| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,807,442 | 2,816,494 | +9,052 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 1,204,891 | +1,204,891 | 0.00 | 1.07 | +1.07 | buy |
| Aberdeen Group plc | 1,141,824 | 1,141,824 | 0 | 0.04 | 0.06 | +0.02 | hold |
| BlackRock, Inc. | 854,363 | 860,352 | +5,989 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 927,524 | 847,151 | -80,373 | 0.62 | 0.87 | +0.25 | sell |
| First Light Asset Management, LLC | 0 | 647,743 | +647,743 | 0.00 | 1.79 | +1.79 | buy |
| BAKER BROS. ADVISORS LP | 903,400 | 607,788 | -295,612 | 0.11 | 0.11 | -0.00 | sell |
| 5AM Venture Management, LLC | 606,660 | 606,660 | 0 | 3.98 | 5.21 | +1.23 | hold |
| Vestal Point Capital, LP | 328,000 | 328,000 | 0 | 0.25 | 0.28 | +0.03 | hold |
| Bollard Group LLC | 302,953 | 302,953 | 0 | 0.17 | 0.29 | +0.12 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 209,225 | 286,682 | +77,457 | 0.09 | 0.19 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 263,560 | 268,273 | +4,713 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 30,918 | 229,595 | +198,677 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 574,600 | 226,600 | -348,000 | 0.25 | 0.15 | -0.09 | sell |
| STATE STREET CORP | 209,125 | 213,505 | +4,380 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 199,646 | 164,419 | -35,227 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 164,055 | +164,055 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 157,537 | +157,537 | 0.00 | 0.70 | +0.70 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 143,432 | +143,432 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 214,747 | 123,000 | -91,747 | 0.59 | 0.50 | -0.09 | sell |
| Soleus Capital Management, L.P. | 0 | 121,684 | +121,684 | 0.00 | 0.15 | +0.15 | buy |
| D. E. Shaw & Co., Inc. | 120,250 | 116,120 | -4,130 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 120,411 | 112,664 | -7,747 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 200,000 | 100,000 | -100,000 | 0.02 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 111,188 | 83,679 | -27,509 | 0.03 | 0.03 | -0.00 | sell |
| Prosight Management, LP | 235,000 | 79,872 | -155,128 | 1.01 | 0.40 | -0.61 | sell |
| NORTHERN TRUST CORP | 72,255 | 78,353 | +6,098 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 492,332 | 68,598 | -423,734 | 0.02 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 71,657 | 66,994 | -4,663 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 94,435 | 64,848 | -29,587 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 54,601 | 64,196 | +9,595 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 92,703 | 62,426 | -30,277 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 5,779 | 58,870 | +53,091 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 300,820 | 58,348 | -242,472 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 46,137 | +46,137 | 0.00 | 0.03 | +0.03 | buy |
| PFM Health Sciences, LP | 42,724 | 46,129 | +3,405 | 0.09 | 0.15 | +0.06 | buy |
| Jump Financial, LLC | 39,500 | 43,098 | +3,598 | 0.01 | 0.02 | +0.01 | buy |
| TFG Asset Management GP Ltd | 0 | 37,588 | +37,588 | 0.00 | 0.23 | +0.23 | buy |
| Aldebaran Capital, LLC | 37,353 | 37,184 | -169 | 0.70 | 0.88 | +0.18 | sell |
| SEI INVESTMENTS CO | 15,251 | 36,870 | +21,619 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 31,215 | 29,987 | -1,228 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 37,379 | 29,240 | -8,139 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,461 | 29,110 | -3,351 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Advisors, LLC | 6,500 | 26,760 | +20,260 | 0.00 | 0.01 | +0.01 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 26,594 | 26,753 | +159 | 0.37 | 0.23 | -0.14 | buy |
| Bank of New York Mellon Corp | 25,858 | 24,760 | -1,098 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 20,400 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 42,255 | 19,059 | -23,196 | 0.71 | 0.52 | -0.19 | sell |
| GSA CAPITAL PARTNERS LLP | 63,276 | 18,873 | -44,403 | 0.11 | 0.04 | -0.08 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 16,934 | +16,934 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,713 | 16,175 | -135,538 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 15,369 | 15,286 | -83 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 14,196 | 14,027 | -169 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 13,929 | +13,929 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 13,462 | 13,799 | +337 | 0.08 | 0.12 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 30,007 | 13,001 | -17,006 | 0.05 | 0.02 | -0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,534 | +12,534 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 12,446 | +12,446 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 14,304 | 12,033 | -2,271 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 0 | 11,621 | +11,621 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 10,075 | 10,077 | +2 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 7,589 | 9,345 | +1,756 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 7,675 | +7,675 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,724 | 6,724 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 22,443 | 6,706 | -15,737 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,050 | 6,332 | +282 | 0.01 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,079 | 5,215 | +136 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,000 | 4,600 | -400 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,819 | 2,816 | -3 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 2,638 | 2,638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 466 | 1,829 | +1,363 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 1,449 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 9,142 | 1,351 | -7,791 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1,033 | 1,147 | +114 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 37 | 1,136 | +1,099 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,122 | 1,122 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,050 | 1,000 | -50 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 909 | 979 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 752 | 914 | +162 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 929 | 851 | -78 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 676 | 595 | -81 | 0.00 | 0.00 | +0.00 | sell |
| HighMark Wealth Management LLC | 587 | 587 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 367 | 415 | +48 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 173 | 382 | +209 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 370 | +370 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 29 | 330 | +301 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 537 | 313 | -224 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 373 | 102 | -271 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 62 | 65 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Marshall & Sterling Wealth Advisors Inc. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Caldwell Trust Co | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 2 | 19 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Global Wealth Strategies & Associates | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 5 | 8 | +3 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |