| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JW Asset Management, LLC | 3,192,485 | 3,192,485 | 0 | 59.77 | 62.37 | +2.60 | hold |
| RTW INVESTMENTS, LP | 2,675,703 | 2,645,703 | -30,000 | 1.88 | 1.66 | -0.23 | sell |
| Nantahala Capital Management, LLC | 2,512,850 | 2,359,141 | -153,709 | 11.47 | 8.59 | -2.88 | sell |
| BROWN ADVISORY INC | 2,160,293 | 1,900,312 | -259,981 | 0.13 | 0.10 | -0.03 | sell |
| Capital Research Global Investors | 1,000,744 | 1,478,041 | +477,297 | 0.01 | 0.01 | +0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 1,111,100 | 1,028,100 | -83,000 | 25.21 | 23.16 | -2.05 | sell |
| JPMORGAN CHASE & CO | 910,076 | 903,415 | -6,661 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 716,341 | 793,300 | +76,959 | 1.95 | 1.86 | -0.09 | buy |
| MORGAN STANLEY | 693,962 | 700,757 | +6,795 | 0.00 | 0.00 | -0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 481,572 | 563,937 | +82,365 | 0.06 | 0.06 | +0.00 | buy |
| Polar Capital Holdings Plc | 546,519 | 546,519 | 0 | 0.15 | 0.11 | -0.03 | hold |
| BAMCO INC /NY/ | 430,775 | 489,386 | +58,611 | 0.06 | 0.06 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 265,942 | 480,166 | +214,224 | 0.03 | 0.05 | +0.02 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 220,575 | 471,109 | +250,534 | 0.46 | 0.92 | +0.46 | buy |
| First Turn Management, LLC | 369,980 | 357,003 | -12,977 | 2.73 | 2.45 | -0.29 | sell |
| Mudita Advisors LLP | 298,101 | 354,801 | +56,700 | 6.94 | 8.40 | +1.47 | buy |
| Divisadero Street Capital Management, LP | 128,284 | 341,139 | +212,855 | 0.95 | 1.90 | +0.95 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 432,043 | 311,129 | -120,914 | 0.59 | 0.40 | -0.19 | sell |
| Affinity Asset Advisors, LLC | 223,407 | 290,447 | +67,040 | 1.60 | 1.95 | +0.35 | buy |
| Redmile Group, LLC | 213,024 | 261,803 | +48,779 | 0.59 | 0.67 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 273,605 | 261,478 | -12,127 | 0.01 | 0.01 | -0.00 | sell |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 242,385 | 248,435 | +6,050 | 0.21 | 0.20 | -0.01 | buy |
| PURA VIDA INVESTMENTS, LLC | 230,093 | 191,939 | -38,154 | 12.64 | 13.65 | +1.01 | sell |
| Sofinnova Investments, Inc. | 429,244 | 181,476 | -247,768 | 1.23 | 0.65 | -0.58 | sell |
| Avidity Partners Management LP | 531,000 | 169,000 | -362,000 | 1.03 | 0.37 | -0.65 | sell |
| Altium Capital Management LLC | 0 | 131,000 | +131,000 | 0.00 | 1.69 | +1.69 | buy |
| CITADEL ADVISORS LLC | 177,440 | 120,933 | -56,507 | 0.01 | 0.01 | -0.00 | sell |
| Union Square Park Capital Management, LLC | 95,000 | 108,808 | +13,808 | 6.63 | 6.36 | -0.27 | buy |
| GOLDMAN SACHS GROUP INC | 34,364 | 108,790 | +74,426 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 57,121 | 97,893 | +40,772 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 86,771 | 86,771 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CWM, LLC | 93,074 | 80,301 | -12,773 | 0.02 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 79,330 | 78,742 | -588 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 75,000 | +75,000 | 0.00 | 2.05 | +2.05 | buy |
| MARSHALL WACE, LLP | 7,000 | 63,173 | +56,173 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 76,417 | 61,362 | -15,055 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 15,000 | 59,400 | +44,400 | 0.06 | 0.21 | +0.15 | buy |
| Portolan Capital Management, LLC | 0 | 56,533 | +56,533 | 0.00 | 0.18 | +0.18 | buy |
| Point72 Asset Management, L.P. | 15,893 | 49,400 | +33,507 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 47,970 | 48,057 | +87 | 0.00 | 0.00 | -0.00 | buy |
| NorthRock Partners, LLC | 45,276 | 45,276 | 0 | 0.08 | 0.06 | -0.01 | hold |
| D. E. Shaw & Co., Inc. | 0 | 44,648 | +44,648 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,820 | 41,351 | +19,531 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 50,227 | 40,790 | -9,437 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 60,111 | 40,477 | -19,634 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 40,000 | +40,000 | 0.00 | 0.14 | +0.14 | buy |
| Magnetar Financial LLC | 46,622 | 37,637 | -8,985 | 0.04 | 0.04 | -0.01 | sell |
| Swiss National Bank | 37,500 | 37,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 0 | 35,729 | +35,729 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 34,604 | 35,236 | +632 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 40,576 | 34,740 | -5,836 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 14,427 | 33,950 | +19,523 | 0.36 | 0.73 | +0.37 | buy |
| BigSur Wealth Management LLC | 28,982 | 31,982 | +3,000 | 0.40 | 0.38 | -0.02 | buy |
| FEDERATED HERMES, INC. | 0 | 31,767 | +31,767 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 323 | 31,471 | +31,148 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,633 | 29,277 | +18,644 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 26,607 | +26,607 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 28,445 | 26,358 | -2,087 | 0.04 | 0.03 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 25,396 | 25,356 | -40 | 0.00 | 0.00 | -0.00 | sell |
| STABLEFORD CAPITAL II LLC | 42,102 | 25,144 | -16,958 | 0.79 | 0.40 | -0.39 | sell |
| Cubist Systematic Strategies, LLC | 0 | 22,740 | +22,740 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 21,700 | 21,700 | 0 | 0.88 | 0.63 | -0.24 | hold |
| Simplify Asset Management Inc. | 12,907 | 21,639 | +8,732 | 0.05 | 0.06 | +0.01 | buy |
| NKCFO LLC | 5,000 | 20,000 | +15,000 | 0.12 | 0.41 | +0.29 | buy |
| TWINBEECH CAPITAL LP | 0 | 19,573 | +19,573 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 18,712 | 18,712 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 19,350 | 18,300 | -1,050 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,203 | 16,815 | -388 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 7,358 | 12,364 | +5,006 | 0.03 | 0.04 | +0.01 | buy |
| SkyView Investment Advisors, LLC | 9,195 | 12,000 | +2,805 | 0.07 | 0.09 | +0.01 | buy |
| SIT INVESTMENT ASSOCIATES INC | 10,550 | 10,550 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HighTower Advisors, LLC | 7,782 | 10,311 | +2,529 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 10,224 | 10,224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CI INVESTMENTS INC. | 8,000 | 10,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 32,938 | 10,000 | -22,938 | 0.03 | 0.01 | -0.02 | sell |
| Maven Securities LTD | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| Verition Fund Management LLC | 7,654 | 9,400 | +1,746 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 22,970 | 9,345 | -13,625 | 0.07 | 0.03 | -0.04 | sell |
| JANUS HENDERSON GROUP PLC | 8,376 | 8,376 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE TRADING, LLC | 0 | 7,648 | +7,648 | 0.00 | 0.01 | +0.01 | buy |
| Black Swift Group, LLC | 0 | 7,200 | +7,200 | 0.00 | 0.07 | +0.07 | buy |
| Handelsbanken Fonder AB | 6,200 | 6,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 3,455 | 5,972 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 5,555 | +5,555 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 5,331 | 5,547 | +216 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 5,384 | +5,384 | 0.00 | 0.02 | +0.02 | buy |
| GTS SECURITIES LLC | 0 | 5,290 | +5,290 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,151 | 5,257 | -894 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 6,700 | 4,000 | -2,700 | 0.01 | 0.00 | -0.01 | sell |
| BESSEMER GROUP INC | 3,289 | 3,063 | -226 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 2,933 | +2,933 | 0.00 | 0.02 | +0.02 | buy |
| Twin Lakes Capital Management, LLC | 2,931 | 2,931 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,746 | 2,746 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 2,047 | +2,047 | 0.00 | 0.00 | +0.00 | buy |
| MV CAPITAL MANAGEMENT, INC. | 2,000 | 2,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 14 | 1,986 | +1,972 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,875 | +1,875 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 950 | 1,760 | +810 | 0.00 | 0.00 | +0.00 | buy |