| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JW Asset Management, LLC | 3,192,485 | 3,192,485 | 0 | 59.36 | 59.77 | +0.41 | hold |
| RTW INVESTMENTS, LP | 2,675,703 | 2,675,703 | 0 | 2.01 | 1.88 | -0.13 | hold |
| Nantahala Capital Management, LLC | 1,964,562 | 2,512,850 | +548,288 | 9.80 | 11.47 | +1.67 | buy |
| BROWN ADVISORY INC | 2,318,721 | 2,160,293 | -158,428 | 0.16 | 0.13 | -0.03 | sell |
| FINDELL CAPITAL MANAGEMENT LLC | 785,020 | 1,111,100 | +326,080 | 21.64 | 25.21 | +3.57 | buy |
| Capital Research Global Investors | 901,532 | 1,000,744 | +99,212 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 948,456 | 910,076 | -38,380 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 738,020 | 716,341 | -21,679 | 2.14 | 1.95 | -0.19 | sell |
| MORGAN STANLEY | 681,849 | 693,962 | +12,113 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 546,519 | 546,519 | 0 | 0.15 | 0.15 | +0.00 | hold |
| Avidity Partners Management LP | 225,000 | 531,000 | +306,000 | 0.41 | 1.03 | +0.62 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 420,724 | 481,572 | +60,848 | 0.06 | 0.06 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 97,111 | 432,043 | +334,932 | 0.14 | 0.59 | +0.46 | buy |
| BAMCO INC /NY/ | 429,775 | 430,775 | +1,000 | 0.06 | 0.06 | -0.00 | buy |
| Sofinnova Investments, Inc. | 141,162 | 429,244 | +288,082 | 0.42 | 1.23 | +0.81 | buy |
| First Turn Management, LLC | 0 | 369,980 | +369,980 | 0.00 | 2.73 | +2.73 | buy |
| Mudita Advisors LLP | 184,222 | 298,101 | +113,879 | 5.58 | 6.94 | +1.35 | buy |
| MILLENNIUM MANAGEMENT LLC | 172,662 | 273,605 | +100,943 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 265,942 | +265,942 | 0.00 | 0.03 | +0.03 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 351,630 | 242,385 | -109,245 | 0.33 | 0.21 | -0.12 | sell |
| PURA VIDA INVESTMENTS, LLC | 261,673 | 230,093 | -31,580 | 9.06 | 12.64 | +3.57 | sell |
| Affinity Asset Advisors, LLC | 164,589 | 223,407 | +58,818 | 1.36 | 1.60 | +0.24 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 166,297 | 220,575 | +54,278 | 0.40 | 0.46 | +0.06 | buy |
| Redmile Group, LLC | 114,341 | 213,024 | +98,683 | 0.21 | 0.59 | +0.37 | buy |
| CITADEL ADVISORS LLC | 678,224 | 177,440 | -500,784 | 0.03 | 0.01 | -0.03 | sell |
| Divisadero Street Capital Management, LP | 0 | 128,284 | +128,284 | 0.00 | 0.95 | +0.95 | buy |
| ExodusPoint Capital Management, LP | 0 | 107,952 | +107,952 | 0.00 | 0.05 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 353,644 | 100,000 | -253,644 | 0.03 | 0.01 | -0.03 | sell |
| Union Square Park Capital Management, LLC | 60,000 | 95,000 | +35,000 | 5.76 | 6.63 | +0.87 | buy |
| CWM, LLC | 115,181 | 93,074 | -22,107 | 0.03 | 0.02 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 87,385 | 86,771 | -614 | 0.01 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 77,798 | 79,330 | +1,532 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 157,522 | 76,417 | -81,105 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 22,232 | 60,111 | +37,879 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 56,575 | 57,121 | +546 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 44,572 | 50,227 | +5,655 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 46,951 | 47,970 | +1,019 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 54,514 | 46,622 | -7,892 | 0.06 | 0.04 | -0.02 | sell |
| NorthRock Partners, LLC | 42,931 | 45,276 | +2,345 | 0.08 | 0.08 | -0.01 | buy |
| Lighthouse Investment Partners, LLC | 14,664 | 42,702 | +28,038 | 0.03 | 0.11 | +0.07 | buy |
| STABLEFORD CAPITAL II LLC | 30,815 | 42,102 | +11,287 | 0.63 | 0.79 | +0.16 | buy |
| SEI INVESTMENTS CO | 5,524 | 40,576 | +35,052 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 37,500 | 37,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 82,217 | 34,604 | -47,613 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 83,622 | 34,364 | -49,258 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 10,000 | 32,938 | +22,938 | 0.01 | 0.03 | +0.02 | buy |
| BigSur Wealth Management LLC | 28,983 | 28,982 | -1 | 0.46 | 0.40 | -0.06 | sell |
| CANTOR FITZGERALD, L. P. | 24,850 | 28,876 | +4,026 | 0.30 | 0.26 | -0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,445 | 28,445 | -10,000 | 0.06 | 0.04 | -0.02 | sell |
| CenterBook Partners LP | 28,357 | 27,903 | -454 | 0.10 | 0.08 | -0.02 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 26,093 | +26,093 | 0.00 | 0.10 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 25,220 | 25,396 | +176 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 22,970 | +22,970 | 0.00 | 0.07 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 27,696 | 21,820 | -5,876 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 21,700 | +21,700 | 0.00 | 0.88 | +0.88 | buy |
| Maxi Investments CY Ltd | 20,000 | 20,000 | 0 | 0.27 | 0.20 | -0.07 | hold |
| Qube Research & Technologies Ltd | 7,024 | 19,888 | +12,864 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 20,154 | 19,350 | -804 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 16,617 | 18,712 | +2,095 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,096 | 17,203 | +107 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 570,770 | 15,893 | -554,877 | 0.08 | 0.00 | -0.08 | sell |
| Soleus Capital Management, L.P. | 0 | 15,000 | +15,000 | 0.00 | 0.06 | +0.06 | buy |
| Diametric Capital, LP | 8,814 | 14,427 | +5,613 | 0.25 | 0.36 | +0.11 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 13,049 | +13,049 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 12,995 | 12,995 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Simplify Asset Management Inc. | 25,493 | 12,907 | -12,586 | 0.12 | 0.05 | -0.07 | sell |
| STEPHENS INC /AR/ | 17,323 | 12,497 | -4,826 | 0.01 | 0.01 | -0.01 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 11,678 | 11,925 | +247 | 0.34 | 0.32 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 10,633 | +10,633 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 5,450 | 10,550 | +5,100 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 10,224 | 10,224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SkyView Investment Advisors, LLC | 0 | 9,195 | +9,195 | 0.00 | 0.07 | +0.07 | buy |
| JANUS HENDERSON GROUP PLC | 8,376 | 8,376 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bay Colony Advisory Group, Inc d/b/a Bay Colony Advisors | 0 | 8,199 | +8,199 | 0.00 | 0.06 | +0.06 | buy |
| Engineers Gate Manager LP | 0 | 8,166 | +8,166 | 0.00 | 0.01 | +0.01 | buy |
| CI INVESTMENTS INC. | 3,000 | 8,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 5,582 | 7,782 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 7,696 | +7,696 | 0.00 | 0.06 | +0.06 | buy |
| Verition Fund Management LLC | 0 | 7,654 | +7,654 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 9,157 | 7,358 | -1,799 | 0.03 | 0.03 | -0.00 | sell |
| MARSHALL WACE, LLP | 42,243 | 7,000 | -35,243 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 2,500 | 6,700 | +4,200 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 6,658 | +6,658 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 5,400 | 6,200 | +800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 910 | 6,151 | +5,241 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 5,225 | 5,331 | +106 | 0.00 | 0.00 | -0.00 | buy |
| Concurrent Investment Advisors, LLC | 5,175 | 5,075 | -100 | 0.01 | 0.01 | -0.00 | sell |
| NKCFO LLC | 0 | 5,000 | +5,000 | 0.00 | 0.12 | +0.12 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 97,222 | 4,847 | -92,375 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 4,288 | 3,455 | -833 | 0.00 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 3,289 | 3,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Twin Lakes Capital Management, LLC | 2,931 | 2,931 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,591 | 2,746 | -1,845 | 0.00 | 0.00 | -0.00 | sell |
| MV CAPITAL MANAGEMENT, INC. | 2,000 | 2,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 26,771 | 1,685 | -25,086 | 0.04 | 0.00 | -0.04 | sell |
| DEUTSCHE BANK AG\ | 1,604 | 1,317 | -287 | 0.00 | 0.00 | -0.00 | sell |
| Hood River Capital Management LLC | 0 | 950 | +950 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 682 | 682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| nVerses Capital, LLC | 100 | 400 | +300 | 0.01 | 0.01 | -0.00 | buy |