| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,800,876 | 2,806,781 | +5,905 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 761,297 | 827,853 | +66,556 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 0 | 736,867 | +736,867 | 0.00 | 0.34 | +0.34 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 853,050 | 640,000 | -213,050 | 0.08 | 0.06 | -0.02 | sell |
| VANGUARD GROUP INC | 584,393 | 569,480 | -14,913 | 0.00 | 0.00 | -0.00 | sell |
| 5AM Venture Management, LLC | 511,660 | 511,660 | 0 | 3.91 | 2.94 | -0.97 | hold |
| Point72 Asset Management, L.P. | 231,032 | 421,755 | +190,723 | 0.01 | 0.01 | +0.00 | buy |
| Prosight Management, LP | 442,056 | 379,254 | -62,802 | 2.14 | 1.43 | -0.71 | sell |
| Aberdeen Group plc | 0 | 356,176 | +356,176 | 0.00 | 0.01 | +0.01 | buy |
| Bollard Group LLC | 302,953 | 302,953 | 0 | 0.14 | 0.12 | -0.02 | hold |
| CITADEL ADVISORS LLC | 165,046 | 298,388 | +133,342 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 272,257 | 269,353 | -2,904 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 0 | 259,726 | +259,726 | 0.00 | 0.45 | +0.45 | buy |
| TFG Asset Management GP Ltd | 228,832 | 243,728 | +14,896 | 0.82 | 0.56 | -0.26 | buy |
| MILLENNIUM MANAGEMENT LLC | 74,889 | 238,170 | +163,281 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 208,776 | +208,776 | 0.00 | 0.07 | +0.07 | buy |
| First Light Asset Management, LLC | 0 | 202,393 | +202,393 | 0.00 | 0.30 | +0.30 | buy |
| Woodline Partners LP | 321,637 | 200,000 | -121,637 | 0.03 | 0.01 | -0.02 | sell |
| SECTORAL ASSET MANAGEMENT INC | 98,970 | 192,770 | +93,800 | 1.30 | 1.87 | +0.57 | buy |
| STEMPOINT CAPITAL LP | 40,000 | 188,999 | +148,999 | 0.26 | 0.60 | +0.34 | buy |
| TANG CAPITAL MANAGEMENT LLC | 179,166 | 179,166 | 0 | 0.18 | 0.11 | -0.07 | hold |
| STATE STREET CORP | 131,041 | 165,531 | +34,490 | 0.00 | 0.00 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 163,683 | 138,595 | -25,088 | 2.71 | 1.82 | -0.89 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 79,058 | 119,286 | +40,228 | 1.96 | 1.84 | -0.11 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 115,908 | +115,908 | 0.00 | 0.43 | +0.43 | buy |
| MORGAN STANLEY | 160,430 | 104,733 | -55,697 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 72,772 | 102,473 | +29,701 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 100,000 | 100,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 0 | 96,866 | +96,866 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 86,987 | 93,400 | +6,413 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 79,074 | 83,231 | +4,157 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 74,000 | 74,000 | 0 | 0.67 | 0.49 | -0.18 | hold |
| Jain Global LLC | 0 | 71,504 | +71,504 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 34,238 | 66,460 | +32,222 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 85,369 | 65,435 | -19,934 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 73,505 | 56,007 | -17,498 | 0.24 | 0.09 | -0.15 | sell |
| RAYMOND JAMES FINANCIAL INC | 21,544 | 51,931 | +30,387 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 35,708 | 43,885 | +8,177 | 0.00 | 0.00 | -0.00 | buy |
| Windmill Hill Asset Management Ltd | 40,023 | 40,023 | 0 | 0.22 | 0.16 | -0.05 | hold |
| Aldebaran Capital, LLC | 40,258 | 38,502 | -1,756 | 0.79 | 0.55 | -0.23 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 28,545 | 37,362 | +8,817 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,365 | 32,358 | -7 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 28,720 | +28,720 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 26,272 | +26,272 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 25,258 | 26,133 | +875 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 10,678 | 25,076 | +14,398 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 76,841 | 25,000 | -51,841 | 0.11 | 0.02 | -0.08 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 23,894 | 23,894 | 0 | 0.38 | 0.28 | -0.10 | hold |
| BARCLAYS PLC | 21,891 | 17,976 | -3,915 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 15,975 | 15,993 | +18 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 15,559 | +15,559 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 14,304 | 14,304 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 13,017 | +13,017 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.18 | +0.18 | buy |
| Engineers Gate Manager LP | 0 | 11,093 | +11,093 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,856 | +10,856 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 10,662 | +10,662 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 10,130 | 10,130 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AlphaQuest LLC | 2,365 | 7,299 | +4,934 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,750 | 6,880 | +3,130 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,724 | 6,724 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 6,548 | 5,924 | -624 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,012 | 5,134 | -878 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 4,190 | 5,071 | +881 | 0.03 | 0.02 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,000 | 5,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 719 | 3,966 | +3,247 | 0.01 | 0.04 | +0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,638 | 2,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 16,314 | 2,422 | -13,892 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,247 | 1,465 | +218 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 4,079 | 1,158 | -2,921 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,122 | 1,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 1,103 | +1,103 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,050 | 1,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 910 | +910 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 768 | +768 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 721 | 723 | +2 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 684 | +684 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 251 | 633 | +382 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 377 | 403 | +26 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 365 | 384 | +19 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 375 | 375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 283 | 164 | -119 | 0.00 | 0.00 | -0.00 | sell |
| Vermillion & White Wealth Management Group, LLC | 107 | 107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 37 | 37 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rise Advisors, LLC | 28 | 28 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caldwell Trust Co | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Wealth Strategies & Associates | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 39 | 8 | -31 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,383 | 0 | -12,383 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,707 | 0 | -18,707 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 45,077 | 0 | -45,077 | 0.03 | 0.00 | -0.03 | sell |
| Allworth Financial LP | 26 | 0 | -26 | 0.00 | 0.00 | -0.00 | sell |