,008 | 0 | -33,008 | 1.53 | 0.00 | -1.53 | sell |
| Affinity Asset Advisors, LLC | 58,331 | 0 | -58,331 | 0.42 | 0.00 | -0.42 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,452 | 106,703 | -59,749 | 0.01 | 0.00 | -0.01 | sell |
| Walleye Capital LLC | 73,517 | 0 | -73,517 | 0.03 | 0.00 | -0.03 | sell |
| Atlas Venture Life Science Advisors, LLC | 78,447 | 0 | -78,447 | 0.44 | 0.00 | -0.44 | sell |
| 5AM Venture Management, LLC | 596,660 | 511,660 | -85,000 | 6.57 | 3.43 | -3.15 | sell |
| Invesco Ltd. | 128,178 | 0 | -128,178 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 247,000 | 10,192 | -236,808 | 0.03 | 0.00 | -0.03 | sell |
| Paradigm Biocapital Advisors LP | 485,105 | 0 | -485,105 | 0.78 | 0.00 | -0.78 | sell |
| Vida Ventures Advisors, LLC | 1,028,674 | 0 | -1,028,674 | 32.46 | 0.00 | -32.46 | sell |