| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,865,819 | 4,865,819 | 0 | 0.32 | 0.20 | -0.11 | hold |
| MPM ASSET MANAGEMENT LLC | 4,381,062 | 4,381,062 | 0 | 67.92 | 57.09 | -10.83 | hold |
| 5AM Venture Management, LLC | 4,308,379 | 4,256,379 | -52,000 | 11.13 | 9.04 | -2.09 | sell |
| BlackRock, Inc. | 2,022,150 | 2,044,044 | +21,894 | 0.00 | 0.00 | -0.00 | buy |
| Merck & Co., Inc. | 1,739,768 | 1,739,768 | 0 | 5.42 | 4.43 | -1.00 | hold |
| VANGUARD GROUP INC | 1,604,860 | 1,604,225 | -635 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,060,716 | 954,419 | -106,297 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 170,322 | 836,609 | +666,287 | 0.00 | 0.00 | +0.00 | buy |
| StepStone Group LP | 761,277 | 761,277 | 0 | 10.14 | 2.08 | -8.07 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 631,554 | 645,119 | +13,565 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 379,500 | 594,300 | +214,800 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 584,955 | 584,955 | 0 | 0.45 | 0.17 | -0.28 | hold |
| STATE STREET CORP | 495,862 | 498,615 | +2,753 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 423,985 | 394,279 | -29,706 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,567,478 | 360,526 | -2,206,952 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 0 | 346,756 | +346,756 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 223,251 | 345,507 | +122,256 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 100,357 | 335,741 | +235,384 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 220,736 | 315,810 | +95,074 | 0.01 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 45,806 | 297,943 | +252,137 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 133,730 | 287,873 | +154,143 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 300,321 | 253,607 | -46,714 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 51,158 | 247,516 | +196,358 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 84,150 | 222,336 | +138,186 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 203,693 | 185,259 | -18,434 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,045 | 148,212 | +145,167 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 16,034 | 133,878 | +117,844 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 129,812 | +129,812 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 126,448 | +126,448 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 10,577 | 122,865 | +112,288 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 122,676 | +122,676 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 98,028 | 105,806 | +7,778 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 105,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Walleye Capital LLC | 17,409 | 96,681 | +79,272 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 93,194 | +93,194 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 93,079 | +93,079 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,094 | 75,394 | +300 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 71,548 | +71,548 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 44,946 | 69,926 | +24,980 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 67,334 | +67,334 | 0.00 | 0.08 | +0.08 | buy |
| BARCLAYS PLC | 58,082 | 60,630 | +2,548 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 18,622 | 58,229 | +39,607 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,824 | 56,932 | +1,108 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 56,416 | 56,416 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 55,960 | +55,960 | 0.00 | 0.03 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 44,632 | 52,079 | +7,447 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 51,500 | +51,500 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 49,082 | 49,082 | 0 | 0.52 | 0.48 | -0.04 | hold |
| ROYAL BANK OF CANADA | 0 | 42,139 | +42,139 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 41,029 | +41,029 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 39,095 | 39,428 | +333 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 28,755 | 38,849 | +10,094 | 0.23 | 0.55 | +0.33 | buy |
| TD ASSET MANAGEMENT INC | 47,788 | 37,788 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 39,463 | 37,053 | -2,410 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 496,129 | 31,946 | -464,183 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 30,812 | +30,812 | 0.00 | 0.01 | +0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 10,148 | 29,486 | +19,338 | 0.01 | 0.02 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 29,161 | +29,161 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 22,393 | 29,075 | +6,682 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,002 | 28,202 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 25,754 | +25,754 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 22,700 | 24,320 | +1,620 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,100 | 21,616 | +3,516 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 15,535 | 21,008 | +5,473 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 20,639 | +20,639 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 18,573 | +18,573 | 0.00 | 0.05 | +0.05 | buy |
| Quadrature Capital Ltd | 0 | 17,894 | +17,894 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 16,092 | 15,935 | -157 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 11,979 | 14,495 | +2,516 | 0.03 | 0.02 | -0.00 | buy |
| NewEdge Advisors, LLC | 0 | 14,167 | +14,167 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,620 | 13,991 | -21,629 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 17,702 | 13,843 | -3,859 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,388 | 13,108 | -2,280 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 11,954 | +11,954 | 0.00 | 0.00 | +0.00 | buy |
| Inscription Capital, LLC | 0 | 11,835 | +11,835 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 11,570 | +11,570 | 0.00 | 0.03 | +0.03 | buy |
| IHT Wealth Management, LLC | 10,700 | 11,100 | +400 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,924 | 9,471 | +4,547 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,877 | 8,877 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 5,101 | 8,808 | +3,707 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,895 | 7,358 | +3,463 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,329 | 7,160 | -9,169 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,623 | 6,667 | -956 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 39,625 | 6,475 | -33,150 | 0.03 | 0.00 | -0.02 | sell |
| Versant Capital Management, Inc | 1,464 | 4,019 | +2,555 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 45,000 | 3,800 | -41,200 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,557 | 2,557 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,417 | 2,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 13,406 | 2,049 | -11,357 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 96,686 | 2,018 | -94,668 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 697 | 1,941 | +1,244 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,789 | 1,790 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,466 | 1,471 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 1,358 | +1,358 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 465 | 1,279 | +814 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 377 | 1,193 | +816 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 852 | 852 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 958 | 807 | -151 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 746 | 432 | -314 | 0.00 | 0.00 | -0.00 | sell |