| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vida Ventures Advisors, LLC | 0 | 1,028,674 | +1,028,674 | 0.00 | 22.49 | +22.49 | buy |
| VANGUARD GROUP INC | 156,768 | 442,814 | +286,046 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 62,836 | 267,145 | +204,309 | 0.32 | 2.51 | +2.19 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 180,473 | +180,473 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 1,077,538 | 1,220,138 | +142,600 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 431,010 | 520,397 | +89,387 | 0.04 | 0.09 | +0.04 | buy |
| Prosight Management, LP | 67,461 | 137,614 | +70,153 | 0.33 | 1.06 | +0.73 | buy |
| Woodline Partners LP | 0 | 65,448 | +65,448 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 62,754 | +62,754 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 15,885 | 75,644 | +59,759 | 0.01 | 0.07 | +0.06 | buy |
| Walleye Capital LLC | 23,984 | 72,962 | +48,978 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 31,033 | 76,879 | +45,846 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 26,191 | +26,191 | 0.00 | 0.12 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 23,855 | +23,855 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 13,700 | +13,700 | 0.00 | 0.34 | +0.34 | buy |
| CITIGROUP INC | 0 | 11,800 | +11,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,725 | 20,952 | +11,227 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 9,645 | +9,645 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 7,841 | +7,841 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 7,702 | +7,702 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 32,389 | 36,344 | +3,955 | 0.47 | 0.74 | +0.27 | buy |
| Nordwand Advisors, LLC | 0 | 1,500 | +1,500 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 19,781 | 20,381 | +600 | 0.01 | 0.01 | +0.01 | buy |
| CWM, LLC | 0 | 531 | +531 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 79,166 | 79,166 | 0 | 0.13 | 0.17 | +0.04 | hold |
| Aldebaran Capital, LLC | 41,991 | 41,991 | 0 | 0.64 | 1.16 | +0.52 | hold |
| EcoR1 Capital, LLC | 849,143 | 849,143 | 0 | 0.43 | 0.88 | +0.45 | hold |
| Aisling Capital Management LP | 84,148 | 84,148 | 0 | 0.60 | 0.98 | +0.38 | hold |
| Affinity Asset Advisors, LLC | 58,331 | 58,331 | 0 | 0.15 | 0.27 | +0.12 | hold |
| 5AM Venture Management, LLC | 646,524 | 646,524 | 0 | 2.38 | 4.05 | +1.67 | hold |
| Atlas Venture Life Science Advisors, LLC | 378,447 | 378,447 | 0 | 0.66 | 1.06 | +0.41 | hold |
| BARCLAYS PLC | 1,441 | 1,441 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 31 | 31 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 11,677 | 11,677 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 249 | 0 | -249 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 3,376 | 0 | -3,376 | 0.04 | 0.00 | -0.04 | sell |
| TWO SIGMA INVESTMENTS, LP | 14,545 | 11,031 | -3,514 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Advisors, LLC | 8,140 | 3,916 | -4,224 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 13,071 | 0 | -13,071 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 140,680 | 114,778 | -25,902 | 0.02 | 0.02 | +0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 89,029 | 56,897 | -32,132 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 109,629 | 9,395 | -100,234 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 356,878 | 127,159 | -229,719 | 1.18 | 0.65 | -0.54 | sell |
| BML Capital Management, LLC | 466,047 | 211,752 | -254,295 | 5.62 | 3.78 | -1.85 | sell |