| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 605,010 | 1,742,758 | +1,137,748 | 0.08 | 0.12 | +0.04 | buy |
| Soleus Capital Management, L.P. | 243,540 | 1,139,740 | +896,200 | 1.42 | 3.38 | +1.97 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 619,931 | +619,931 | 0.00 | 0.47 | +0.47 | buy |
| JANUS HENDERSON GROUP PLC | 929,523 | 1,506,436 | +576,913 | 0.04 | 0.03 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 5,504 | 460,707 | +455,203 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 403,003 | +403,003 | 0.00 | 0.04 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 164,912 | 481,598 | +316,686 | 0.10 | 0.18 | +0.07 | buy |
| Woodline Partners LP | 9,948 | 175,727 | +165,779 | 0.01 | 0.04 | +0.04 | buy |
| Sofinnova Investments, Inc. | 0 | 157,640 | +157,640 | 0.00 | 0.45 | +0.45 | buy |
| Ikarian Capital, LLC | 0 | 145,502 | +145,502 | 0.00 | 1.80 | +1.80 | buy |
| Sio Capital Management, LLC | 0 | 112,500 | +112,500 | 0.00 | 1.29 | +1.29 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 72,516 | 166,074 | +93,558 | 1.25 | 1.31 | +0.07 | buy |
| Aberdeen Group plc | 4,999 | 87,903 | +82,904 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 120,267 | 192,909 | +72,642 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 18,615 | 87,081 | +68,466 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 65,265 | +65,265 | 0.00 | 0.06 | +0.06 | buy |
| Cormorant Asset Management, LP | 1,693,219 | 1,745,000 | +51,781 | 7.16 | 5.00 | -2.15 | buy |
| Ally Bridge Group (NY) LLC | 44,982 | 95,582 | +50,600 | 2.97 | 3.26 | +0.29 | buy |
| MORGAN STANLEY | 1,163,526 | 1,213,669 | +50,143 | 0.01 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 91,583 | 140,660 | +49,077 | 1.30 | 1.31 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 46,626 | +46,626 | 0.00 | 0.06 | +0.06 | buy |
| Tri Locum Partners LP | 37,269 | 83,659 | +46,390 | 0.59 | 1.63 | +1.03 | buy |
| Walleye Capital LLC | 89,613 | 131,756 | +42,143 | 0.07 | 0.06 | -0.01 | buy |
| PFM Health Sciences, LP | 119,509 | 160,866 | +41,357 | 0.70 | 0.47 | -0.23 | buy |
| ExodusPoint Capital Management, LP | 0 | 39,975 | +39,975 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 45,427 | 78,588 | +33,161 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 10,951 | 39,286 | +28,335 | 0.31 | 0.57 | +0.26 | buy |
| First Turn Management, LLC | 45,536 | 71,775 | +26,239 | 0.63 | 0.55 | -0.08 | buy |
| VANGUARD GROUP INC | 1,063,639 | 1,087,020 | +23,381 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Asset Management Inc | 366,756 | 388,759 | +22,003 | 0.09 | 0.05 | -0.04 | buy |
| ALGERT GLOBAL LLC | 0 | 21,490 | +21,490 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 0 | 19,779 | +19,779 | 0.00 | 0.09 | +0.09 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 67,500 | 87,141 | +19,641 | 5.23 | 3.83 | -1.40 | buy |
| B Group, Inc. | 0 | 19,000 | +19,000 | 0.00 | 0.63 | +0.63 | buy |
| Caption Management, LLC | 0 | 18,280 | +18,280 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 406,711 | 418,016 | +11,305 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 10,927 | +10,927 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 10,043 | +10,043 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 0 | 7,774 | +7,774 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 5,682 | 12,977 | +7,295 | 0.03 | 0.04 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 6,250 | +6,250 | 0.00 | 0.02 | +0.02 | buy |
| Shay Capital LLC | 0 | 5,500 | +5,500 | 0.00 | 0.06 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,142 | 7,451 | +5,309 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,682 | 14,611 | +3,929 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 3,850 | 7,606 | +3,756 | 0.01 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,726 | 16,346 | +3,620 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 3,004 | +3,004 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 2,722 | 5,449 | +2,727 | 0.01 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 6,338 | 8,798 | +2,460 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,316 | +2,316 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 3,227 | 5,408 | +2,181 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 9,693 | 11,479 | +1,786 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 22,769 | 24,294 | +1,525 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 26,100 | 27,100 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,135 | 11,708 | +573 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,503 | 26,793 | +290 | 0.05 | 0.02 | -0.03 | buy |
| NISA INVESTMENT ADVISORS, LLC | 71 | 334 | +263 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,952 | 4,044 | +92 | 0.03 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 391 | 477 | +86 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 621 | 675 | +54 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 95 | 148 | +53 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 65 | 106 | +41 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Hemington Wealth Management | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 3 | 20 | +17 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 60 | 65 | +5 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 597 | 599 | +2 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,689 | 1,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUSSMAN STRATEGIC ADVISORS, INC. | 10,500 | 10,500 | 0 | 0.24 | 0.10 | -0.14 | hold |
| PRINCIPAL SECURITIES, INC. | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 331,533 | 331,533 | 0 | 0.27 | 0.14 | -0.13 | hold |
| Sterling Capital Management LLC | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 62 | 62 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 989,985 | 989,985 | 0 | 5.23 | 3.19 | -2.04 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 2,800 | 2,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 170,000 | 170,000 | 0 | 3.12 | 2.43 | -0.69 | hold |
| FSA Wealth Management LLC | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 10.33 | 7.02 | -3.32 | hold |
| Covestor Ltd | 1 | 1 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,789 | 3,789 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 217 | 217 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,999 | 39,999 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,040 | 6,040 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 2 | 0 | -2 | 0.00 | 0.00 | 0.00 | sell |
| Parallel Advisors, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |