| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 605,010 | 1,742,758 | +1,137,748 | 0.08 | 0.12 | +0.04 | buy |
| Soleus Capital Management, L.P. | 243,540 | 1,139,740 | +896,200 | 1.42 | 3.38 | +1.97 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 164,912 | 481,598 | +316,686 | 0.10 | 0.18 | +0.07 | buy |
| Woodline Partners LP | 9,948 | 175,727 | +165,779 | 0.01 | 0.04 | +0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 72,516 | 166,074 | +93,558 | 1.25 | 1.31 | +0.07 | buy |
| Aberdeen Group plc | 4,999 | 87,903 | +82,904 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 1,693,219 | 1,745,000 | +51,781 | 7.16 | 4.97 | -2.19 | buy |
| Ally Bridge Group (NY) LLC | 44,982 | 95,582 | +50,600 | 2.97 | 3.26 | +0.29 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 91,583 | 140,660 | +49,077 | 1.27 | 1.23 | -0.05 | buy |
| Tri Locum Partners LP | 37,269 | 83,659 | +46,390 | 0.59 | 1.63 | +1.03 | buy |
| PFM Health Sciences, LP | 119,509 | 160,866 | +41,357 | 0.57 | 0.44 | -0.13 | buy |
| HighVista Strategies LLC | 10,951 | 39,286 | +28,335 | 0.31 | 0.57 | +0.26 | buy |
| First Turn Management, LLC | 45,536 | 71,775 | +26,239 | 0.63 | 0.55 | -0.08 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 67,500 | 87,141 | +19,641 | 5.23 | 3.83 | -1.40 | buy |
| China Universal Asset Management Co., Ltd. | 3,952 | 4,044 | +92 | 0.03 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 391 | 477 | +86 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 15,066 | 14,938 | -128 | 0.01 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 6,559 | 6,108 | -451 | 0.02 | 0.01 | -0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 30,677 | 30,221 | -456 | 0.44 | 0.24 | -0.20 | sell |
| PCG Wealth Advisors, LLC | 17,282 | 16,413 | -869 | 0.49 | 0.22 | -0.27 | sell |
| Candriam S.C.A. | 117,970 | 63,671 | -54,299 | 0.05 | 0.02 | -0.04 | sell |
| Alyeska Investment Group, L.P. | 226,788 | 150,000 | -76,788 | 0.07 | 0.02 | -0.04 | sell |
| Velan Capital Investment Management LP | 300,000 | 185,000 | -115,000 | 19.92 | 7.21 | -12.72 | sell |
| Capital Research Global Investors | 993,569 | 853,746 | -139,823 | 0.02 | 0.01 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 1,329,735 | 980,894 | -348,841 | 2.82 | 1.31 | -1.51 | sell |