| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 5,072,730 | 5,072,730 | 0 | 0.31 | 0.37 | +0.06 | hold |
| 5AM Venture Management, LLC | 4,056,379 | 4,056,379 | 0 | 13.11 | 14.21 | +1.10 | hold |
| BlackRock, Inc. | 2,147,260 | 2,358,793 | +211,533 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,088,392 | 2,287,500 | +199,108 | 0.71 | 0.83 | +0.12 | buy |
| Merck & Co., Inc. | 1,739,768 | 1,739,768 | 0 | 6.47 | 6.28 | -0.19 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,044,758 | 1,034,782 | -9,976 | 0.00 | 0.00 | +0.00 | sell |
| StepStone Group LP | 761,277 | 761,277 | 0 | 4.19 | 4.63 | +0.44 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 639,947 | 667,347 | +27,400 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 508,789 | 533,798 | +25,009 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 327,423 | 526,043 | +198,620 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 497,695 | 519,356 | +21,661 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 362,786 | 333,914 | -28,872 | 0.01 | 0.02 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 310,833 | 333,169 | +22,336 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 273,378 | 324,471 | +51,093 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 226,301 | 234,992 | +8,691 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 142,110 | 215,977 | +73,867 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 292,770 | 215,018 | -77,752 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,269 | 214,751 | -6,518 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 205,173 | 212,780 | +7,607 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 51,689 | 211,689 | +160,000 | 0.11 | 0.42 | +0.31 | buy |
| Longaeva Partners L.P. | 0 | 204,978 | +204,978 | 0.00 | 0.12 | +0.12 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 252,635 | 202,084 | -50,551 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 180,969 | 181,148 | +179 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 260,251 | 176,126 | -84,125 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 56,416 | 175,648 | +119,232 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 159,332 | +159,332 | 0.00 | 0.13 | +0.13 | buy |
| XTX Topco Ltd | 117,668 | 129,562 | +11,894 | 0.03 | 0.03 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 247,147 | 120,845 | -126,302 | 0.03 | 0.02 | -0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 105,000 | 0 | 0.02 | 0.05 | +0.03 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 89,358 | +89,358 | 0.00 | 0.80 | +0.80 | buy |
| Qube Research & Technologies Ltd | 176,018 | 87,453 | -88,565 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 121,280 | 82,733 | -38,547 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 26,254 | 79,493 | +53,239 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 66,878 | 79,047 | +12,169 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,282 | 77,971 | +2,689 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 79,375 | 76,427 | -2,948 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 67,717 | 71,018 | +3,301 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,545 | 70,656 | +14,111 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 84,893 | 70,280 | -14,613 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 20,657 | 53,764 | +33,107 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 37,788 | 53,588 | +15,800 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 49,082 | 49,082 | 0 | 0.45 | 0.51 | +0.06 | hold |
| CANTOR FITZGERALD, L. P. | 57,000 | 47,000 | -10,000 | 0.02 | 0.02 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 49,302 | 44,602 | -4,700 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 41,033 | 41,926 | +893 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 37,053 | 41,763 | +4,710 | 0.01 | 0.01 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 43,268 | 41,531 | -1,737 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 65,979 | 39,212 | -26,767 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 20,833 | 38,137 | +17,304 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37,502 | 37,502 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 85,662 | 37,213 | -48,449 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 36,223 | 35,938 | -285 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 30,500 | +30,500 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 67,147 | 28,676 | -38,471 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 47,967 | 26,349 | -21,618 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | 25,000 | -15,000 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 20,821 | 24,679 | +3,858 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,320 | 24,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 22,082 | 22,230 | +148 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 21,548 | +21,548 | 0.00 | 0.04 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 17,495 | 19,465 | +1,970 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 18,175 | +18,175 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 17,802 | 17,802 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 25,600 | 17,700 | -7,900 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 20,318 | 17,538 | -2,780 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 16,822 | 16,943 | +121 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 25,302 | 16,474 | -8,828 | 0.06 | 0.03 | -0.03 | sell |
| JPMORGAN CHASE & CO | 70,761 | 14,847 | -55,914 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,248 | 13,577 | +329 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 37,430 | 12,067 | -25,363 | 0.00 | 0.00 | -0.00 | sell |
| Inscription Capital, LLC | 11,835 | 11,835 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Russell Investments Group, Ltd. | 11,571 | 11,633 | +62 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 11,102 | +11,102 | 0.00 | 0.00 | +0.00 | buy |
| IHT Wealth Management, LLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 32,163 | 11,011 | -21,152 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 9,471 | 9,471 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,877 | 8,877 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 6,228 | 6,794 | +566 | 0.00 | 0.01 | +0.00 | buy |
| CWM, LLC | 2,114 | 6,788 | +4,674 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,124 | 4,853 | +729 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 4,046 | 4,046 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 2,557 | 2,557 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,417 | 2,417 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,857 | 1,997 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,937 | 1,670 | -267 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,753 | 1,540 | -213 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 432 | 1,417 | +985 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,640 | 943 | -697 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 918 | 919 | +1 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 751 | 852 | +101 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 95 | 480 | +385 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 22 | 435 | +413 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 376 | 420 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 309 | +309 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 346 | 258 | -88 | 0.00 | 0.00 | +0.00 | sell |
| Private Wealth Management Group, LLC | 212 | 212 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 167 | 208 | +41 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 186 | 186 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 161 | 161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |