| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Advantage Alpha Capital Partners LP | 0 | 105,137 | +105,137 | 0.00 | 0.30 | +0.30 | buy |
| AMERICAN CENTURY COMPANIES INC | 138,798 | 238,645 | +99,847 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 66,953 | 115,060 | +48,107 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,020,317 | 1,065,166 | +44,849 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 5,932 | 31,730 | +25,798 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 403,253 | 427,832 | +24,579 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 23,967 | +23,967 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,700 | 24,100 | +21,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 438,581 | 459,381 | +20,800 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 10,485 | 28,576 | +18,091 | 0.08 | 0.14 | +0.05 | buy |
| Invesco Ltd. | 0 | 17,296 | +17,296 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 13,206 | +13,206 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,000,037 | 3,009,673 | +9,636 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 13,311 | 22,476 | +9,165 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 5,932 | +5,932 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 12,804 | 18,064 | +5,260 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,003 | 5,780 | +4,777 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 23,344 | 27,430 | +4,086 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31 | 3,110 | +3,079 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 2,668 | +2,668 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,174 | 11,714 | +2,540 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,045,652 | 1,047,780 | +2,128 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 26,449 | 28,492 | +2,043 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,327 | 6,627 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 908 | +908 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,767 | 1,767 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 119,254 | 119,254 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 4,425,784 | 4,425,784 | 0 | 37.45 | 32.82 | -4.64 | hold |
| BAKER BROS. ADVISORS LP | 4,865,819 | 4,865,819 | 0 | 0.44 | 0.84 | +0.39 | hold |
| NATIXIS | 31,186 | 31,186 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 105,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| StepStone Group LP | 761,277 | 761,277 | 0 | 2.68 | 2.07 | -0.61 | hold |
| MetLife Investment Management, LLC | 11,694 | 11,694 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 10,874 | 10,874 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 49,082 | 49,082 | 0 | 0.63 | 0.46 | -0.17 | hold |
| 5AM Venture Management, LLC | 4,408,379 | 4,408,379 | 0 | 20.04 | 17.65 | -2.40 | hold |
| TCG Crossover Management, LLC | 584,955 | 584,955 | 0 | 1.36 | 0.98 | -0.38 | hold |
| Allspring Global Investments Holdings, LLC | 2,798 | 2,798 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,212 | 1,212 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 11,062 | 11,062 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 10,679 | 10,636 | -43 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,925 | 8,877 | -48 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,081 | 1,866 | -215 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 10,038 | 9,808 | -230 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 1,284,000 | 1,283,735 | -265 | 0.97 | 0.69 | -0.27 | sell |
| JPMORGAN CHASE & CO | 14,581 | 14,154 | -427 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,149 | 55,675 | -474 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,007 | 14,210 | -797 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 25,200 | 23,000 | -2,200 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 155,224 | 151,358 | -3,866 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 205,061 | 200,688 | -4,373 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,023 | 0 | -10,023 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 13,977 | 0 | -13,977 | 0.04 | 0.00 | -0.04 | sell |
| FMR LLC | 582,116 | 535,523 | -46,593 | 0.00 | 0.00 | -0.00 | sell |
| 72 Investment Holdings, LLC | 509,023 | 172,600 | -336,423 | 53.88 | 11.57 | -42.32 | sell |