| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,816,494 | 2,830,378 | +13,884 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 1,204,891 | 1,204,891 | 0 | 1.07 | 1.00 | -0.07 | hold |
| Aberdeen Group plc | 1,141,824 | 1,141,824 | 0 | 0.06 | 0.06 | -0.00 | hold |
| BlackRock, Inc. | 860,352 | 862,592 | +2,240 | 0.00 | 0.00 | -0.00 | buy |
| First Light Asset Management, LLC | 647,743 | 800,726 | +152,983 | 1.79 | 1.67 | -0.12 | buy |
| BAKER BROS. ADVISORS LP | 607,788 | 607,788 | 0 | 0.11 | 0.10 | -0.00 | hold |
| 5AM Venture Management, LLC | 606,660 | 606,660 | 0 | 5.21 | 7.24 | +2.04 | hold |
| BRAIDWELL LP | 847,151 | 596,900 | -250,251 | 0.87 | 0.76 | -0.11 | sell |
| Vestal Point Capital, LP | 328,000 | 425,000 | +97,000 | 0.28 | 0.34 | +0.06 | buy |
| Bollard Group LLC | 302,953 | 302,953 | 0 | 0.29 | 0.32 | +0.03 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 286,682 | 282,202 | -4,480 | 0.19 | 0.17 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 268,273 | 270,461 | +2,188 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 226,600 | 226,600 | 0 | 0.15 | 0.15 | -0.01 | hold |
| STATE STREET CORP | 213,505 | 219,908 | +6,403 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 157,537 | 205,837 | +48,300 | 0.70 | 1.16 | +0.46 | buy |
| D. E. Shaw & Co., Inc. | 116,120 | 186,550 | +70,430 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 229,595 | 172,101 | -57,494 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 58,348 | 165,525 | +107,177 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 164,419 | 145,028 | -19,391 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 143,432 | 142,448 | -984 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 112,664 | 117,428 | +4,764 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 78,353 | 113,904 | +35,551 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 121,684 | 101,684 | -20,000 | 0.15 | 0.12 | -0.03 | sell |
| Woodline Partners LP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CITADEL ADVISORS LLC | 0 | 90,393 | +90,393 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 62,426 | 73,924 | +11,498 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 64,196 | 72,674 | +8,478 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 19,059 | 71,009 | +51,950 | 0.52 | 1.70 | +1.18 | buy |
| JANE STREET GROUP, LLC | 0 | 65,821 | +65,821 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 64,848 | 65,373 | +525 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 66,994 | 64,940 | -2,054 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 46,137 | 60,771 | +14,634 | 0.03 | 0.04 | +0.01 | buy |
| JPMORGAN CHASE & CO | 58,870 | 55,364 | -3,506 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 164,055 | 48,001 | -116,054 | 0.00 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 37,588 | 46,516 | +8,928 | 0.23 | 0.26 | +0.03 | buy |
| PFM Health Sciences, LP | 46,129 | 45,631 | -498 | 0.15 | 0.14 | -0.01 | sell |
| HRT FINANCIAL LP | 0 | 44,540 | +44,540 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 43,098 | 43,400 | +302 | 0.02 | 0.01 | -0.01 | buy |
| Prosight Management, LP | 79,872 | 39,731 | -40,141 | 0.40 | 0.24 | -0.17 | sell |
| Trexquant Investment LP | 0 | 36,991 | +36,991 | 0.00 | 0.01 | +0.01 | buy |
| Aldebaran Capital, LLC | 37,184 | 36,797 | -387 | 0.88 | 0.95 | +0.07 | sell |
| ExodusPoint Capital Management, LP | 83,679 | 35,239 | -48,440 | 0.03 | 0.01 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 29,240 | 31,432 | +2,192 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 30,438 | +30,438 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,110 | 30,438 | +1,328 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 26,753 | 28,143 | +1,390 | 0.23 | 0.25 | +0.02 | buy |
| Bank of New York Mellon Corp | 24,760 | 25,247 | +487 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 15,286 | 19,147 | +3,861 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 19,122 | +19,122 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,534 | 19,001 | +6,467 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 18,067 | +18,067 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 36,870 | 17,029 | -19,841 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 26,760 | 16,630 | -10,130 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 29,987 | 15,055 | -14,932 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 13,001 | 14,501 | +1,500 | 0.02 | 0.02 | -0.00 | buy |
| RHUMBLINE ADVISERS | 14,027 | 13,773 | -254 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 12,033 | 13,514 | +1,481 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 13,799 | 10,806 | -2,993 | 0.12 | 0.09 | -0.03 | sell |
| DIMENSIONAL FUND ADVISORS LP | 10,077 | 10,443 | +366 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 9,345 | 10,039 | +694 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 9,573 | +9,573 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 6,706 | 9,128 | +2,422 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,446 | 8,961 | -3,485 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 8,865 | +8,865 | 0.00 | 0.05 | +0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 18,873 | 8,275 | -10,598 | 0.04 | 0.02 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 7,460 | +7,460 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,724 | 6,724 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 16,934 | 6,617 | -10,317 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 7,675 | 6,388 | -1,287 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 6,060 | +6,060 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.19 | +0.19 | buy |
| Velan Capital Investment Management LP | 0 | 6,000 | +6,000 | 0.00 | 0.13 | +0.13 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,929 | 5,996 | -7,933 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 851 | 5,548 | +4,697 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,147 | 5,548 | +4,401 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,332 | 5,503 | -829 | 0.01 | 0.01 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 5,000 | 5,400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,816 | 5,146 | +2,330 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,215 | 4,694 | -521 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,600 | 4,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,638 | 2,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantbot Technologies LP | 0 | 1,819 | +1,819 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 1,191 | +1,191 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,122 | 1,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 1,136 | 1,080 | -56 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 979 | 844 | -135 | 0.00 | 0.00 | -0.00 | sell |
| Chung Wu Investment Group, LLC | 0 | 800 | +800 | 0.00 | 0.02 | +0.02 | buy |
| Arax Advisory Partners | 0 | 725 | +725 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 914 | 661 | -253 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 0 | 601 | +601 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 587 | 587 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 1,351 | 439 | -912 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 415 | 400 | -15 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 382 | 382 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 370 | 370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 330 | 290 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 500 | 250 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 313 | 176 | -137 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 595 | 141 | -454 | 0.00 | 0.00 | -0.00 | sell |