| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 828,380 | +828,380 | 0.00 | 0.64 | +0.64 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 821,589 | +821,589 | 0.00 | 0.88 | +0.88 | buy |
| Cormorant Asset Management, LP | 633,345 | 1,310,000 | +676,655 | 0.68 | 3.52 | +2.85 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 738,666 | 1,393,028 | +654,362 | 0.03 | 0.16 | +0.13 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 535,999 | +535,999 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 460,512 | +460,512 | 0.00 | 0.52 | +0.52 | buy |
| FMR LLC | 115 | 442,621 | +442,506 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 370,938 | 744,069 | +373,131 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 353,626 | 706,126 | +352,500 | 0.54 | 2.05 | +1.51 | buy |
| 5AM Venture Management, LLC | 0 | 340,000 | +340,000 | 0.00 | 4.65 | +4.65 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 310,059 | +310,059 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 266,496 | +266,496 | 0.00 | 0.16 | +0.16 | buy |
| Point72 Asset Management, L.P. | 692,252 | 954,140 | +261,888 | 0.05 | 0.17 | +0.12 | buy |
| Octagon Capital Advisors LP | 0 | 260,000 | +260,000 | 0.00 | 1.93 | +1.93 | buy |
| Laurion Capital Management LP | 0 | 225,000 | +225,000 | 0.00 | 0.38 | +0.38 | buy |
| Vestal Point Capital, LP | 0 | 210,000 | +210,000 | 0.00 | 1.06 | +1.06 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 177,139 | +177,139 | 0.00 | 1.75 | +1.75 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,346 | 176,952 | +154,606 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 150,000 | +150,000 | 0.00 | 0.96 | +0.96 | buy |
| FRANKLIN RESOURCES INC | 0 | 145,295 | +145,295 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 131,533 | +131,533 | 0.00 | 0.10 | +0.10 | buy |
| Qube Research & Technologies Ltd | 25,104 | 132,942 | +107,838 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 100,136 | +100,136 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 98,635 | +98,635 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 95,181 | +95,181 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 94,332 | +94,332 | 0.00 | 0.15 | +0.15 | buy |
| Hudson Bay Capital Management LP | 0 | 93,000 | +93,000 | 0.00 | 0.05 | +0.05 | buy |
| Ally Bridge Group (NY) LLC | 70,424 | 159,486 | +89,062 | 0.93 | 5.41 | +4.48 | buy |
| Altium Capital Management LLC | 0 | 78,100 | +78,100 | 0.00 | 2.13 | +2.13 | buy |
| MARSHALL WACE, LLP | 48,842 | 121,024 | +72,182 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 0 | 71,253 | +71,253 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,284 | 106,159 | +57,875 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 51,372 | +51,372 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 47,041 | +47,041 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 92,958 | 134,717 | +41,759 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 40,119 | +40,119 | 0.00 | 1.62 | +1.62 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 39,565 | +39,565 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 37,268 | +37,268 | 0.00 | 0.20 | +0.20 | buy |
| JANE STREET GROUP, LLC | 10,576 | 47,066 | +36,490 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 27,667 | +27,667 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 27,263 | +27,263 | 0.00 | 0.02 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 0 | 26,893 | +26,893 | 0.00 | 0.44 | +0.44 | buy |
| Alyeska Investment Group, L.P. | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 20,000 | +20,000 | 0.00 | 0.14 | +0.14 | buy |
| Maven Securities LTD | 0 | 20,000 | +20,000 | 0.00 | 0.07 | +0.07 | buy |
| Ovata Capital Management Ltd | 0 | 20,000 | +20,000 | 0.00 | 0.64 | +0.64 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 19,865 | +19,865 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 173,868 | 192,304 | +18,436 | 0.01 | 0.04 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 16,180 | +16,180 | 0.00 | 0.09 | +0.09 | buy |
| HRT FINANCIAL LP | 0 | 14,764 | +14,764 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 9,426 | 23,372 | +13,946 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 30,708 | 44,508 | +13,800 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 160 | 13,522 | +13,362 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,311 | +13,311 | 0.00 | 0.00 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 0 | 12,917 | +12,917 | 0.00 | 0.37 | +0.37 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,278 | 34,729 | +12,451 | 0.02 | 0.06 | +0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,776 | +11,776 | 0.00 | 0.05 | +0.05 | buy |
| Marathon Trading Investment Management LLC | 0 | 9,000 | +9,000 | 0.00 | 0.22 | +0.22 | buy |
| NORTHERN TRUST CORP | 19,364 | 27,279 | +7,915 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 7,612 | +7,612 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,245 | 16,445 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,750 | +6,750 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 6,689 | +6,689 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 6,406 | +6,406 | 0.00 | 0.00 | +0.00 | buy |
| Windmill Hill Asset Management Ltd | 0 | 5,268 | +5,268 | 0.00 | 0.12 | +0.12 | buy |
| NORGES BANK | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 345,666 | 350,666 | +5,000 | 5.45 | 11.57 | +6.12 | buy |
| Aberdeen Group plc | 0 | 4,999 | +4,999 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 30,037 | 34,867 | +4,830 | 0.12 | 0.27 | +0.15 | buy |
| Trexquant Investment LP | 0 | 4,343 | +4,343 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 4,261 | +4,261 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 4,244 | +4,244 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 4,028 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 0 | 3,846 | +3,846 | 0.00 | 0.05 | +0.05 | buy |
| CHASE INVESTMENT COUNSEL CORP | 0 | 3,768 | +3,768 | 0.00 | 0.09 | +0.09 | buy |
| Polymer Capital Management (HK) LTD | 0 | 3,726 | +3,726 | 0.00 | 0.06 | +0.06 | buy |
| Jump Financial, LLC | 0 | 3,449 | +3,449 | 0.00 | 0.01 | +0.01 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 346,665 | 350,000 | +3,335 | 1.47 | 2.83 | +1.36 | buy |
| Man Group plc | 13,139 | 15,921 | +2,782 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 2,465 | +2,465 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,392 | 3,355 | +1,963 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,848 | +1,848 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 13,710 | 15,040 | +1,330 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 966 | +966 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 654 | +654 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 21,152 | 21,152 | 0 | 0.01 | 0.03 | +0.02 | hold |
| RHUMBLINE ADVISERS | 152 | 152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FSA Wealth Management LLC | 21 | 21 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 6.52 | 6.00 | -0.53 | hold |
| DEUTSCHE BANK AG\ | 152 | 152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 46,710 | 42,803 | -3,907 | 0.04 | 0.07 | +0.04 | sell |
| J. Goldman & Co LP | 18,000 | 12,336 | -5,664 | 0.02 | 0.03 | +0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 11,531 | 5,627 | -5,904 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 23,524 | 15,118 | -8,406 | 0.00 | 0.00 | +0.00 | sell |
| DLD Asset Management, LP | 10,000 | 0 | -10,000 | 0.04 | 0.00 | -0.04 | sell |
| 683 Capital Management, LLC | 11,481 | 0 | -11,481 | 0.03 | 0.00 | -0.03 | sell |