| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 1,077,538 | +1,077,538 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 849,143 | +849,143 | 0.00 | 0.43 | +0.43 | buy |
| 5AM Venture Management, LLC | 0 | 646,524 | +646,524 | 0.00 | 2.38 | +2.38 | buy |
| BML Capital Management, LLC | 0 | 466,047 | +466,047 | 0.00 | 5.62 | +5.62 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 431,010 | +431,010 | 0.00 | 0.04 | +0.04 | buy |
| Atlas Venture Life Science Advisors, LLC | 0 | 378,447 | +378,447 | 0.00 | 0.66 | +0.66 | buy |
| ADAR1 Capital Management, LLC | 0 | 356,878 | +356,878 | 0.00 | 1.18 | +1.18 | buy |
| VANGUARD GROUP INC | 0 | 156,768 | +156,768 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 140,680 | +140,680 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 109,629 | +109,629 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 89,029 | +89,029 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 0 | 84,148 | +84,148 | 0.00 | 0.60 | +0.60 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 79,166 | +79,166 | 0.00 | 0.13 | +0.13 | buy |
| Prosight Management, LP | 0 | 67,461 | +67,461 | 0.00 | 0.33 | +0.33 | buy |
| Ikarian Capital, LLC | 0 | 62,836 | +62,836 | 0.00 | 0.32 | +0.32 | buy |
| Affinity Asset Advisors, LLC | 0 | 58,331 | +58,331 | 0.00 | 0.15 | +0.15 | buy |
| Aldebaran Capital, LLC | 0 | 41,991 | +41,991 | 0.00 | 0.64 | +0.64 | buy |
| Exome Asset Management LLC | 0 | 32,389 | +32,389 | 0.00 | 0.47 | +0.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 31,033 | +31,033 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 23,984 | +23,984 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 19,781 | +19,781 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 15,885 | +15,885 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,545 | +14,545 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 13,071 | +13,071 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 11,677 | +11,677 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 9,725 | +9,725 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 8,140 | +8,140 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 3,376 | +3,376 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 0 | 1,441 | +1,441 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 249 | +249 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |