| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,865,819 | 5,072,730 | +206,911 | 0.20 | 0.31 | +0.10 | buy |
| 5AM Venture Management, LLC | 4,256,379 | 4,056,379 | -200,000 | 9.04 | 13.11 | +4.07 | sell |
| BlackRock, Inc. | 2,044,044 | 2,147,260 | +103,216 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 584,955 | 2,088,392 | +1,503,437 | 0.17 | 0.71 | +0.54 | buy |
| Merck & Co., Inc. | 1,739,768 | 1,739,768 | 0 | 4.43 | 6.47 | +2.05 | hold |
| VANGUARD GROUP INC | 1,604,225 | 1,632,460 | +28,235 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 954,419 | 1,044,758 | +90,339 | 0.00 | 0.00 | +0.00 | buy |
| StepStone Group LP | 761,277 | 761,277 | 0 | 2.08 | 4.19 | +2.11 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 645,119 | 639,947 | -5,172 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 498,615 | 508,789 | +10,174 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 836,609 | 497,695 | -338,914 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 315,810 | 362,786 | +46,976 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 360,526 | 327,423 | -33,103 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 297,943 | 310,833 | +12,890 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 335,741 | 292,770 | -42,971 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 394,279 | 273,378 | -120,901 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 346,756 | 260,251 | -86,505 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 594,300 | 252,635 | -341,665 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 345,507 | 247,147 | -98,360 | 0.02 | 0.03 | +0.01 | sell |
| NORTHERN TRUST CORP | 253,607 | 226,301 | -27,306 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,259 | 221,269 | +36,010 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 222,336 | 205,173 | -17,163 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 148,212 | 180,969 | +32,757 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 287,873 | 176,018 | -111,855 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 0 | 142,110 | +142,110 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 129,812 | 128,611 | -1,201 | 0.01 | 0.02 | +0.01 | sell |
| Trexquant Investment LP | 122,865 | 121,280 | -1,585 | 0.01 | 0.01 | +0.00 | sell |
| XTX Topco Ltd | 93,079 | 117,668 | +24,589 | 0.03 | 0.03 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 110,942 | +110,942 | 0.00 | 0.24 | +0.24 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 105,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| JANE STREET GROUP, LLC | 247,516 | 85,662 | -161,854 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 69,926 | 84,893 | +14,967 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 105,806 | 79,375 | -26,431 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 75,394 | 75,282 | -112 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 133,878 | 70,761 | -63,117 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 58,229 | 67,717 | +9,488 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 60,630 | 67,147 | +6,517 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 71,548 | 66,878 | -4,670 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 126,448 | 65,979 | -60,469 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 67,334 | 57,000 | -10,334 | 0.08 | 0.02 | -0.06 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,932 | 56,545 | -387 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 56,416 | 56,416 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lynx1 Capital Management LP | 0 | 51,689 | +51,689 | 0.00 | 0.11 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 93,194 | 49,302 | -43,892 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 49,082 | 49,082 | 0 | 0.48 | 0.45 | -0.03 | hold |
| Brevan Howard Capital Management LP | 0 | 47,967 | +47,967 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 52,079 | 45,952 | -6,127 | 0.00 | 0.00 | +0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 41,029 | 43,268 | +2,239 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 29,075 | 41,033 | +11,958 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | 40,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 37,788 | 37,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 28,202 | 37,502 | +9,300 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 37,430 | +37,430 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 37,053 | 37,053 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 39,428 | 36,223 | -3,205 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 21,616 | 32,163 | +10,547 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,991 | 26,254 | +12,263 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 25,600 | +25,600 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 25,302 | +25,302 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,320 | 24,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 0 | 22,082 | +22,082 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 21,871 | +21,871 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 20,639 | 20,833 | +194 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 21,008 | 20,821 | -187 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 0 | 20,657 | +20,657 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 17,894 | 20,318 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 7,160 | 17,802 | +10,642 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 15,935 | 17,495 | +1,560 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 31,946 | 16,822 | -15,124 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 6,475 | 15,629 | +9,154 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 14,017 | +14,017 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 96,681 | 13,534 | -83,147 | 0.00 | 0.00 | -0.00 | sell |
| Magnetar Financial LLC | 0 | 13,373 | +13,373 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,108 | 13,248 | +140 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,843 | 11,929 | -1,914 | 0.00 | 0.00 | +0.00 | sell |
| Inscription Capital, LLC | 11,835 | 11,835 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Russell Investments Group, Ltd. | 8,808 | 11,571 | +2,763 | 0.00 | 0.00 | +0.00 | buy |
| IHT Wealth Management, LLC | 11,100 | 11,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AXQ CAPITAL, LP | 11,570 | 10,650 | -920 | 0.03 | 0.02 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 9,471 | 9,471 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,877 | 8,877 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 6,667 | 6,228 | -439 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 2,049 | 4,124 | +2,075 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 4,019 | 4,046 | +27 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 2,557 | 2,557 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,417 | 2,417 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 1,193 | 2,114 | +921 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,358 | 1,937 | -5,421 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,471 | 1,857 | +386 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,790 | 1,753 | -37 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 1,941 | 1,640 | -301 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 1,279 | 918 | -361 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 852 | 894 | +42 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 807 | 751 | -56 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 432 | 432 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 389 | 376 | -13 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 346 | 346 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Wealth Management Group, LLC | 212 | 212 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 0 | 186 | +186 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |