| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 5,072,730 | 5,072,730 | 0 | 0.37 | 0.19 | -0.18 | hold |
| 5AM Venture Management, LLC | 4,056,379 | 4,056,379 | 0 | 14.21 | 10.37 | -3.84 | hold |
| BlackRock, Inc. | 2,358,793 | 2,583,333 | +224,540 | 0.00 | 0.00 | -0.00 | buy |
| Merck & Co., Inc. | 0 | 1,739,768 | +1,739,768 | 0.00 | 2.43 | +2.43 | buy |
| MPM BioImpact LLC | 0 | 1,253,053 | +1,253,053 | 0.00 | 0.56 | +0.56 | buy |
| TCG Crossover Management, LLC | 2,287,500 | 1,060,230 | -1,227,270 | 0.83 | 0.19 | -0.64 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,034,782 | 954,419 | -80,363 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 519,356 | 763,959 | +244,603 | 0.00 | 0.00 | -0.00 | buy |
| StepStone Group LP | 761,277 | 761,277 | 0 | 4.63 | 0.26 | -4.37 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 667,347 | 717,430 | +50,083 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 79,493 | 699,537 | +620,044 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 533,798 | 596,677 | +62,879 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 526,043 | 542,316 | +16,273 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 14,847 | 496,457 | +481,610 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 333,169 | 400,862 | +67,693 | 0.01 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 215,018 | 394,323 | +179,305 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 324,471 | 376,136 | +51,665 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 234,992 | 309,942 | +74,950 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 333,914 | 303,459 | -30,455 | 0.02 | 0.01 | -0.01 | sell |
| Nantahala Capital Management, LLC | 159,332 | 300,575 | +141,243 | 0.13 | 0.13 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 197,136 | +197,136 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214,751 | 197,136 | -17,615 | 0.00 | 0.00 | -0.00 | sell |
| Longaeva Partners L.P. | 204,978 | 195,237 | -9,741 | 0.12 | 0.04 | -0.08 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 202,084 | 191,000 | -11,084 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 71,018 | 188,839 | +117,821 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 211,689 | 178,606 | -33,083 | 0.42 | 0.15 | -0.27 | sell |
| GOLDMAN SACHS GROUP INC | 212,780 | 177,343 | -35,437 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 215,977 | 145,600 | -70,377 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 82,733 | 140,143 | +57,410 | 0.01 | 0.01 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 105,000 | 0 | 0.05 | 0.02 | -0.03 | hold |
| XTX Topco Ltd | 129,562 | 95,337 | -34,225 | 0.03 | 0.01 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 181,148 | 95,044 | -86,104 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 19,465 | 93,538 | +74,073 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 88,005 | +88,005 | 0.00 | 0.04 | +0.04 | buy |
| ROYCE & ASSOCIATES LP | 120,845 | 82,902 | -37,943 | 0.02 | 0.00 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 77,971 | 79,701 | +1,730 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 76,427 | 79,070 | +2,643 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 70,656 | 72,520 | +1,864 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 70,280 | 70,395 | +115 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 87,453 | 60,872 | -26,581 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 47,000 | 60,000 | +13,000 | 0.02 | 0.01 | -0.01 | buy |
| Nuveen, LLC | 175,648 | 56,777 | -118,871 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 54,113 | +54,113 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 53,588 | 53,588 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 12,067 | 52,767 | +40,700 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 49,082 | 49,082 | 0 | 0.51 | 0.27 | -0.24 | hold |
| TWO SIGMA INVESTMENTS, LP | 44,602 | 46,402 | +1,800 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 41,926 | 44,344 | +2,418 | 0.00 | 0.00 | -0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 41,531 | 38,511 | -3,020 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 41,763 | 38,263 | -3,500 | 0.01 | 0.01 | -0.01 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37,502 | 37,502 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 35,938 | 36,743 | +805 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 38,137 | 36,470 | -1,667 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 34,687 | +34,687 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 26,349 | 33,969 | +7,620 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 33,457 | +33,457 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 18,175 | 33,351 | +15,176 | 0.02 | 0.02 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 79,047 | 32,397 | -46,650 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 24,320 | 31,640 | +7,320 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 29,679 | +29,679 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 28,676 | 28,600 | -76 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 28,500 | +28,500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,794 | 27,778 | +20,984 | 0.01 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 24,679 | 26,556 | +1,877 | 0.00 | 0.00 | -0.00 | buy |
| Voleon Capital Management LP | 0 | 25,324 | +25,324 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 11,011 | 24,902 | +13,891 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 24,072 | +24,072 | 0.00 | 0.00 | +0.00 | buy |
| Inscription Capital, LLC | 11,835 | 23,941 | +12,106 | 0.02 | 0.02 | -0.00 | buy |
| Russell Investments Group, Ltd. | 11,633 | 23,450 | +11,817 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 21,707 | +21,707 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 20,653 | +20,653 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,802 | 17,655 | -147 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 30,500 | 15,500 | -15,000 | 0.02 | 0.01 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 15,493 | +15,493 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,853 | 14,790 | +9,937 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,577 | 13,551 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 0 | 13,511 | +13,511 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 17,538 | 13,257 | -4,281 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 12,769 | +12,769 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,471 | 9,471 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,877 | 8,877 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 0 | 5,014 | +5,014 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 919 | 4,478 | +3,559 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 4,046 | 4,221 | +175 | 0.01 | 0.00 | -0.00 | buy |
| STRS OHIO | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 161 | 2,972 | +2,811 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,670 | 2,916 | +1,246 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,417 | 2,688 | +1,271 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 2,557 | 2,557 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,417 | 2,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 16,943 | 2,169 | -14,774 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 1,968 | +1,968 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,997 | 1,736 | -261 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 0 | 1,233 | +1,233 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 852 | 812 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 309 | 647 | +338 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 420 | 642 | +222 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 943 | 593 | -350 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 480 | 525 | +45 | 0.00 | 0.00 | -0.00 | buy |