| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 358,618 | 425,167 | +66,549 | 1.16 | 1.03 | -0.13 | buy |
| University of Wisconsin Foundation | 25,215 | 34,730 | +9,515 | 7.21 | 9.21 | +1.99 | buy |
| Nicholas Investment Partners, LP | 3,948 | 13,113 | +9,165 | 0.09 | 0.25 | +0.16 | buy |
| Alyeska Investment Group, L.P. | 72,178 | 80,846 | +8,668 | 0.07 | 0.07 | +0.00 | buy |
| HighVista Strategies LLC | 26,323 | 30,210 | +3,887 | 2.34 | 2.31 | -0.04 | buy |
| PFM Health Sciences, LP | 35,438 | 38,575 | +3,137 | 1.04 | 1.11 | +0.07 | buy |
| Legato Capital Management LLC | 670 | 3,171 | +2,501 | 0.02 | 0.09 | +0.07 | buy |
| J. Goldman & Co LP | 15,664 | 16,186 | +522 | 0.15 | 0.14 | -0.01 | buy |
| Bellevue Group AG | 1,757 | 1,847 | +90 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 38,640 | 38,684 | +44 | 0.21 | 0.17 | -0.03 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 46 | 66 | +20 | 0.01 | 0.01 | +0.00 | buy |
| J.Safra Asset Management Corp | 54 | 61 | +7 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 16 | 7 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Gallagher Fiduciary Advisors, LLC | 990 | 957 | -33 | 0.01 | 0.01 | -0.00 | sell |
| Abel Hall, LLC | 1,392 | 1,019 | -373 | 0.10 | 0.06 | -0.04 | sell |
| China Universal Asset Management Co., Ltd. | 4,942 | 4,437 | -505 | 0.12 | 0.09 | -0.03 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 84,901 | 82,796 | -2,105 | 19.30 | 19.32 | +0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 21,688 | 19,066 | -2,622 | 1.26 | 1.15 | -0.11 | sell |
| Candriam S.C.A. | 63,628 | 60,856 | -2,772 | 0.11 | 0.09 | -0.01 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 10,043 | 7,252 | -2,791 | 0.02 | 0.02 | -0.00 | sell |
| SummitTX Capital, L.P. | 36,838 | 19,779 | -17,059 | 0.37 | 0.17 | -0.20 | sell |
| Sofinnova Investments, Inc. | 63,680 | 6,440 | -57,240 | 0.78 | 0.11 | -0.67 | sell |
| Vivo Capital, LLC | 338,895 | 271,116 | -67,779 | 9.08 | 8.29 | -0.79 | sell |
| ArrowMark Colorado Holdings LLC | 117,851 | 46,030 | -71,821 | 1.01 | 0.64 | -0.37 | sell |
| Cormorant Asset Management, LP | 885,500 | 640,000 | -245,500 | 14.33 | 10.98 | -3.35 | sell |
| Orbis Allan Gray Ltd | 2,472,480 | 1,529,788 | -942,692 | 3.36 | 1.76 | -1.60 | sell |