| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 100,000 | 903,400 | +803,400 | 0.01 | 0.11 | +0.10 | buy |
| Aberdeen Group plc | 356,176 | 1,141,824 | +785,648 | 0.01 | 0.04 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 0 | 574,600 | +574,600 | 0.00 | 0.25 | +0.25 | buy |
| Vestal Point Capital, LP | 0 | 328,000 | +328,000 | 0.00 | 0.25 | +0.25 | buy |
| Opaleye Management Inc. | 0 | 214,747 | +214,747 | 0.00 | 0.59 | +0.59 | buy |
| BRAIDWELL LP | 736,867 | 927,524 | +190,657 | 0.34 | 0.62 | +0.28 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 151,713 | +151,713 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 65,435 | 199,646 | +134,211 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 120,250 | +120,250 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 13,017 | 111,188 | +98,171 | 0.00 | 0.03 | +0.02 | buy |
| 5AM Venture Management, LLC | 511,660 | 606,660 | +95,000 | 2.94 | 3.98 | +1.04 | buy |
| Point72 Asset Management, L.P. | 421,755 | 492,332 | +70,577 | 0.01 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 63,276 | +63,276 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 238,170 | 300,820 | +62,650 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 165,531 | 209,125 | +43,594 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 42,724 | +42,724 | 0.00 | 0.09 | +0.09 | buy |
| Jump Financial, LLC | 0 | 39,500 | +39,500 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 39,109 | +39,109 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 569,480 | 599,898 | +30,418 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 43,885 | 71,657 | +27,772 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 827,853 | 854,363 | +26,510 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 22,262 | +22,262 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 298,388 | 317,617 | +19,229 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 102,473 | 120,411 | +17,938 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 15,369 | +15,369 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 15,251 | +15,251 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 13,046 | +13,046 | 0.00 | 0.07 | +0.07 | buy |
| Marex Group plc | 0 | 12,501 | +12,501 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 7,299 | 18,187 | +10,888 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 10,075 | +10,075 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 5,071 | 13,462 | +8,391 | 0.02 | 0.08 | +0.05 | buy |
| SIMPLEX TRADING, LLC | 768 | 9,142 | +8,374 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 0 | 7,589 | +7,589 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,410 | +6,410 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 6,300 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 25,076 | 30,918 | +5,842 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 1,500 | 6,500 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 17,976 | 22,443 | +4,467 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 23,894 | 26,594 | +2,700 | 0.28 | 0.37 | +0.09 | buy |
| RAYMOND JAMES FINANCIAL INC | 51,931 | 54,601 | +2,670 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 259,726 | 261,026 | +1,300 | 0.45 | 0.70 | +0.26 | buy |
| FMR LLC | 2,806,781 | 2,807,442 | +661 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 587 | +587 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 208,776 | 209,225 | +449 | 0.07 | 0.09 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,422 | 2,819 | +397 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 373 | +373 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 173 | 541 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 723 | 909 | +186 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,358 | 32,461 | +103 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 384 | 466 | +82 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 62 | +62 | 0.00 | 0.00 | +0.00 | buy |
| OPTIMA CAPITAL LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 8 | 29 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 910 | 929 | +19 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 37,362 | 37,379 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,122 | 1,122 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 164 | 164 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 6,724 | 6,724 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bollard Group LLC | 302,953 | 302,953 | 0 | 0.12 | 0.17 | +0.05 | hold |
| Clarius Group, LLC | 10,130 | 10,130 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Woodline Partners LP | 200,000 | 200,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Vermillion & White Wealth Management Group, LLC | 107 | 107 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 14,304 | 14,304 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knott David M Jr | 74,000 | 74,000 | 0 | 0.49 | 0.71 | +0.23 | hold |
| Global Wealth Strategies & Associates | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,638 | 2,638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caldwell Trust Co | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 37 | 37 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,050 | 1,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 684 | 676 | -8 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Rise Advisors, LLC | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 375 | 345 | -30 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 403 | 367 | -36 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,134 | 5,079 | -55 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 633 | 537 | -96 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 1,158 | 1,033 | -125 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 5,924 | 5,779 | -145 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 26,133 | 25,858 | -275 | 0.00 | 0.00 | +0.00 | sell |
| Federation des caisses Desjardins du Quebec | 1,000 | 500 | -500 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,465 | 752 | -713 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,880 | 6,050 | -830 | 0.01 | 0.01 | +0.00 | sell |
| Aldebaran Capital, LLC | 38,502 | 37,353 | -1,149 | 0.55 | 0.70 | +0.14 | sell |
| RHUMBLINE ADVISERS | 15,993 | 14,196 | -1,797 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 3,966 | 0 | -3,966 | 0.04 | 0.00 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 96,866 | 92,703 | -4,163 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 269,353 | 263,560 | -5,793 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 28,720 | 19,321 | -9,399 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 104,733 | 94,435 | -10,298 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 10,662 | 0 | -10,662 | 0.00 | 0.00 | -0.00 | sell |