| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JW Asset Management, LLC | 3,192,485 | 3,192,485 | 0 | 47.18 | 59.36 | +12.18 | hold |
| RTW INVESTMENTS, LP | 2,494,138 | 2,675,703 | +181,565 | 1.01 | 2.01 | +1.00 | buy |
| BROWN ADVISORY INC | 2,428,792 | 2,318,721 | -110,071 | 0.09 | 0.16 | +0.07 | sell |
| Nantahala Capital Management, LLC | 2,470,154 | 1,964,562 | -505,592 | 6.40 | 9.80 | +3.39 | sell |
| JPMORGAN CHASE & CO | 747,063 | 948,456 | +201,393 | 0.00 | 0.00 | +0.00 | buy |
| Capital Research Global Investors | 0 | 901,532 | +901,532 | 0.00 | 0.01 | +0.01 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 567,000 | 785,020 | +218,020 | 9.24 | 21.64 | +12.40 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 750,909 | 738,020 | -12,889 | 1.13 | 2.14 | +1.02 | sell |
| MORGAN STANLEY | 673,195 | 681,849 | +8,654 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 123,227 | 678,224 | +554,997 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 570,770 | +570,770 | 0.00 | 0.08 | +0.08 | buy |
| Polar Capital Holdings Plc | 226,519 | 546,519 | +320,000 | 0.04 | 0.15 | +0.11 | buy |
| BAMCO INC /NY/ | 334,775 | 429,775 | +95,000 | 0.02 | 0.06 | +0.04 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 420,724 | +420,724 | 0.00 | 0.06 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 353,644 | +353,644 | 0.00 | 0.03 | +0.03 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 389,160 | 351,630 | -37,530 | 0.20 | 0.33 | +0.13 | sell |
| CITIGROUP INC | 0 | 332,880 | +332,880 | 0.00 | 0.02 | +0.02 | buy |
| PURA VIDA INVESTMENTS, LLC | 417,994 | 261,673 | -156,321 | 2.58 | 9.06 | +6.48 | sell |
| Avidity Partners Management LP | 0 | 225,000 | +225,000 | 0.00 | 0.41 | +0.41 | buy |
| Mudita Advisors LLP | 142,400 | 184,222 | +41,822 | 2.56 | 5.58 | +3.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 148,058 | 172,662 | +24,604 | 0.00 | 0.01 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 166,297 | +166,297 | 0.00 | 0.40 | +0.40 | buy |
| Affinity Asset Advisors, LLC | 228,277 | 164,589 | -63,688 | 1.18 | 1.36 | +0.18 | sell |
| Caption Management, LLC | 59,900 | 162,800 | +102,900 | 0.17 | 0.91 | +0.74 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 157,522 | +157,522 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,052 | 141,162 | +138,110 | 0.00 | 0.42 | +0.42 | buy |
| CWM, LLC | 146,071 | 115,181 | -30,890 | 0.02 | 0.03 | +0.01 | sell |
| Redmile Group, LLC | 0 | 114,341 | +114,341 | 0.00 | 0.21 | +0.21 | buy |
| BARCLAYS PLC | 3,331 | 108,797 | +105,466 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 294 | 97,222 | +96,928 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 168,858 | 97,111 | -71,747 | 0.15 | 0.14 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 87,385 | +87,385 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 39,618 | 83,622 | +44,004 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 82,299 | 82,299 | 0 | 0.05 | 0.07 | +0.03 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 82,217 | +82,217 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 69,588 | 77,798 | +8,210 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 99,650 | 76,525 | -23,125 | 0.06 | 0.08 | +0.02 | sell |
| Union Square Park Capital Management, LLC | 0 | 60,000 | +60,000 | 0.00 | 5.76 | +5.76 | buy |
| Parallax Volatility Advisers, L.P. | 18,465 | 58,912 | +40,447 | 0.01 | 0.09 | +0.07 | buy |
| AMERIPRISE FINANCIAL INC | 40,934 | 56,575 | +15,641 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 172,100 | 54,514 | -117,586 | 0.11 | 0.06 | -0.05 | sell |
| STATE STREET CORP | 45,009 | 46,951 | +1,942 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 27,600 | 44,572 | +16,972 | 0.00 | 0.01 | +0.01 | buy |
| NorthRock Partners, LLC | 42,931 | 42,931 | 0 | 0.05 | 0.08 | +0.04 | hold |
| MARSHALL WACE, LLP | 9,993 | 42,243 | +32,250 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 48,445 | 38,445 | -10,000 | 0.04 | 0.06 | +0.02 | sell |
| Swiss National Bank | 33,000 | 37,500 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| STABLEFORD CAPITAL II LLC | 0 | 30,815 | +30,815 | 0.00 | 0.63 | +0.63 | buy |
| BigSur Wealth Management LLC | 34,033 | 28,983 | -5,050 | 0.42 | 0.46 | +0.04 | sell |
| CenterBook Partners LP | 0 | 28,357 | +28,357 | 0.00 | 0.10 | +0.10 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,881 | 27,696 | +3,815 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 26,771 | +26,771 | 0.00 | 0.04 | +0.04 | buy |
| Simplify Asset Management Inc. | 11,863 | 25,493 | +13,630 | 0.05 | 0.12 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 23,702 | 25,220 | +1,518 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 24,850 | +24,850 | 0.00 | 0.30 | +0.30 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 23,271 | +23,271 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 27,730 | 22,232 | -5,498 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 20,661 | 20,154 | -507 | 0.00 | 0.00 | +0.00 | sell |
| Maxi Investments CY Ltd | 0 | 20,000 | +20,000 | 0.00 | 0.27 | +0.27 | buy |
| STEPHENS INC /AR/ | 0 | 17,323 | +17,323 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,929 | 17,096 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 15,219 | 16,617 | +1,398 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 16,190 | 15,625 | -565 | 0.00 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 18,773 | 15,178 | -3,595 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 0 | 14,978 | +14,978 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 14,664 | +14,664 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 58,934 | 13,300 | -45,634 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 0 | 12,995 | +12,995 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 102,259 | 12,806 | -89,453 | 0.04 | 0.01 | -0.03 | sell |
| Cubist Systematic Strategies, LLC | 87,120 | 12,742 | -74,378 | 0.03 | 0.01 | -0.02 | sell |
| Bayesian Capital Management, LP | 0 | 12,400 | +12,400 | 0.00 | 0.06 | +0.06 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 11,678 | +11,678 | 0.00 | 0.34 | +0.34 | buy |
| Ensign Peak Advisors, Inc | 10,740 | 10,224 | -516 | 0.00 | 0.00 | +0.00 | sell |
| LMR Partners LLP | 29,109 | 10,000 | -19,109 | 0.02 | 0.01 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 9,157 | +9,157 | 0.00 | 0.03 | +0.03 | buy |
| Diametric Capital, LP | 7,796 | 8,814 | +1,018 | 0.12 | 0.25 | +0.13 | buy |
| JANUS HENDERSON GROUP PLC | 8,376 | 8,376 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 34,870 | 7,255 | -27,615 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 44,462 | 7,024 | -37,438 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 6,360 | +6,360 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 5,582 | +5,582 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 5,578 | +5,578 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 5,524 | +5,524 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 5,450 | +5,450 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 5,225 | +5,225 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 0 | 5,175 | +5,175 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,591 | 4,591 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS Group AG | 0 | 4,288 | +4,288 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 3,289 | 3,289 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Trading LLC | 0 | 3,264 | +3,264 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Twin Lakes Capital Management, LLC | 2,931 | 2,931 | 0 | 0.05 | 0.10 | +0.05 | hold |
| Aquatic Capital Management LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| MV CAPITAL MANAGEMENT, INC. | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Belvedere Trading LLC | 0 | 1,626 | +1,626 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 784 | 1,604 | +820 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 1,411 | 1,253 | -158 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 910 | +910 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 822 | +822 | 0.00 | 0.00 | +0.00 | buy |