| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 485,105 | +485,105 | 0.00 | 0.78 | +0.78 | buy |
| FMR LLC | 1,220,138 | 1,516,335 | +296,197 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 520,397 | 713,050 | +192,653 | 0.09 | 0.17 | +0.09 | buy |
| Invesco Ltd. | 0 | 128,178 | +128,178 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,754 | 166,452 | +103,698 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 123,032 | 195,059 | +72,027 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 180,473 | 247,000 | +66,527 | 0.01 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 65,448 | 130,109 | +64,661 | 0.02 | 0.04 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 31,841 | +31,841 | 0.00 | 0.11 | +0.11 | buy |
| Qube Research & Technologies Ltd | 0 | 29,757 | +29,757 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 29,702 | +29,702 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 28,793 | +28,793 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 24,310 | +24,310 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 13,700 | 33,008 | +19,308 | 0.34 | 1.53 | +1.20 | buy |
| Artia Global Partners LP | 0 | 16,650 | +16,650 | 0.00 | 0.31 | +0.31 | buy |
| STATE STREET CORP | 11,677 | 27,405 | +15,728 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,441 | 15,974 | +14,533 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 14,027 | +14,027 | 0.00 | 0.06 | +0.06 | buy |
| UBS Group AG | 0 | 10,774 | +10,774 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 0 | 10,130 | +10,130 | 0.00 | 0.03 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 10,057 | +10,057 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 9,600 | +9,600 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 9,434 | +9,434 | 0.00 | 0.11 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 7,516 | +7,516 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 7,702 | 14,485 | +6,783 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 9,645 | 14,682 | +5,037 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 4,711 | +4,711 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,128 | +3,128 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,855 | 26,264 | +2,409 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 15,000 | 17,345 | +2,345 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 11,800 | 13,583 | +1,783 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 1,533 | +1,533 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 0 | 1,244 | +1,244 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 76,879 | 77,584 | +705 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 72,962 | 73,517 | +555 | 0.02 | 0.03 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 216 | +216 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 169 | +169 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 32 | 69 | +37 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 31 | 39 | +8 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 79,166 | 79,166 | 0 | 0.17 | 0.24 | +0.07 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 7,841 | 7,841 | 0 | 0.02 | 0.03 | +0.01 | hold |
| CWM, LLC | 531 | 531 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 849,143 | 849,143 | 0 | 0.88 | 1.57 | +0.68 | hold |
| Affinity Asset Advisors, LLC | 58,331 | 58,331 | 0 | 0.27 | 0.42 | +0.15 | hold |
| Vida Ventures Advisors, LLC | 1,028,674 | 1,028,674 | 0 | 22.49 | 32.46 | +9.97 | hold |
| Nordwand Advisors, LLC | 1,500 | 1,500 | 0 | 0.01 | 0.03 | +0.02 | hold |
| Aster Capital Management (DIFC) Ltd | 6,768 | 6,768 | 0 | 0.04 | 0.12 | +0.07 | hold |
| GROUP ONE TRADING LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 3,916 | 3,833 | -83 | 0.00 | 0.00 | +0.00 | sell |
| Aldebaran Capital, LLC | 41,991 | 41,207 | -784 | 1.16 | 1.81 | +0.65 | sell |
| Informed Momentum Co LLC | 26,191 | 25,061 | -1,130 | 0.12 | 0.16 | +0.05 | sell |
| WELLS FARGO & COMPANY/MN | 20,952 | 18,513 | -2,439 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 20,381 | 14,668 | -5,713 | 0.01 | 0.02 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 56,897 | 48,173 | -8,724 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 9,395 | 0 | -9,395 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 36,344 | 26,081 | -10,263 | 0.74 | 0.91 | +0.16 | sell |
| TWO SIGMA INVESTMENTS, LP | 11,031 | 0 | -11,031 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 75,644 | 41,307 | -34,337 | 0.07 | 0.06 | -0.01 | sell |
| 5AM Venture Management, LLC | 646,524 | 596,660 | -49,864 | 4.05 | 6.57 | +2.53 | sell |
| ADAR1 Capital Management, LLC | 127,159 | 58,708 | -68,451 | 0.65 | 0.56 | -0.09 | sell |
| VANGUARD GROUP INC | 442,814 | 361,048 | -81,766 | 0.00 | 0.00 | +0.00 | sell |
| Aisling Capital Management LP | 84,148 | 0 | -84,148 | 0.98 | 0.00 | -0.98 | sell |
| Verition Fund Management LLC | 114,778 | 26,171 | -88,607 | 0.02 | 0.01 | -0.02 | sell |
| Ikarian Capital, LLC | 267,145 | 142,328 | -124,817 | 2.51 | 1.88 | -0.64 | sell |
| Prosight Management, LP | 137,614 | 0 | -137,614 | 1.06 | 0.00 | -1.06 | sell |
| BML Capital Management, LLC | 211,752 | 0 | -211,752 | 3.78 | 0.00 | -3.78 | sell |
| Atlas Venture Life Science Advisors, LLC | 378,447 | 78,447 | -300,000 | 1.06 | 0.44 | -0.62 | sell |